Deltasone: profile and news

Wegener Granulomatosis Feb 10, 2006
Most individuals with Wegener granulomatosis receive steroids such as prednisone (Deltasone) and cyclophosphamide (Cytoxan) together. ... - About - News & Issues,

Autoimmune Inner Ear Disease Sep 21, 2005
...if treatment is started early. Corticosteroid medications such as prednisone (Deltasone) are often effective. The medicine can be ... - rarediseases.about.com

Autoimmune Inner Ear Disease May 18, 2005
...if treatment is started early. Corticosteroid medications such as prednisone (Deltasone) are often effective. The medicine can be ... - rarediseases.about.com

Autoimmune Inner Ear Disease Mar 11, 2005
...if treatment is started early. Corticosteroid medications such as prednisone (Deltasone) are often effective. The medicine can be ... - rarediseases.about.com

Try safer shelving: coroner Feb 13, 2005
The two drugs could have been stored next to each other on the pharmacy's shelves - the prednisone drug under Deltasone, one of its commercial brand names, and ... - Montreal Gazette,

Other information

Indication
For the treatment of primary or secondary adrenocortical insufficiency. Also used in the treatment of several other conditions, including rheumatic disorders, collagen diseases, and dermatological diseases.

Pharmacology
Prednisone, the most commonly-prescribed corticosteroid, is used to treat allograft rejection, asthma, systemic lupus erythematosus, and many other inflammatory states. Prednisone has very little mineralocorticoid activity.

Mechanism Of Action
Prednisone is first metabolized in the liver to its active form, prednisolone. Prednisolone crosses cell membranes and binds with high affinity to specific cytoplasmic receptors. The result includes inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

Drug Category
Antineoplastic Agents; Glucocorticoids; Anti-inflammatory Agents; Adrenergic Agents; ATC:A07EA03; ATC:H02AB07; ATC:H02AB15

Brand Names/Synonyms
&Laquo;Delta&Raquo; E.; &Laquo;Delta&Raquo;-Cortelan; &Laquo;Delta&Raquo;-Cortisone; &Laquo;Delta&Raquo;-Cortone; &Laquo;Delta&Raquo;-Dome; &Laquo;Delta&Raquo;-E; .Delta. E; .Delta.-Cortelan; .Delta.-Cortisone; .Delta.-Cortone; .Delta.-E; .Delta.Sone; Adasone; Ancortone; Apo-Prednisone; Betapar; Bicortone; CCRIS 2646; Cartancyl; Colisone; Cortan; Cortancyl; Cortidelt; Cotone; DRG-0227; Dacorten; Dacortin; Decortancyl; Decortin; Decortisyl; Dehydrocortisone; Dekortin; Delcortin; Dellacort; Dellacort A; Delta Cortelan; Delta E; Delta E.; Delta-Cortelan; Delta-Cortisone; Delta-Dome; Deltacortene; Deltacortisone; Deltacortone; Deltasone; Deltison; Deltisona; Deltisone; Deltra; Di-Adreson; Diadreson; Econosone; Encorton; Encortone; Enkorton; Fernisone; Fiasone; HSDB 3168; Hostacortin; In-Sone; Incocortyl; Juvason; Liquid Pred; Lisacort; Me-Korti; Metacortandracin; Meticorten; Nisona; Nizon; Novoprednisone; Nurison; Orasone; Origen Prednisone; PRD; Panafcort; Panasol; Paracort; Parmenison; Pehacort; Precort; Predeltin; Prednicen-M; Prednicorm; Prednicort; Prednicot; Prednidib; Prednilonga; Prednison; Prednisona [Inn-Spanish]; Prednisone; Prednisone Intensol; Prednisone [Ban:Inn]; Prednisonum [Inn-Latin]; Prednitone; Prednizon; Prednovister; Presone; Pronison; Rectodelt; Reserpine; Reserpine Base; Reserpine Puriss; Retrocortine; Servisone; Sk-Prednisone; Sone; Sterapred; Supercortil; U 6020; Ultracorten; Ultracortene; Winpred; Wojtab; Zenadrid; Zenadrid [Veterinary]

Dosage Forms
Tablets, Ointments, creams, oral liquids

Absorption
readily absorbed from the gastro-intestinal tract

Interactions
Interactions for Prednisone:

The pharmacokinetic interactions listed below are potentially clinically important. Drugs that induce hepatic enzymes such as phenobarbital, phenytoin and rifampin may increase the clearance of corticosteroids and may require increases in corticosteroid dose to achieve the desired response. Drugs such as troleandomycin and ketoconazole may inhibit the metabolism of corticosteroids and thus decrease their clearance. Therefore, the dose of corticosteroid should be titrated to avoid steroid toxicity. Corticosteroids may increase the clearance of chronic high dose aspirin. This could lead to decreased salicylate serum levels or increase the risk of salicylate toxicity when corticosteroid is withdrawn. Aspirin should be used cautiously in conjunction with corticosteroids in patients suffering from hypoprothrombinemia. The effect of corticosteroids on oral anticoagulants is variable. There are reports of enhanced as well as diminished effects of anticoagulants when given concurrently with corticosteroids. Therefore, coagulation indices should be monitored to maintain the desired anticoagulant effect.

Chemical IUPAC Name
17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,10,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,11-dione

Chemical Formula
C21H26O5

Half Life
2 to 3 hours

Drug Type
Approved Drug

# Accession No
APRD00340

CAS Registry Number
53-03-2