Darvon: profile and news






Group asks FDA to ban Darvon  Feb 28, 2006
In a letter to the Food and Drug Administration, Public Citizen said the drug propoxyphene, sold by Xanodyne Pharmaceuticals under the brand Darvon, had been ... - Houston Chronicle,

Group Blames Darvon for Thousands of Deaths, Seeks Ban  Mar 1, 2006
Propoxyphene, sold as Darvon or Darvocet, is converted into a metabolite that is highly toxic to the heart and lasts longer in the body than the original ... - Daily News Central,

Public Citizen Petitions FDA to Ban Darvon  Feb 28, 2006
Public Citizen today petitioned the US Food and Drug Administration (FDA) to immediately begin to phase out Darvon products, saying the widely prescribed pain ... - Consumer Affairs

Group asks FDA to phase out Darvon  Feb 28, 2006
28 (UPI) -- Public Citizen petitioned federal regulators Tuesday to take the painkiller sold as Darvon and Darvocet off the market in the United States. ... - United Press International

'Take Darvon and generic versions off US market', FDA petitioned  Mar 1, 2006
Consumer group Public Citizen yesterday petitioned the US Food and Drug Administration to withdraw the leading painkiller Darvon and its generic versions from ... - Earthtimes.org

Public Citizen Demands FDA to Ban Darvon Products  Feb 28, 2006
...petitioned the US Food and Drug Administration (FDA) to immediately begin to phase out the widely prescribed pain reliever propoxyphene (Darvon, Darvocet and ... - Playfuls.com,

Ban Darvon and Related Painkillers: Public Citizen  Mar 1, 2006
...deaths of at least 2,110 people in the United States between 1981 and 1999, the watchdog group Public Citizen has called for a ban on Darvon, Darvocet and ... - HealthCentral.com

Group urges Darvon, others be phased out  Mar 1, 2006
WASHINGTON -- Darvon, Darvocet, and related painkillers should eventually be banned, a group said yesterday in a government petition that cited the accidental ... - Boston Globe,

Health briefs  Mar 5, 2006
The consumer group Public Citizen is urging the federal Food and Drug Administration to ban the prescription pain reliever commonly sold as Darvon or Darvocet. ... - Chicago Sun-Times,

Consumer Watchdog Group, Public Citizen, Petitions FDA to Ban All ...  Mar 1, 2006
Drug and Cosmetic Act 21, USC Section 355(e)(3), and 21 CFR 10.30 to immediately begin the phased removal from the market of propoxyphene (Darvon) and all ... - Newsinferno.com,

Ban Sought On Some Painkillers  Feb 28, 2006
...(AP) Darvon, Darvocet and related painkillers ... of Wilmington, North Carolina. That company sold Darvon and Darvocet last year to Xanodyne Pharmaceuticals Inc. ... - CBS News

Group seeks federal ban on Darvocet  Feb 28, 2006
WASHINGTON -- Darvon, Darvocet and related painkillers should be phased out and eventually banned, a watchdog group said Tuesday in a government petition that ... - Seattle Post Intelligencer

UPDATE 1-US group petitions FDA to ban pain drug  Feb 28, 2006
WASHINGTON, Feb 28 (Reuters) - The long-time leading prescription painkiller Darvon and its generic versions have been linked to thousands of deaths and should ... - Reuters

Arthritis Blog Archives  Mar 1, 2006
Yet a group known as Public Citizen is petitioning the Food and Drug Administration (FDA) to ban the drugs more commonly known as Darvon, Darvocet, and Wygesic ... - About - News & Issues,

Pain drug too deadly, group says  Feb 28, 2006
...over two decades, a consumer group called Tuesday for the Food and Drug Administration to ban the prescribed pain reliever commonly sold as Darvon or Darvocet. ... - USA Today

Group Seeks Ban on Some Painkillers  Feb 28, 2006
WASHINGTON, Feb. 28 (AP) — Darvon, Darvocet and related painkillers should be phased out and eventually banned, a watchdog group said Tuesday. ... - New York Times,

Darvocet, Others Should Be Off Market, Group Says  Feb 28, 2006
The director of the Public Citizen's Health Research Group said the main ingredient in drugs like Darvon and Darvocet, propoxyphene, is a relatively weak ... - Champlain Channel.com,

Watchdog group seeks federal ban on Darvocet and related ...  Feb 28, 2006
The director of the Public Citizen's Health Research Group says the main ingredient in drugs like Darvon and Darvocet, propoxyphene (proh-PAHKS'-uh-feen), is a ... - WLBT-TV,

Group Says Some Painkillers Should Be Banned  Feb 28, 2006
WASHINGTON (AP) -- The director of the Public Citizen's Health Research Group says the main ingredient in drugs like Darvon and Darvocet, propoxyphene, is a ... - WCSH-TV,

Group Seeks Federal Ban on Darvocet  Feb 28, 2006
WASHINGTON - Darvon, Darvocet and related painkillers should be phased out and eventually banned, a watchdog group said Tuesday in a government petition that ... - Brocktown News,

Group calls for ban of popular drug  Mar 1, 2006
...heart-related deaths. The group says Darvon, made by Xanodyne Pharmaceuticals, has risks which far outweigh its benefits. But the ... - WVLT,

Popular painkiller linked to 2000 deaths  Mar 1, 2006
The group says the widely prescribed pain reliever propoxyphene (Darvon, Darvocet and generic versions), should be phased out because it has been associated ... - News-Medical.net,

PAINKILLERS KILL PEOPLE, TOO: CRITICS  Mar 1, 2006
March 1, 2006 -- Darvon, Darvocet and related painkillers were associated with the deaths of at least 2,110 people from 1981 to 1999, critics said yesterday in ... - New York Post,

Group Seeks Federal Ban on Darvocet  Feb 28, 2006
...(AP) Darvon, Darvocet and related painkillers should be ... of Wilmington, NC That company sold Darvon and Darvocet last year to Xanodyne Pharmaceuticals Inc. ... - CBS News

Darvocet, Others Should Be Off Market, Group Says  Feb 28, 2006
WASHINGTON -- Darvon, Darvocet and related painkillers were associated with the deaths of at least 2,110 people between 1981 and 1999, critics said Tuesday in ... - Channel Oklahoma.com,

Group Seeks Federal Ban on Darvocet  Feb 28, 2006
WASHINGTON Feb 28, 2006 (AP)— Darvon, Darvocet and related painkillers should be phased out and eventually banned, a watchdog group said Tuesday in a ... - ABC News

Police calls  Feb 15, 2006
27-year-old Jamie Lyn Haley of Eyota, Minn., on suspicion of possessing a pipe with methamphetamine residue and possession of two pills — Darvon and Skelaxin ... - Winona Daily News,

Cato Daily Dispatch for March 1, 2006  Mar 1, 2006
...growth.". "Darvon, Darvocet and related painkillers should be phased out and eventually banned, a watchdog group said Tuesday. At ... - Cato Institute,

Heroin may be new menace, but its source is not  Jan 28, 2006
A related group of synthetic opiates includes meperidine (known as Demerol), propoxyphene (known as Darvon), and pentazocine (known as Talwin). ... - New Philadelphia Times Reporter,

Avitar Enters Rapidly Expanding Oral Fluid-Based Laboratory Drug ...  Nov 29, 2005
R)), Diazepam (Valium(R)), Lorazepam (Avitvan(R)), Temazepam(Restoril(R)), Oxazepam (Serax(R)),Nordiazepam (Tranxene(R)) Propoxyphene: (Darvon(R)) * ORALscreen ... - PR Newswire (press release),

Appeals court upholds rulings in Lowe's walkway collapse suits  Sep 20, 2005
The defense argued Drew Hepler was never prescribed some of the drugs found in his system, including key ingredients in the pain medications Darvocet and Darvon ... - USA Today

Doctor faces lawsuit over patient death  Sep 25, 2005
During visits, Alexanderian prescribed Valium, Vicodin, Darvocet, Darvon, Ampicillin, Motrin, Buspar and Soma Tabs with only a few examinations, the suit says. ... - Wilkes Barre Times-Leader,

e-PrescriptionDrugAddiction.com Provides an Overview of ...  Aug 24, 2005
Opioids are usually prescribed for pain relief. Some well-known opioids are codeine, morphine, and pills such as OxyContin, Vicodin, and Darvon. ... - Pressbox.co.uk (press release),

Lunch with Griffin brings back memories  Aug 23, 2005
All the while, I was l making my starts, sometimes on Cortisone, sometimes on Darvon and always on Capsulin — an ointment as hot as pine sap in a forest fire ... - Houston Chronicle,

Vandlingwomanis caught,sentenced  Aug 12, 2005
According to court records, Ms. Snyder was calling in fake prescriptions for pain relievers such as Darvon and Propoxyphene HCL and filling them at the ... - Scranton Times,


Other information


Indication
For pain relief

Pharmacology
Propoxyphene, a synthetic opiate agonist, is structurally similar to methadone. The analgesic effect of propoxyphene is due to the d-isomer, dextropropoxyphene. It binds to the opiate receptors and leads to a decrease of the perception of pain stimuli.

Mechanism Of Action
Propoxyphene acts as a weak agonist at OP1, OP2, and OP3 opiate receptors within the central nervous system (CNS). Propoxyphene primarily affects OP3 receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as Propoxyphene also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.

Drug Category
Narcotics; Antitussives; Analgesics; ATC:N02AC04; ATC:N02AC54; ATC:N02AC74

Brand Names/Synonyms
Algafan; Antalvic; D-Propoxyphene; Darvocet; Darvon; Darvon-N; Deprancol; Depromic; Dextropropoxyphene; Dextropropoxyphene-M; Dextroproxifeno; Dolene; Dolocap; Doloxen; Doloxene; Erantin; Femadol; Harmar; Kesso-Gesic; Propacet; Prophene 65; Propoxychel; Propoxyphene; Propoxyphene Hcl; Propoxyphene Hcl 65; Proxagesic; SK 65

Dosage Forms
Tablets

Absorption
Not Available

Interactions
Interactions for Propoxyphene:

The CNS-depressant effect of propoxyphene is additive with that of other CNS depressants, including alcohol.

As is the case with many medicinal agents, propoxyphene may slow the metabolism of a concomitantly administered drug. Should this occur, the higher serum concentrations of that drug may result in increased pharmacologic or adverse effects of that drug. Such occurrences have been reported when propoxyphene was administered to patients on antidepressants, anticonvulsants, or warfarin-like drugs. Sever neurologic signs, including coma, have occurred with concurrent use of carbamazepine.



Chemical IUPAC Name
(4-dimethylamino-3-methyl-1,2-diphenyl-butan-2-yl) propanoate

Chemical Formula
C22H29NO2

Half Life
6-12 hours

Drug Type
Approved Drug

# Accession No
APRD00548

CAS Registry Number
469-62-5

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