Darvocet: profile and news

Aventis recalls 30 batches of Enoxaparin syringes Feb 10, 2006
Aventis Pharma today announced that Sanofi-Aventis has recalled 30 batches of the anticoagulant enoxaparin (Lovenox, Clexane). According ... - Business Standard,

Sanofi-Aventis recalls enoxaparin syringes Feb 10, 2006
Sanofi-aventis is voluntarily recalling 30 batches of anticoagulant enoxaparin from countries across the world, including India, because of suspected '' over ... - Webindia123,

Aventis Pharma - Sanofi-Aventis Voluntarily Recalls 30 Batches of ... Feb 10, 2006
BSE that Sanofi-aventis has announced that as a precautionary measure it is voluntarily recalling 30 batches of the anticoagulant enoxaparin (Lovenox®, Clexane ... - PharmaLive.com (press release),

New Oral Anticoagulants Show Promise Feb 14, 2006
Now, pooled data from two phase 2 clinical trials have revealed that BAY 59-7939 has similar efficacy and safety to subcutaneous enoxaparin (a low-molecular ... - Journal of American Medical Association (subscription),

Prophylaxis Against Deep-Vein Thrombosis Following Trauma: A ... Feb 22, 2006
The patients in Group A received enoxaparin (30 mg, administered subcutaneously twice a day) starting twenty-four to forty-eight hours after blunt trauma. ... - Journal of Bone and Joint Surgery

Momenta Pharmaceuticals to Present at SG Cowen's 26th Annual ... Mar 3, 2006
The Company's most advanced product candidate is M-Enoxaparin, a technology-enabled generic version of Lovenox(R). Based on its understanding of complex sugars ... - PharmaLive.com (press release),

Momenta Pharmaceuticals Reports Financial Results for the Fourth ... Feb 14, 2006
..."Our development activities were highlighted by the submission of the marketing application for M-Enoxaparin to the FDA in August, as well as by significant ... - MSN Money

Patients warned of clotting drug risk Feb 10, 2006
...announced a product recall after it emerged that some syringes may contain an over-concentration of the active medicinal substance, enoxaparin, which is ... - Irish Examiner,

Momenta Pharmaceuticals to Present at SG Cowen's 26th Annual ... Mar 2, 2006
...products. The Company's most advanced product candidate is M-Enoxaparin, a technology-enabled generic version of Lovenox®. Based ... - Yahoo! News (press release)

Momenta boosts revenue but reports $22M loss in 2005 Feb 14, 2006
The company says its "most advanced product," M-Enoxaparin, a generic version of the drug Lovenox, used as a treatment for acute coronary disease and deeo vein ... - Boston Business Journal,

Sanofi-Aventis recalls 30 lots of Lovenox syringes on overdose ... Feb 10, 2006
PARIS (AFX) - Sanofi-Aventis said it recalled 30 lots of syringes pre-filled with enoxaparin anti-thrombosis treatment and sold under the Lovenox and Clexane ... - Forbes

The lowdown on Omega 3 fatty acids Feb 21, 2006
Such drugs include aspirin, NSAIDs (eg, ibuprofen, naproxen), clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), and warfarin (Coumadin). ... - Contra Costa Times,

Obesity drug rimonabant knocked back at FDA Feb 20, 2006
...when it is facing the threat of generic competition to its two biggest-selling products, the antithrombotic drugs Plavix (clopidogrel) and Lovenox (enoxaparin ... - Pharma Times (subscription),

Sanofi expects Acomplia launch in 06; profits up Feb 24, 2006
The company is also facing the threat of generic competition to its two top-selling drugs, Plavix (clopidogrel) and Lovenox (enoxaparin), while other big ... - Pharma Times (subscription),

Arixtra Administered the Morning After Orthopedic Surgery ... Feb 3, 2006
1989 May. 2. Shaieb MD, Watson BN, Atkinson RE: Bleeding complications with enoxaparin for deep venous thrombosis prophylaxis. J Arthroplasty 14:432, 1999. ... - DG News

Blood clotting drug recalled by IMB Feb 10, 2006
The IMB has recalled the batch due to 'the potential for an over concentration of up to 50% of the active medicinal substance, enoxaparin, in a number of ... - Irish Health,

Arixtra halves blood clot risk, study shows Feb 14, 2006
This could help Arixtra gain some ground on its rival, Sanofi-Aventis' Lovenox (enoxaparin), which is currently market leader with sales of 572 million euros ... - Pharma Times (subscription),

ARIXTRA Administered the Morning After Orthopedic Surgery ... Feb 3, 2006
Clin Orthop Relat Res. 2. Shaieb MD, Watson BN, Atkinson RE: Bleeding complications with. enoxaparin for deep venous thrombosis prophylaxis. J Arthroplasty. ... - PharmaLive.com (press release),

Head-to-Head Trials Published in the Third Quarter of 2005 ... Feb 2, 2006
States in outpatients. Sanofi-Aventis's Lovenox (enoxaparin) will likely face generics competition following patent challenges. - International News Service,

Momenta Pharmaceuticals to Present at the Deutsche Bank Small Cap ... Feb 8, 2006
The Company's most advanced product candidate is M-Enoxaparin, a technology-enabled generic version of Lovenox(R). Based on its understanding of complex sugars ... - PharmaLive.com (press release),

Most Extensive Thromboembolic Disease Clinical Trial Program ... Jan 29, 2006
Patients will be divided into different treatment arms involving dabigatran etexilate (RENDIXTM) compared with warfarin or enoxaparin. ... - Medical News Today (press release),

Top drugs help Sanofi-Aventis weather generic impact in Q4 Jan 30, 2006
...at 7 billion euros ($8.5bn), with antiplatelet drug Plavix (clopidogrel) contributing 518 million euros, up 17%, and anticoagulant Lovenox (enoxaparin) rising 9 ... - Pharma Times (subscription),

Momenta Pharmaceuticals to Present at NASDAQ Growth Conference Jan 31, 2006
...products. The Company's most advanced product candidate is M-Enoxaparin, a technology-enabled generic version of Lovenox®. Based ... - Yahoo! News (press release)

As Sharon lays unconscious, debate intensifies over doctors' ... Jan 13, 2006
Doctors at Hadassah Hospital were prescribing the Clexane, or enoxaparin, until they could seal a small hole in Sharon's heart that they said caused the first ... - Combined Jewish Philantropies,

Sharon's treatment after stroke questioned Jan 12, 2006
...said caused Sharon's first stroke. Clexane, or enoxaparin, is sold as Lovenox in the United States. But some experts questioned ... - Miami Herald,

Sharon's Treatment After Stroke Questioned Jan 12, 2006
...hole in Sharon's heart they said caused Sharon's first stroke. Clexane, or enoxaparin, is sold as Lovenox in the United States. - ABC News

Cerebral Amyloid Angiopathy, Found in Sharon, Explains Many ... Jan 13, 2006
For that reason use of blood thinners in the presence of CAA is usually contraindicated, but Sharon’s doctors gave him Clexane (enoxaparin), a low-molecular ... - MedPage Today,

New safety scheme in Tallaght Hospital highlights common drug ... Jan 20, 2006
102 prescribing errors analysed, 22 involved insulin; 14 fentanyl patches; 13 morphine; 13 co-amoxiclav; 12 cefuroxime; 10 diclofenac; 10 enoxaparin; and eight ... - Irish Medical News,

SCCM: Heparin-Xigris Duo Appears Safe for Sepsis Jan 13, 2006
XPRESS (Xigris and Prophylactic Heparin in Severe Sepsis trial, 976 patients were given Xigris plus unfractionated heparin or enoxaparin (Lovenox) and 959 ... - MedPage Today,

Debate intensifies over Sharon doctors’ decisions Jan 13, 2006
...caused Sharon’s first stroke. Clexane, or enoxaparin, is sold as Lovenox in the United States. But some experts questioned that ... - Corvallis Gazette Times,

Other information

Indication
For the treatment of mild to moderate pain, and fever reducing agent

Pharmacology
Acetaminophen, a para-aminophenol analgesic, is the active metabolite of phenacetin. Although, Acetaminophen's analgesic and antipyretic activity is similar to aspirin, Acetaminophen has no peripheral anti-inflammatory activity or effects on platelet function. Acetaminophen is used to treat both acute and chronic pain, on its own or in combination with pseudoephedrine, dextromethorphan, chlorpheniramine, diphenhydramine, doxylamine, codeine, hydrocodone, or oxycodone.

Mechanism Of Action
Acetaminophen is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1 and COX-2, enzymes involved in prostaglandin (PG) synthesis. Unlike NSAIDs, Acetaminophen does not inhibit cyclooxygenase in peripheral tissues and, thus, has no peripheral anti-inflammatory affects.

Drug Category
Analgesics; Antipyretics; ATC:N02BE01

Brand Names/Synonyms
4'-Hydroxyacetanilide; 4'-Hydroxyacetanilide, Paracetamol; APAP; Abenol; Abensanil; Acamol; Accu-Tap; Acephen; Aceta; Aceta Elixir; Aceta Tablets; Acetagesic; Acetalgin; Acetaminofen; Acetaminophen; Acetaminophen Uniserts; Actamin; Actamin Extra; Actamin Super; Actimol Chewable Tablets; Actimol Children's Suspension; Actimol Infants' Suspension; Actimol Junior Strength Caplets; Algotropyl; Allay; Alpiny; Alpinyl; Alvedon; Amacodone; Amadil; Aminofen; Aminofen Max; Anacin; Anacin-3; Anacin-3 Extra Strength; Anaflon; Anapap; Anelix; Anexsia; Anexsia 10/660; Anexsia 5/325; Anexsia 7.5/325; Anexsia 7.5/650; Anhiba; Anoquan; Apacet; Apacet Capsules; Apacet Elixir; Apacet Extra Strength Caplets; Apacet Extra Strength Tablets; Apacet Regular Strength Tablets; Apadon; Apamid; Apamide; Apo-Acetaminophen; Arthritis Pain Formula; Aspirin Free Anacin Maximum Strength Caplets; Aspirin Free Anacin Maximum Strength Gel Caplets; Aspirin Free Anacin Maximum Strength Tablets; Aspirin-Free Excedrin Caplets; Atasol Caplets; Atasol Drops; Atasol Forte Caplets; Atasol Forte Tablets; Atasol Oral Solution; Atasol Tablets; Bancap; Bancap Hc; Banesin; Bayer Select Maximum Strength Headache Pain Relief Formula; Bickie-Mol; Bromo Seltzer; Bucet; Butalbital; Butapap; Calpol; Captin; Cetadol; Clixodyne; Co-Gesic; Conacetol; Dafalgan; Dapa; Dapa X-S; Darvocet; Darvocet-N 100; Darvocet-N 50; Datril; Datril Extra-Strength; Dhc Plus; Dimindol; Dirox; Disprol; Dolene Ap-65; Doliprane; Dolprone; Drixoral Plus; Dularin; Duradyne Dhc; Dymadon; Dypap; Elixodyne; Enelfa; Eneril; Esgic; Esgic-Plus; Eu-Med; Excedrin Caplets; Excedrin Extra Strength Caplets; Exdol; Exdol Strong; Febridol; Febrilix; Febrinol; Febro-Gesic; Febrolin; Femcet; Fendon; Feverall; Feverall Junior Strength; Feverall Sprinkle Caps Junior Strength; Fevor; Finimal; Fioricet; Free; G 1; G-1; Gelocatil; Genapap; Genapap Children's Elixir; Genapap Children's Tablets; Genapap Extra Strength Caplets; Genapap Extra Strength Tablets; Genapap Regular Strength Tablets; Genebs; Genebs Extra Strength Caplets; Genebs Regular Strength Tablets; Genebs X-Tra; Hedex; Homoolan; Hy-Phen; Hydrocet; Infants' Feverall; Injectapap; Janupap; Korum; Lestemp; Liquagesic; Liquiprin; Liquiprin Children's Elixir; Liquiprin Infants" Drops; Lonarid; Lorcet-Hd; Lortab; Lyteca; Lyteca Syrup; Meda; Medigesic Plus; Momentum; Multin; Myapap; NAPA; Napafen; Napap; Naprinol; Nealgyl; Nebs; Neopap; Neotrend; Nobedon; Norcet; Norco; O-Acetaminophenol; Oraphen; Oraphen-Pd; Ortensan; Oxycet; Oxycodone 2.5/Apap 500; Oxycodone 5/Apap 500; P-Acetamidophenol; P-Acetaminophenol; P-Hydroxyacetanilide; P-Hydroxyphenolacetamide; Pacemo; Painex; Paldesic; Panadol; Panadol Extra Strength; Panadol Junior Strength Caplets; Panadol Maximum Strength Caplets; Panadol Maximum Strength Tablets; Panaleve; Panasorb; Panets; Panex; Panofen; Papa-Deine #3; Papa-Deine #4; Paracet; Paracetamol; Paracetamol Dc; Paracetamol Ph Eur; Paracetamole; Paracetamolo; Paracetanol; Parapan; Paraspen; Parelan; Parmol; Pasolind; Pasolind N; Pedric; Percocet; Phenaphen; Phenaphen Caplets; Phendon; Phrenilin; Phrenilin Forte; Prompt; Propacet 100; Proval #3; Pyrinazine; Redutemp; Rivalgyl; Robigesic; Rounox; Roxicet; Roxicet 5/500; Roxilox; Salzone; Sedapap; Servigesic; Sk-Apap; Snaplets-Fr; St. Joseph; St. Joseph Fever Reducer; Suppap; Suppap-120; Suppap-325; Suppap-650; Tabalgin; Talacen; Tapanol; Tapanol Extra Strength Caplets; Tapanol Extra Strength Tablets; Tapar; Tavist Allergy/Sinus/Headache; Temlo; Tempanal; Tempra; Tempra Caplets; Tempra Chewable Tablets; Tempra D.S; Tempra Drops; Tempra Syrup; Tencon; Tibinide; Tibizide; Tisin; Tisiodrazida; Tizide; Tralgon; Triad; Triaprin; Tussapap; Tycolet; Tylenol; Tylenol Arthritis Extended Relief; Tylenol Caplets; Tylenol Children's Chewable Tablets; Tylenol Children's Elixir; Tylenol Drops; Tylenol Elixir; Tylenol Extra Strength Adult Liquid Pain Reliever; Tylenol Extra Strength Caplets; Tylenol Extra Strength Gelcaps; Tylenol Extra Strength Tablets; Tylenol Gelcaps; Tylenol Infants Drops; Tylenol Infants" Suspension Drops; Tylenol Junior Strength Caplets; Tylenol Junior Strength Chewable Tablets; Tylenol Regular Strength Caplets; Tylenol Regular Strength Tablets; Tylenol Tablets; Tylox; Tylox-325; Ultracet; Uniserts; Valadol; Valgesic; Valorin; Valorin Extra; Vicodin; Vicodin Es; Vicodin Hp; Wygesic

Dosage Forms
80 mg per mL (OTC) Atasol Drops Panadol Tempra Drops alcohol 10% Tylenol Drops [Generic] 80 mg per 5 mL (OTC) Atasol Oral Solution Panadol sodium Robigesic alcohol 8.5% Tempra Syrup 160 mg per 5 mL (OTC) Tempra Syrup Tylenol Elixir [Generic]

Absorption
Oral _ Rapid and almost complete

Interactions
Interactions for Acetaminophen:

No information provided.

Chemical IUPAC Name
N-(4-hydroxyphenyl)ethanamide

Chemical Formula
C8H9NO2

Half Life
1-4 hours

Drug Type
Approved Drug

# Accession No
APRD00252

CAS Registry Number
103-90-2