DDAVP: profile and news






Sanofi-Aventis announces gross profits of €5,442 million in Q4 ...  06 Mar 2006
Dehecq said: “Barring major adverse events, and after taking account of the full-year impact of generics of Allegra, Amaryl, Arava, and DDAVP, we expect 2006 ... - Strategiy,

Federal Court Affirms Barr Summary Judgment in DDAVP(R) Patent ...  Feb 15, 2006
...granted summary judgment in favor of its wholly owned subsidiary, Barr Laboratories, Inc., in the Company's challenge to the patent for DDAVP(R) (Desmopressin ... - Black Enterprise,

Barr prevails in DDAVP patent appeal  Feb 15, 2006
15 (UPI) -- Barr Laboratories said Wednesday it got a favorable ruling on appeal in its patent dispute with Ferring and Aventis over DDAVP. ... - United Press International

Sanofi-aventis Reports Strong Growth of 25.7% in 2005 Adjusted EPS ...  Feb 24, 2006
Dehecq said: "Barring major adverse events, and after taking account of the full-year impact of generics of Allegra(R), Amaryl(R), Arava(R), and DDAVP(R), we ... - PR Newswire (press release),

Barr Should Get Earnings Boost From Key Drugs  Feb 6, 2006
Cramer's Take) is expected to report another strong quarter, with continued periods of market exclusivity on its generic Allegra and DDAVP product lines. ... - TheStreet.com

France's Sanofi-Aventis reports 26 percent profit rise in 2005  Feb 24, 2006
...dollars) in sales for the full year because of competition from generics, especially for allergy treatment Allegra, diabetes treatment Amaryl and DDAVP, a drug ... - People's Daily Online,

Sanofi expects Acomplia launch in 06; profits up  Feb 24, 2006
...to four products, the antihistamine Allegra (fexofenadine), diabetes drug Amaryl (glimepiride), Arava (leflunomide) for arthritis and DDAVP (desmopressin). ... - Pharma Times (subscription),

Sanofi-aventis Reports Strong Growth of 25.7% in 2005 Adjusted EPS ...  Feb 24, 2006
...said: "Barring major adverse events, and after taking account of the full-year impact of generics of Allegra®, Amaryl®, Arava®, and DDAVP®, we expect 2006 ... - Yahoo! News (press release)

Membrane trafficking and the regulation of NKCC2  Feb 9, 2006
Subjecting rats to moderate water restriction or DDAVP treatment for 7 days thus results in an increase in the expression of NKCC2 (15). ... - AJP-Renal Physiology

Barr Should Get Earnings Boost From Key Drugs  Feb 6, 2006
Cramer's Take) is expected to report another strong quarter, with continued periods of market exclusivity on its generic Allegra and DDAVP product lines. ... - TheStreet.com

Sanofi-Aventis FY sales 27.311 bln eur, up 9.3 pct; raises FY ...  Jan 29, 2006
Sanofi-Aventis said the decline in sales for products outside the top 15 were due to generic versions of DDAVP and Arava in the US, with sales of both drugs ... - Forbes

Nasal spray can help bed-wetters  Jan 21, 2006
When Billy was 14, I read an Ann Landers column on a woman whose 18-year-old twins had miraculously stopped wetting the bed after using the nasal spray DDAVP. ... - Northwest Herald,

Teva Announces Approval of Desmopressin Acetate Tablets  Jan 29, 2006
Teva's Desmopressin Acetate Tablets are the AB-rated generic equivalent of Aventis' DDAVP(R) Tablets, a product indicated for management of central diabetes ... - International News Service,

FDA approval for Teva's desmopressin acetate tablets  Jan 29, 2006
Teva's desmopressin acetate tablets are the AB-rated generic equivalent of Aventis' DDAVP tablets, a product indicated for management of central diabetes ... - Globes,

Sanofi-aventis Posts Dynamic Growth in 2005 Full-Year Consolidated ...  Jan 30, 2006
This fall was due partly to generics of DDAVP® (down 79.4%) and Arava® (down 79.2%) in the United States, and partly to price reductions in France. ... - Yahoo! News (press release)

Ask the Doctor: Pediatrician addresses bed-wetting issue  Nov 21, 2005
The other treatment is DDAVP, the drug used orally or through the nose, which works quickly, but the relapse rate on stopping the medicine is equally high. ... - Fort Wayne News Sentinel,

Store glasses will help you read tiny type, won't hurt the eyes  Nov 25, 2005
You can also try drugs such as Tofranil, DDAVP or Ditropan, Detrol, Vesicare, Sanctura or Enablex. But bedwetting may recur if the drugs are stopped. - Baltimore Sun,

Is it normal for adults to occasionally wet the bed?  Nov 20, 2005
You can also try drugs such as Tofranil, DDAVP or Ditropan, Detrol, Vesicare, Sanctura, or Enablex. But bed-wetting may recur if the drugs are stopped. - Boston Globe,

Sanofi-aventis Third Quarter 2005: Adjusted EPS(1) up 27.4%, Net ...  Nov 7, 2005
Excluding DDAVP, which faced competition from generics in the United States during the quarter, net sales of other pharmaceutical products were stable. ... - Yahoo! News (press release)

Barr Pharmaceuticals "strong buy," target price raised  Sep 9, 2005
The analyst expects Barr Pharmaceuticals' performance to be robust in FY06 due to the recent launch of the company's major products DDAVP, Videx EC and Allegra ... - New Ratings

Barr Reports GAAP Earnings of $2.03 Per Share for Fiscal 2005 and ...  08 Sep 2005
...products in the fourth quarter of fiscal 2005 were lower than expected due primarily to the timing of FDA approval of the Company's DDAVP(R) (Desmopressin ... - PR Newswire (press release),

Barr Reports GAAP Earnings of $2.03 Per Share for Fiscal 2005 and ...  08 Sep 2005
...in the fourth quarter of fiscal 2005 were lower than expected due primarily to the timing of FDA approval of the Company's DDAVP® (Desmopressin Acetate ... - Yahoo! News (press release)

What can I do to stop bed-wetting?  Aug 23, 2005
In addition, any prescription would have to be supplied by a doctor. For example, you may have heard of a new product called DDAVP nasal spray. ... - GoErie.com,

Pennyroyal can repel insects  Aug 14, 2005
...needs to rule them out. You may want to ask your doctor whether DDAVP (desmopressin) would be helpful. This hormone is prescribed ... - Los Angeles Times,

Back-to-School Bedwetting  Aug 14, 2005
For some children there is a pharmaceutical alternative called DDAVP distributed by Aventis Pharmaceuticals which may be effective. ... - Emediawire (press release),

First-Time Generic Approvals: Rocephin, Sinemet, DDAVP  Jul 8, 2005
On July 1, the FDA approved first-time generic desmopressin acetate 0.1- and 0.2-mg tablets (made by Barr Pharmaceuticals; brand name, DDAVP, made by Aventis ... - Medscape (subscription)

Generic Diabetes Drug Cleared for Sale  Jul 5, 2005
Barr applied for Food and Drug Administration approval in July 2002 in the first application to challenge the patent for the drug, DDAVP, for sales in the ... - New York Times

Urstadt Biddle buys Staples Plaza in Yorktown  Jul 7, 2005
Barr Pharmaceuticals Inc. of Pomona said the FDA has approved its generic version of DDAVP tablets in 0.1 mg. and 0.2 mg. dosages. ... - The Journal News.com

NJ business briefs  Jul 6, 2005
...said it won final US approval to sell a generic version of Sanofi-Aventis SA and Ferring BV's DDAVP diabetes drug, clearing it for sale after a patent dispute ... - NorthJersey.com <**results**>

First-Time Generic Approvals: Rocephin, Sinemet, DDAVP  Jul 8, 2005
On July 1, the FDA approved first-time generic desmopressin acetate 0.1- and 0.2-mg tablets (made by Barr Pharmaceuticals; brand name, DDAVP, made by Aventis ... - Medscape (subscription)

Barr Receives Approval for DDAVP(R) Tablets, 0.1 mg & 0.2 mg  Jul 5, 2005
Barr Laboratories, Inc., has received final approval from the US Food and Drug Administration (FDA) for its generic version of DDAVP® (Desmopressin Acetate ... - Yahoo News (press release)

Barr Gets FDA OK for Antidiuretic Drug  Jul 5, 2005
...unit received final approval from the Food and Drug Administration to market generic versions of DDAVP, an antidiuretic marketed by Aventis, now part of Sanofi ... - Forbes

Generic Diabetes Drug Cleared for Sale  Jul 5, 2005
Barr applied for Food and Drug Administration approval in July 2002 in the first application to challenge the patent for the drug, DDAVP, for sales in the ... - New York Times

Urstadt Biddle buys Staples Plaza in Yorktown  Jul 8, 2005
Barr Pharmaceuticals Inc. of Pomona said the FDA has approved its generic version of DDAVP tablets in 0.1 mg. and 0.2 mg. dosages. ... - The Journal News.com

NJ business briefs  Jul 6, 2005
...said it won final US approval to sell a generic version of Sanofi-Aventis SA and Ferring BV's DDAVP diabetes drug, clearing it for sale after a patent dispute ... - NorthJersey.com

New help for bleeding disorders  Jul 1, 2005
Desmopressin acetate (DDAVP), which comes in a nasal spray or injectable form, increases the body's own production of the Von Willebrand factor. ... - San Antonio Express (subscription),

Ferring Pharmaceuticals Appoints William Garbarini as Senior ...  May 11, 2005
...osteoarthritis. He will continue to be responsible for the out- license relationships of DDAVP (Aventis) and Pentasa (Shire). Garbarini ... - PharmaLive.com

Bells Beat Pills to Stop Bed-Wetting  May 6, 2005
While children who took the drug desmopressen (also known as Concentraid and DDAVP) stopped nighttime bed-wetting faster than those who used the alarms, they ... - WebMD

First-Time Generic Approvals: Terazol 7, DDAVP Nasal Spray, Biaxin ...  Feb 18, 2005
27, the FDA approved a first-time generic formulation of desmopressin acetate nasal solution 0.01% (made by Apotex, Inc.; brand name DDAVP, made by Aventis ... - Medscape (subscription)

Court Grants Barr Summary Judgment in DDAVP(R) Patent Challenge  Feb 13, 2005
...granted summary judgment in favor of its wholly owned subsidiary, Barr Laboratories, Inc., in the Company's challenge to the patents for DDAVP(R) (Desmopressin ... - Chemie.de (press release),


Other information


Indication
For the management of primary nocturnal enuresis and indicated as antidiuretic replacement therapy in the management of central diabetes insipidus and for the management of the temporary polyuria and polydipsia following head trauma or surgery in the pituitary

Pharmacology
Desmopressin is a synthetic analogue of the natural pituitary hormone 8-arginine vasopressin (ADH), an antidiuretic hormone affecting renal water conservation. Desmopressin is indicated as antidiuretic replacement therapy in the management of central diabetes insipidus and for the management of the temporary polyuria and polydipsia following head trauma or surgery in the pituitary region and is also indicated for the management of primary nocturnal enuresis.

Mechanism Of Action
Desmopressin emulates the actions of the natural pituitary hormone 8-arginine vasopressin (ADH).

Drug Category
Renal Agents; Hemostatics (20:12.16); Pituitary (68:28.00); ATC:H01BA02

Brand Names/Synonyms
DESMOPRESSIN; Desmopresina [INN-Spanish]; Desmopressine [INN-French]; Desmopressinum [INN-Latin]; 1-Deamino-8-D-arginine vasopressin; 1-Desamino-8-D-arginine vasopressin; 1-Desamino-8-d-arginine-vasopressin; Desamino-8-D-arginine vasopressin, l-; Concentraid; DDAVP; Stimate

Dosage Forms
TABLET

Absorption
Not Available

Interactions
Interactions for Desmopressin: Although the pressor activity of Desmopressin is very low compared to its antidiuretic activity, large doses of Desmopressin Tablets should be used with other pressor agents only with careful patient monitoring.

Chemical IUPAC Name
1-[[13-benzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-4-yl]carbonyl]-N-[1-(carbamoylmethylcarbamoyl)-4-guanidino-butyl]-pyrrolidine-2-carboxamide

Chemical Formula
C46H64N14O12S2

Half Life
1.5-2.5 hours

Drug Type
Approved Drug

# Accession No
BIOD00112

CAS Registry Number
16679-58-6

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