Cetuximab: profile and news
Searching for Osteoarthritis Pain Relief? 06 Mar 2006
Excess acetaminophen can cause damage to the liver. Acetaminophen is also found in other pain medications such as Darvocet, Percocet, and Tylenol Cold. ... - DailyIndia.com,
Expert Warns of Overuse of Over-the-Counter Pain Medication 06 Mar 2006
...among people who take Tylenol or a similar medication in addition to a prescription pain reliever that also contains acetaminophen, such as Vicodin or Darvocet ... - Newswise (press release)
Group seeks federal ban on Darvocet Feb 28, 2006
WASHINGTON -- Darvon, Darvocet and related painkillers should be phased out and eventually banned, a watchdog group said Tuesday in a government petition that ... - Seattle Post Intelligencer
Watchdog group seeks federal ban on Darvocet and related ... Feb 28, 2006
The director of the Public Citizen's Health Research Group says the main ingredient in drugs like Darvon and Darvocet, propoxyphene (proh-PAHKS'-uh-feen), is a ... - KXAN-TV,
Darvocet, Others Should Be Off Market, Group Says Feb 28, 2006
The director of the Public Citizen's Health Research Group said the main ingredient in drugs like Darvon and Darvocet, propoxyphene, is a relatively weak ... - Champlain Channel.com,
Group Seeks Federal Ban on Darvocet Feb 28, 2006
WASHINGTON - Darvon, Darvocet and related painkillers should be phased out and eventually banned, a watchdog group said Tuesday in a government petition that ... - Brocktown News,
Health briefs Mar 5, 2006
The consumer group Public Citizen is urging the federal Food and Drug Administration to ban the prescription pain reliever commonly sold as Darvon or Darvocet. ... - Chicago Sun-Times,
Group Seeks Federal Ban on Darvocet Feb 28, 2006
...(AP) Darvon, Darvocet and related painkillers should be phased out and ... Darvocet, which combines propoxyphene with acetaminophen, is among the best known. ... - CBS News
Group Seeks Federal Ban on Darvocet Feb 28, 2006
WASHINGTON Feb 28, 2006 (AP)— Darvon, Darvocet and related painkillers should be phased out and eventually banned, a watchdog group said Tuesday in a ... - ABC News
Darvocet, Others Should Be Off Market, Group Says Feb 28, 2006
WASHINGTON -- Darvon, Darvocet and related painkillers were associated with the deaths of at least 2,110 people between 1981 and 1999, critics said Tuesday in ... - Channel Oklahoma.com,
EEO Public File Report Mar 2, 2006
It's no secret to him he's surrounded by medications that are potentially misused--one in particular Darvocet. Freudenberg said,"The ... - WTHI,
Ban Sought On Some Painkillers Feb 28, 2006
...(AP) Darvon, Darvocet and related painkillers were associated with the ... Darvocet, which combines propoxyphene with acetaminophen, is among the best known. ... - CBS News
Group Blames Darvon for Thousands of Deaths, Seeks Ban Mar 1, 2006
Propoxyphene, sold as Darvon or Darvocet, is converted into a metabolite that is highly toxic to the heart and lasts longer in the body than the original ... - Daily News Central,
Pain drug too deadly, group says Feb 28, 2006
...over two decades, a consumer group called Tuesday for the Food and Drug Administration to ban the prescribed pain reliever commonly sold as Darvon or Darvocet. ... - USA Today
Group asks FDA to phase out Darvon Feb 28, 2006
28 (UPI) -- Public Citizen petitioned federal regulators Tuesday to take the painkiller sold as Darvon and Darvocet off the market in the United States. ... - United Press International
Consumer Watchdog Group, Public Citizen, Petitions FDA to Ban All ... Mar 1, 2006
...to immediately begin the phased removal from the market of propoxyphene (Darvon) and all propoxyphene-containing products such as Darvocet (propoxyphene and ... - Newsinferno.com,
Group Seeks Ban on Some Painkillers Feb 28, 2006
WASHINGTON, Feb. 28 (AP) — Darvon, Darvocet and related painkillers should be phased out and eventually banned, a watchdog group said Tuesday. ... - New York Times,
Group Says Some Painkillers Should Be Banned Feb 28, 2006
WASHINGTON (AP) -- The director of the Public Citizen's Health Research Group says the main ingredient in drugs like Darvon and Darvocet, propoxyphene, is a ... - WCSH-TV,
Public Citizen Demands FDA to Ban Darvon Products Feb 28, 2006
...the US Food and Drug Administration (FDA) to immediately begin to phase out the widely prescribed pain reliever propoxyphene (Darvon, Darvocet and generic ... - Playfuls.com,
Arthritis Blog Archives Mar 1, 2006
Yet a group known as Public Citizen is petitioning the Food and Drug Administration (FDA) to ban the drugs more commonly known as Darvon, Darvocet, and Wygesic ... - About - News & Issues,
Popular painkiller linked to 2000 deaths Mar 1, 2006
The group says the widely prescribed pain reliever propoxyphene (Darvon, Darvocet and generic versions), should be phased out because it has been associated ... - News-Medical.net,
PAINKILLERS KILL PEOPLE, TOO: CRITICS Mar 1, 2006
March 1, 2006 -- Darvon, Darvocet and related painkillers were associated with the deaths of at least 2,110 people from 1981 to 1999, critics said yesterday in ... - New York Post,
'Take Darvon and generic versions off US market', FDA petitioned Mar 1, 2006
In its petition, the group explains that propoxyphene, selling under brand names such as Darvon, Darvocet, etc., is the 12th most commonly prescribed drug in ... - Earthtimes.org
Ban Darvon and Related Painkillers: Public Citizen Mar 1, 2006
...of at least 2,110 people in the United States between 1981 and 1999, the watchdog group Public Citizen has called for a ban on Darvon, Darvocet and related ... - HealthCentral.com
Group urges Darvon, others be phased out Mar 1, 2006
WASHINGTON -- Darvon, Darvocet, and related painkillers should eventually be banned, a group said yesterday in a government petition that cited the accidental ... - Boston Globe,
Drug-addicted doctor sent back to prison for 2 years Feb 23, 2006
Greer, 41, turned himself in to his probation officer this month after a binge on a generic equivalent of the prescription painkiller Darvocet between Jan. ... - Shreveport Times,
Greer sentenced to two more years in prison Feb 22, 2006
Greer, 41, turned himself into his probation officer this month for a binge on a generic equivalent of Darvocet between Jan. 27 and Feb. ... - Shreveport Times,
US group petitions FDA to ban pain drug Feb 28, 2006
...manufacture generic versions of the drug. Privately-held Xanodyne also sells it as Darvocet, a combination drug that includes acetaminophen. ... - Reuters.uk,
UPDATE 1-US group petitions FDA to ban pain drug Feb 28, 2006
...calls seeking comment. Privately held Xanodyne also sells it as Darvocet, a combination drug that includes acetaminophen. "No good ... - Reuters
Public Citizen Petitions FDA to Ban Darvon Feb 28, 2006
Public Citizen said that propoxyphene (Darvon, Darvocet and generic versions) has been associated with more than 2,000 accidental deaths and is physically ... - Consumer Affairs
Cato Daily Dispatch for March 1, 2006 Mar 1, 2006
...growth.". "Darvon, Darvocet and related painkillers should be phased out and eventually banned, a watchdog group said Tuesday. At ... - Cato Institute,
Fremont man arrested on drug charges Feb 16, 2006
...counts of possession with the intent to deliver a controlled substance-marijuana and one count of distribution of a controlled substance-Darvocet, all Class ... - Fremont Tribune,
Brad Garrett stands up Feb 21, 2006
You should see what I'm eating right now -- a cheddar and jalapeño bagel, backed up with banana muffin. And I think these are Darvocet. I'm kidding. ... - San Jose Mercury News,
Doctor headed back to court over drugs Feb 22, 2006
According to court documents, the convicted felon admitted to abusing a generic equivalent of painkiller Darvocet between Jan. 27 and Feb. ... - Shreveport Times,
NEWS DIGEST Feb 25, 2006
...simple possession of controlled substance. David A. Koontz, 24, allegedly tried to sell Darvocet to others at the shelter on Jan. 6. - Chambersburg Public Opinion,
Caution needed to prevent accidental acetaminophen overdose Feb 4, 2006
...lot of times people accidentally overdose on acetaminophen because they don’t realize that it is in prescription medicines too, such as Darvocet,� said Ron ... - Kearney Hub,
Pastor facing charges Feb 11, 2006
..."What happened was, (Reed) used the name of one of his parishioners who is a doctor," Ebert said. "And he managed to pick up three prescriptions for Darvocet. ... - News-Herald.com,
Minister Poses As Doctor To Get Prescription Painkillers Feb 10, 2006
Narcotics investigators say Reed posed as his former doctor, and used information stolen from the physician's office to call in prescriptions for Darvocet at a ... - NewsNet5.com,
Two Indiana men plead guilty of anhydrous ammonia theft Feb 3, 2006
Amanda Y. DeWeese, 22, entered a negotiated guilty plea to a Class 4 felony charge for the unlawful possession of Darvocet, a prescription pain reliever. ... - Paris Beacon News (subscription),
Other information
Indication
For treatment of metastatic colorectal cancer
Pharmacology
Used in the treatment of colorectal cancer, Erbitux binds specifically to the epidermal growth factor receptor (EGFr, HER1, c-ErbB-1) on both normal and tumor cells. EGFr is over-expressed in many colorectal cancers. Erbitux competitively inhibits the binding of epidermal growth factor (EGF) and other ligands, such as transforming growth factor–alpha. Binding of Erbitux to the EGFr blocks phosphorylation and activation of receptor-associated kinases, resulting in inhibition of cell growth, induction of apoptosis, decreased matrix metalloproteinase secretion and reduced vascular endothelial growth factor production.
Mechanism Of Action
Erbitux binds to the epidermal growth factor receptor (EGFr) on both normal and tumor cells. EGFr is over-expressed in many colorectal cancers. Erbitux competitively inhibits the binding of epidermal growth factor (EGF) and TGF alpha, thereby reducing their effects on cell growth and metastatic spread.
Drug Category
Antineoplastic Agents
Brand Names/Synonyms
Ig gamma-1 chain C region; Anti EGFR; Erbitux (ImClone Systems Inc)
Dosage Forms
Not Available
Absorption
Not Available
Interactions
Not Available
Chemical IUPAC Name
Humanized anti-EGF receptor (EGFr) antibody
Chemical Formula
C6484H10042N1732O2023S36 >Anti-EGFR light chain 1 >Anti-EGFR heavy chain 2 >Anti-EGFR light chain 2
Half Life
114 hrs
Drug Type
Approved Drug
# Accession No
BIOD00071
CAS Registry Number
205923-56-4