Cetrotide: profile and news

AEterna Zentaris Regains Exclusive Worldwide (ex-Japan) Rights for ... Jan 30, 2006
Cetrorelix is also marketed under the brand name Cetrotide(R), the first LHRH-antagonist approved for therapeutic use as part of in vitro fertilization ... - Canada NewsWire (press release),

Serono Shares Drop on Report It Didn't Get Offers (Update1) Jan 24, 2006
...products apart from Rebif are psoriasis medicine Raptiva, ovulation hormone Ovidrel, progesterone gel Crinone, ovulation control hormone Cetrotide and growth ... - Bloomberg

AEterna Zentaris Announces Completion of Patient Enrollment for ... Aug 29, 2005
The lead LHRH antagonist compound, cetrorelix, is currently marketed for in vitro fertilization under the brand name Cetrotide®. ... - Yahoo News (press release)

Is There Still Hope After 40? Aug 24, 2005
...oral contraceptive, an oral contraceptive/Lupron flare, and a gonadotropin-releasing hormone (GnRH) antagonist protocol, which included Cetrotide or Antagon. ... - Fertility Neighborhood,

AEterna Zentaris Reports 2005 Second Quarter Financial and ... Aug 3, 2005
The lead LHRH antagonist compound, cetrorelix, is currently marketed for in vitro fertilization under the brand name Cetrotide®. ... - Yahoo News (press release)

AEterna Zentaris' Partner Spectrum Granted IND from FDA to Conduct ... May 31, 2005
The lead LHRH antagonist compound, cetrorelix, is currently marketed for in vitro fertilization under the brand name Cetrotide®. ... - Yahoo News (press release)

AEterna Zentaris Expands Therapeutic Approaches in Oncology to ... Apr 21, 2005
The lead LHRH antagonist compound, cetrorelix, is currently marketed for in vitro fertilization under the brand name Cetrotide(R). Cetrorelix is also in late ... - Canada NewsWire

COMUNICADO: AEterna Zentaris Receives First Regulatory Approval ... Mar 29, 2005
With two products on the market generating revenues, Cetrotide(R)and Impavido(R), we are further establishing a solid financial basis to support the ... - Europa Press,

AEterna Zentaris Reports 2004 Fourth Quarter and Full-Year ... Feb 28, 2005
The lead LHRH antagonist compound, cetrorelix, is currently marketed for in vitro fertilization under the brand name Cetrotide(R), and has successfully ... - Yahoo News (press release)

Other information

Indication
For the inhibition of premature LH surges in women undergoing controlled ovarian stimulation.

Pharmacology
Cetrorelix is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity. GnRH induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the gonadotrophic cells of the anterior pituitary. Due to a positive estradiol (E2) feedback at midcycle, GnRH liberation is enhanced resulting in an LH-surge. This LH-surge induces the ovulation of the dominant follicle, resumption of oocyte meiosis and subsequently luteinization as indicated by rising progesterone levels. Cetrorelix competes with natural GnRH for binding to membrane receptors on pituitary cells and thus controls the release of LH and FSH in a dose-dependent manner.

Mechanism Of Action
Cetrorelix binds to the gonadotropin releasing hormone receptor and acts as a potent inhibitor of gonadotropin secretion. It competes with natural GnRH for binding to membrane receptors on pituitary cells and thus controls the release of LH and FSH in a dose-dependent manner.

Drug Category
Infertility Agents; Hormone Antagonists; ATC:H01CC02

Brand Names/Synonyms
Cetrorelix; Cetrorelix Acetate; Cetrorelix [Inn]; Cetrorelixum [Inn-Latin]; Cetrotide; Cetyl Pyridinium Bromide; Cetyl Pyridinium Chloride; Cetyl Pyridinium Chloride for Synthesis; Cetylpyridinium Chloride Monohydrate; Chondroitin Hydrochloride; Hexadecyl Pyridinium Bromide; Hexadecylpyridinium Chloride Monohydrate; N-Cetylpyridinium Bromide; N-Hexadecylpyridinium Bromide; Pyrisept; SB-75

Dosage Forms
POWDER FOR SOLUTION

Absorption
Rapidly absorbed following subcutaneous injection. The mean absolute bioavailability following subcutaneous administration to healthy female subjects is 85%.

Interactions
-->Interactions for Cetrorelix:

No formal drug interaction studies have been performed with Cetrotide^®.

Chemical IUPAC Name
Not Available

Chemical Formula
Not Available

Half Life
~62.8 hours

Drug Type
Approved Drug

# Accession No
APRD00686

CAS Registry Number
120287-85-6