Cetirizine: profile and news






HUGIN NEWS/UCB Receives EMEA Positive Opinion and FDA Approvable ...  Feb 2, 2006
UCB key products are Keppra® (levetiracetam), Zyrtec®* (cetirizine HCl), Tussionex® CIII (hydrocodone polistirex/chlorpheniramine polistirex), and Equasym(TM ... - FinanzNachrichten.de,

Epilepsy - UCB Receives EMEA Positive Opinion And FDA Approvable ...  Feb 5, 2006
UCB key products are Keppra® (levetiracetam), Zyrtec®* (cetirizine HCl), Tussionex® CIII (hydrocodone polistirex/chlorpheniramine polistirex), and Equasym(TM ... - Medical News Today (press release),

You may not be able to find your favorite decongestant  Dec 6, 2005
In the drug realm, antihistamines such as diphenhydramine (Benadryl), chlorpheniramine (Chlor-Trimeton), cetirizine (Zyrtec), and loratadine (Claritin) can ... - DetNews.com,

New Therapies on the Horizon for Allergic Rhinitis  Nov 30, 2005
In a recent study which compared azelastine with oral cetirizine, azelastine significantly improved the total nasal symptom score (TNSS), 29.3 percent vs. ... - Newswise (press release)

UCB's Anti-Epileptic Keppra(R) Meets Primary End-Point in ...  Sep 15, 2005
UCB's key products in the US are Keppra® (levetiracetam), Zyrtec®(1) (cetirizine HCl), Tussionex® CIII (hydrocodone polistirex/chlorpheniramine polistirex ... - Yahoo! News (press release)

UCB's Anti-Epileptic Keppra(R) Meets Primary End-Point in ...  Sep 15, 2005
UCB's key products in the US are Keppra(R) (levetiracetam), Zyrtec(R)(1) (cetirizine HCl), Tussionex(R) CIII (hydrocodone polistirex/chlorpheniramine polistirex ... - PR Newswire (press release),

Many meds don't mix with the sun  Sep 21, 2005
Orinase). Antihistamines: Cetirizine (Zyrtec), cyproheptadine (Periactin), diphenhydramine (Bena-dryl), loratadine (Claritin). Anti ... - Pioneer Press,

Study: Herb helps hay fever  Aug 22, 2005
...a 2002 study in the British Journal of Medicine finding that butterbur had similar curative effects and reduced drowsiness relative to cetirizine, another non ... - Science Daily (press release)

Butterbur: leaf extract yields positive hayfever results  Aug 22, 2005
In a study published in the British Medical Journal in January 2002, he showed it to be as effective as cetirizine. Despite cetirizine ... - Food Navigator -USA,

Complications From Olanzapine in a Mentally Healthy Patient  Aug 31, 2005
Mr. A, a 36-year-old man with chronic seasonal allergies, was given a prescription for cetirizine, 10 mg bid, to be taken on an as-needed basis for his allergy ... - Am J Psychiatry (subscription)

Old wine in new bottles  Aug 28, 2005
The formula of the anti-allergic medicine, incidal, has been changed from mebhydrolin (to be taken 3-4 times daily) to cetirizine (taken only once daily). ... - Financial Express,

Certolizumab pegol, positive results in two Phase III Crohn'™s ...  Jul 26, 2005
UCB'TMs key products in the US are Keppra® (levetiracetam), Zyrtec®' (cetirizine HCl), Tussionex® CIII (hydrocodone polistirex/chlorpheniramine polistirex ... - Medical News Today (press release)

Certolizumab Pegol Demonstrates Positive Results in Two Phase III ...  Jul 26, 2005
UCB's key products in the US are Keppra® (levetiracetam), Zyrtec®(t) (cetirizine HCl), Tussionex® CIII (hydrocodone polistirex/chlorpheniramine polistirex ... - ArriveNet (press release)

Certolizumab Pegol Demonstrates Positive Results in Two Phase III ...  Jul 27, 2005
UCB's key products in the US are Keppra(R) (levetiracetam), Zyrtec(R)(+) (cetirizine HCl), Tussionex(R) CIII (hydrocodone polistirex/chlorpheniramine polistirex ... - PharmaLive.com (press release)

Over the counter: antihistamines  Jul 8, 2005
But generic versions of the same treatments — chlorphenamine, cetirizine and loratadine (all available OTC) — are £1.20 for 28, £2.54 for 30 and £1.98 ... - Times Online

Allergy skin tests: Identify the sources of your sneezing  Jul 11, 2005
Medications that can interfere with skin tests include: 1. Prescription nonsedating antihistamines, such as fexofenadine (Allegra) and cetirizine (Zyrtec). ... - Afternoon Dispatch & Courier <**results**>

Allergy skin tests: Identify the sources of your sneezing  11 Jul 2005
Medications that can interfere with skin tests include: 1. Prescription nonsedating antihistamines, such as fexofenadine (Allegra) and cetirizine (Zyrtec). ... - Afternoon Dispatch & Courier

Over the counter: antihistamines  Jul 8, 2005
But generic versions of the same treatments — chlorphenamine, cetirizine and loratadine (all available OTC) — are £1.20 for 28, £2.54 for 30 and £1.98 ... - Times Online

FDA Approves UCB's Keppra(R) for Use in Childhood Epilepsy  Jun 27, 2005
UCB's key products in the US are Keppra(R) (levetiracetam), Zyrtec(R)+ (cetirizine HCl), Tussionex(R) CIII (hydrocodone polistirex/chlorpheniramine polistirex ... - dBusinessNews Atlanta (press release)

A Question Of Health  Jun 28, 2005
Her answer was simple: "No". I discovered that a similar price discrepancy exists with another popular antihistamine, cetirizine. ... - Independent

Fewer Prescriptions, Lower Costs Follow Claritin's OTC Switch, USA  Jun 12, 2005
...antihistamines before the switch. This class of drugs also includes cetirizine (Zyrtec) and fexofenadine (Allegra). The drugs treat ... - Medical News Today

FDA Approves UCB's Keppra(R) for Use in Childhood Epilepsy  Jun 24, 2005
UCB's key products in the US are Keppra® (levetiracetam), Zyrtec®† (cetirizine HCl), Tussionex® CIII (hydrocodone polistirex/chlorpheniramine polistirex ... - ArriveNet (press release)

Allergy medications: Know your options  Jun 25, 2005
Another prescription antihistamine, cetirizine (Zyrtec), has an intermediate risk of causing drowsiness or driving impairment. Nasal sprays. ... - MayoClinic.com

FDA Approves UCB's Keppra(R) for Use in Childhood Epilepsy  13 Sep 2002
UCB's key products in the US are Keppra(R) (levetiracetam), Zyrtec(R)+ (cetirizine HCl), Tussionex(R) CIII (hydrocodone polistirex/chlorpheniramine polistirex ... - dBusinessNews Atlanta (press release),

FDA Approves UCB's Keppra(R) for Use in Childhood Epilepsy  Jun 24, 2005
UCB's key products in the US are Keppra® (levetiracetam), Zyrtec®† (cetirizine HCl), Tussionex® CIII (hydrocodone polistirex/chlorpheniramine polistirex ... - ArriveNet (press release),

Allergy medications: Know your options  Jun 25, 2005
Another prescription antihistamine, cetirizine (Zyrtec), has an intermediate risk of causing drowsiness or driving impairment. Nasal sprays. ... - MayoClinic.com

Fewer Prescriptions, Lower Costs Follow Claritin's OTC Switch, USA  Jun 12, 2005
...antihistamines before the switch. This class of drugs also includes cetirizine (Zyrtec) and fexofenadine (Allegra). The drugs treat ... - Medical News Today,

What Makes a Drug "OTC"? The Case of Plan B  Jun 3, 2005
...by a health insurance company, WellPoint Health Networks of California, which wanted to see Allegra (fexofenadine), Zyrtec (cetirizine), and Claritin ... - Medscape (subscription)

FDA Sends Pfizer Warning Letter Over Zyrtec Advertisements  Apr 26, 2005
...allergy medicine not working?" (office) (ID #ZY182060A) and "Maybe it's time to switch allergy medicines" (ID #ZY182060) for Zyrtec® (cetirizine HCI) Tablets ... - PharmaLive.com

Allergies: The new anti-aphrodisiac  Apr 7, 2005
J. Bousquet et al (Improvement of quality of life by treatment with cetirizine in patients with perennial allergic rhinitis. J Allergy ... - Canada NewsWire

Itching for Some Allergy Relief?  Apr 1, 2005
Zyrtec (cetirizine), also available by prescription, has sedation frequency slightly higher than the relatively non-sedating antihistamines mentioned above. ... - FDA.gov

Health Northwest: Dealing with springtime allergies  Mar 25, 2005
Clarinex). Most prescription antihistamines don’t cause drowsiness; these include fexofenadine (Allegra) and cetirizine (Zyrtec). ... - The Daily Astorian (subscription),

Hives : Skin Problems : Causes, Cure and Removal.  Mar 23, 2005
What can be done to prevent the condition? Antihistamine medications, such as diphenhydramine, cetirizine or loratadine, can be used to prevent hives. ... - Khalsa News Network,


Other information


Indication
For the relief of symptoms associated with seasonal allergic rhinitis, perennial allergic rhinitis and the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria

Pharmacology
Cetirizine, the active metabolite of the piperazine H1-receptor antagonist hydroxyzine, is used to treat chronic idiopathic urticaria, perennial allergic rhinitis, seasonal allergic rhinitis, allergic asthma, physical urticaria, and atopic dermatitis.

Mechanism Of Action
Cetirizine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The low incidence of sedation can be attributed to reduced penetration of cetirizine into the CNS as a result of the less lipophilic carboxyl group on the ethylamine side chain.

Drug Category
Anti-allergic Agents; Antihistamines; ATC:R06AE07; ATC:R06AE09

Brand Names/Synonyms
Alerlisin; CHEMBANK1856; Cetirizina [Spanish]; Cetirizine; Cetirizinum [Latin]; Cetrizine Hcl; Cetryn; Formistin; Hitrizin Film Tablet; Reactine; Setir; Virlix; Ziptek; Zirtek; Zyrlex; Zyrtec

Dosage Forms
tablets

Absorption
mean peak plasma concentration (Cmax) of 114 ng/mL at a time (Tmax) of 2.2 hours postdose was observed for cetirizine

Interactions
Interactions for Cetirizine:

Pharmacokinetic interaction studies with cetirizine in adults were conducted with pseudoephedrine, antipyrine, ketoconazole, erythromycin and azithromycin. No interactions were observed. In a multiple dose study of theophylline (400 mg once daily for 3 days) and cetirizine (20 mg once daily for 3 days), a 16% decrease in the clearance of cetirizine was observed. The disposition of theophylline was not altered by concomitant cetirizine administration.

Drug-Drug Interactions: No clinically significant drug interactions have been found with theophylline at a low dose, azithromycin, pseudoephedrine, ketoconazole, or erythromycin. There was a small decrease in the clearance of cetirizine caused by a 400-mg dose of theophylline; it is possible that larger theophylline doses could have a greater effect.



Chemical IUPAC Name
2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]aceticacid

Chemical Formula
C21H25ClN2O3

Half Life
8.3 hours

Drug Type
Approved Drug

# Accession No
APRD00630

CAS Registry Number
83881-51-0

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