Cephalexin: profile and news






Advancis Pharmaceutical Reports Fourth Quarter and Full Year 2005 ...  Feb 9, 2006
Product Sales - Keflex(R) (cephalexin capsules, USP) Advancis reported net Keflex sales of $1.6 million in the fourth quarter of 2005, up from $1.3 million in ... - PR Newswire (press release),

Advancis Pharmaceutical Strengthens Sales and Marketing Capability ...  Feb 28, 2006
Keflex(R) (cephalexin capsules, USP) is a first-generation cephalosporin antibiotic shown to be active against strains of both gram-positive and gram- negative ... - PharmaLive.com (press release),

GeoPharma Reports 80% Increase in Third Quarter 2006 Revenues; EPS ...  Feb 1, 2006
Additions to our Cephalexin plant are progressing and the Consolidated Pharmaceutical facility we acquired in August is on track for FDA inspection and the ... - PR Newswire (press release),

Strep throat grows stronger  Feb 3, 2006
By contrast, 14 percent of children receiving older generation cephalosporin antibiotics such as cephalexin, and only 7 percent of children receiving newer ... - Quad City Times,

Necrotizing Fasciitis in a Patient with Type 2 Diabetes Mellitus  Feb 9, 2006
...remained afebrile. She was discharged on hospital day 14 with a prescription for cephalexin, 500 mg, four times a day for 10 days. The ... - Journal of the American Podiatric Medical Association

Advancis Pharmaceutical Reports Fourth Quarter and Full Year 2005 ...  09 Feb 2006
Product Sales - Keflex(R) (cephalexin capsules, USP) Advancis reported net Keflex sales of $1.6 million in the fourth quarter of 2005, up from $1.3 million in ... - PR Newswire (press release),

Health Groups Raising Awareness on Misuse of Antibiotics  Jan 25, 2006
Meijer pharmacies are collecting Amoxicillan, Zithromax, Cephalexin and other antibiotics that are used to treat bacterial infections. ... - WLNS,

Hikma part-owned plant given FDA approval  Jan 25, 2006
The group said the "US FDA has approved its Abbreviated New Drug Application (ANDA) filings for the oral cephalosporin, Cephalexin in 250mg and 500 mg capsule ... - ShareCast,

GeoPharma Reports 80% Increase in Third Quarter 2006 Revenues; EPS ...  Feb 1, 2006
Additions to our Cephalexin plant are progressing and the Consolidated Pharmaceutical facility we acquired in August is on track for FDA inspection and the ... - PR Newswire (press release),

Strep throat grows stronger  Feb 3, 2006
By contrast, 14 percent of children receiving older generation cephalosporin antibiotics such as cephalexin, and only 7 percent of children receiving newer ... - Quad City Times,

Kids tee off  Jan 10, 2006
By contrast, 14 percent of children receiving older- generation cephalosporin antibiotics such as cephalexin, and only 7 percent of children receiving newer ... - Indianapolis Star,

Underground resistance  Jan 19, 2006
More than 90 percent were resistant to cephalexin, used to treat pneumonia and urinary tract infections, and one in 10 resisted the anti-anthrax drug ... - Newsday,

Retapamulin demonstrates promising activity against pathogens ...  Jan 10, 2006
...the potential for S. aureus to develop resistance to Retapamulin and seven other commonly-used antibacterials, including Mupirocin, Cephalexin, Vancomycin and ... - Xagena.it,

Stock Watch  Jan 24, 2006
It received two ANDA approvals viz. for Lisinopril Tablets and Cephalexin suspension respectively during the quarter under review. ... - Express Pharma Pulse,

Lupin gets USFDA nod for Cephalexin  Nov 30, 2005
Lupin Ltd has announced that the company has received USFDA approval for its Abbreviated New Drug Application (ANDA) for Cephalexin Capsules USP 250 mg and 500 ... - Sify,

Lupin gets USFDA nod for Cephalexin  Dec 1, 2005
Lupin Ltd on Thursday said it has received USFDA approval for its Abbreviated New Drug Application for multiple strengths of antibiotic Cephalexin capsules. ... - Rediff,

Lupin receives USFDA approval for Cephalexin capsules  Dec 1, 2005
Lupin Ltd has received USFDA approval for its abbreviated new drug application (ANDA) for Cephalexin Capsules USP 250 mg and 500 mg. ... - Myiris.com,

Lupin receives USFDA approval for Cephalexin Capsules  Dec 1, 2005
The US market for Cephalexin capsules is estimated at US 80 million dollars. Earlier this year, the company had received approvals ... - Webindia123,

Lupin receives US FDA approval for Cephalexin capsules  Dec 1, 2005
Lupin Ltd has received US FDA approval for its abbreviated new drug application (ANDA) for Cephalexin capsules USP 250mg and 500mg. ... - domain-B,

Aurobindo gets US FDA approval for Cephalexin  Nov 20, 2005
Aurobindo Pharma Ltd has announced that US Food Drug Administration (US FDA) has approved its Cephalexin capsules USP 250 mg & 500 mg. ... - Sify,

Aurobindo gets FDA nod for cephalexin capsules  Nov 21, 2005
Aurobindo Pharma Limited has announced that the US Food and Drug Administration (US FDA) has approved its cephalexin capsules 250 mg and 500 mg. ... - Business Standard,

Aurobindo Pharma gets nod for Cephalexin  Nov 21, 2005
Aurobindo Pharma Ltd. announced on Monday that the US Food Drug Administration (US FDA) has approved its Cephalexin capsules USP 250 mg and 500 mg. ... - India Infoline.com,

USFDA approval for Aurobindo's Cephalexin  Nov 21, 2005
The US Food Drug Administration (US FDA) has approved the Cephalexin capsules USP 250 mg & 500 mg. of Aurobindo Pharma Ltd. This ... - Andhra Cafe,

Lupin gets nod for antibiotic Cephalexin  Dec 1, 2005
...on Thursday that it has received US Food and Drug Administration (FDA) approval for its Abbreviated New Drug Application (ANDA) for Cephalexin Capsules USP 250 ... - India Infoline.com,

Real growth will happen from 2007: Orchid  Dec 10, 2005
...| Read more Finance news. |. Three of its Cephalosporin-based formulations are selling in the US markets - Cefazolin, Cephalexin and Ceftriaxone. ... - Sify,

Weekly wrap: Sensex breaches 9000 mark  Dec 2, 2005
Lupin Ltd received USFDA approval for its abbreviated new drug application (ANDA) for Cephalexin Capsules USP 250 mg and 500 mg. ... - Myiris.com,

Aurobindo gets USFDA approval  Nov 20, 2005
MUMBAI: Aurobindo Pharma on Monday said it has received the US Food Drug Administration (US FDA) approval for its Cephalexin capsules USP 250 mg and 500 mg. ... - Economic Times,

Market trades weak  Nov 21, 2005
Aurobindo Pharma Ltd has received approval from the US Food Drug Administration (US FDA) to market its Cephalexin capsules USP 250 mg & 500 mg. ... - Myiris.com,

Sensex closes in negative territory  Nov 21, 2005
Aurobindo Pharma was down 0.15% (Rs 342.35), it has received approval from the US FDA to market its Cephalexin capsules USP 250 mg & 500 mg. ... - Myiris.com,

Aurobindo Pharma gets nod from US FDA  Nov 21, 2005
Aurobindo Pharma Ltd has received approval from the US Food Drug Administration (US FDA) to market its Cephalexin capsules USP 250 mg & 500 mg. ... - Myiris.com,

Indices bounce back strongly from yesterday's fall  Dec 1, 2005
...per share. Lupin Labs has informed the exchanges that the company has received US FDA approval for cephalexin in tablet form. The ... - domain-B,

Indices finally stump the uprising on profit booking  Nov 21, 2005
...crore. Aurobindo Pharma has informed the exchanges that the company has received US FDA approval for cephalexin in capsule form. ... - domain-B,

Dear Doctor: How does MRSA spread?  Nov 22, 2005
Oral drugs such as cephalexin (Keflex) and amoxicilin/pot clavulana (Augmentin), which had previously worked promptly, could not stem the worsening infections ... - Pittsburgh Post Gazette,

Advancis Pharmaceutical to Conduct Additional Adult Amoxicillin ...  Sep 15, 2005
Sale of Keflex Brand Advancis also announced that it has reached an agreement in principle to sell the US rights to the Keflex(R) brand of cephalexin to a ... - PR Newswire (press release),

Advancis Starting Another Trial, Selling Keflex Rights For $12M  Sep 15, 2005
Trimming its sails, Advancis is selling off US rights to its Keflex brand of cephalexin, acquired for $11 million last year from Indianapolis-based Eli Lilly ... - BioWorld Online (subscription),

Advancis Pharmaceutical to Conduct Additional Adult Amoxicillin ...  Sep 15, 2005
Advancis also announced that it has reached an agreement in principle to sell the US rights to the Keflex(R) brand of cephalexin to a private company. ... - PharmaLive.com (press release),

Antibiotics keep blood bacteria-free  Sep 27, 2005
...as this practice is called. Examples are cephalexin, cefadroxil, cefazolin and azithromycin. Probiotics are friendly bacteria that ... - Contra Costa Times,

Through the golden years: A Grandparent’s Day special  Sep 10, 2005
Essential medicines such as antibiotics (amoxicillin, cefaclor, cephalexin, erythromycin, and co-trimoxazole), as well as those for tuberculosis ... - ABS CBN News,

Highlights of rising and falling US stocks  Sep 15, 2005
Shares of Advancis Pharmaceutical (AVNC) jumped 28% after the company said it agreed to sell the US rights to its Keflex brand of cephalexin to a private ... - Investor's Business Daily (subscription)

Advancis to conduct new Phase III trial  Sep 15, 2005
Advancis bought the Keflex brand of cephalexin, another widely used antibiotic, in July 2004 from pharmaceutical giant Eli Lilly and Company for $11 million ... - Baltimore Business Journal,

Natural Pets  Sep 21, 2005
When he arrived at GRREAT he was receiving Cephalexin twice a day, Prednisone once a day, Benadryl twice a day, and Allergen shots every 3-4 days. ... - Clarke Times Courier,

Cheap branded drugs soon available in Botika ng Bayan  Sep 9, 2005
...in GSK’s Value Health list are the company’s bestsellers, salbutamol (for asthma), antibiotics (amoxicillin, cefaclor, cephalexin, erythromycin, and co ... - INQ7 Interactive, Inc.,

Lupin wins USFDA nod for Cephalexin suspension  Aug 18, 2005
Lupin Ltd on Thursday announced that it has received USFDA approval for its Abbreviated New Drug Application (ANDA) for Cephalexin for Oral Suspension USP 125 ... - India Infoline.com,

Lupin receives USFDA approval for Cephalexin Oral Suspension  Aug 20, 2005
Lupin Ltd (Q, N,C,F)* has received USFDA approval for its Abbreviated New Drug Application (ANDA) for Cephalexin for Oral Suspension USP, 125mg/5 ml and 250mg ... - Myiris.com,

Infections in Patients With Diabetes  Aug 19, 2005
Outpatient antibiotic treatment of cellulitis for GAS and methicillin-susceptible Staphylococcus aureus (MSSA) includes dicloxacillin or cephalexin (Keflex). ... - Medscape (subscription)

Selling sweeps away gains @ 12:37 hrs  Aug 19, 2005
...gain of 2.25% following reports that the company has obtained the approval from US FDA for its Abbrevitated New Drug Application (ANDA) for Cephalexin for Oral ... - Sify,

Orchid to unveil 2 more antibiotics in US  Aug 17, 2005
Orchid has filed 19 ANDAs. So far, the company has received seven approvals that cover three products: Cephalexin, Cefazolin and Ceftriaxone. ... - Sify,

Advancis Pharmaceutical Reports Second Quarter 2005 Results  Aug 5, 2005
...commercialized. Late in the second quarter, Advancis launched Keflex(R) Powder for Oral Suspension (cephalexin, USP) in the United States. ... - Forbes

Beyond boundaries  Jul 11, 2005
Administration. Approved in September was Panixine Disperdose, a dispersible tablet dosage formulation of the antibiotic cephalexin. ... - Med Ad News (subscription)


Other information


Indication
For the treatment of respiratory, skin, soft tissue, urintary tract infections caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A ß-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph

Pharmacology
Cephalexin is a first-generation cephalosporin antibiotic which is effective against most gram-positive bacteria. Cephalexin is used to treat otitis media and respiratory tract infections caused by susceptible staphylococci, Streptococcus pneumoniae, and group A beta-hemolytic streptococci.

Mechanism Of Action
Cephalexin, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cephalexin interferes with an autolysin inhibitor.

Drug Category
Anti-bacterial Agents; Cephalosporins; ATC:J01DB01

Brand Names/Synonyms
Alcephin; Alexin; Alsporin; Biocef; CEX; Carnosporin; Cefa-Iskia; Cefablan; Cefadal; Cefadin; Cefadina; Cefaleksin; Cefalessina [Dcit]; Cefalexin; Cefalexin Sodium; Cefalexina [Inn-Spanish]; Cefalexine [Inn-French]; Cefalexinum [Inn-Latin]; Cefalin; Cefaloto; Cefaseptin; Cefax; Ceforal; Cefovit; Celexin; Cepastar; Cepexin; Cephacillin; Cephalexin; Cephalexin Hydrate; Cephalexin Monohydrate; Cephalexine; Cephalexinum; Cephanasten; Cephaxin; Cephin; Cepol; Ceporex; Ceporex Forte; Ceporexin; Ceporexin-E; Ceporexine; Check; Cophalexin; Durantel; Durantel Ds; Ed a-Ceph; Erocetin; Factagard; Felexin; Fexin; HSDB

Dosage Forms
SUSPENSION; TABLET

Absorption
It is rapidly absorbed after oral administration by the gastrointestinal tract

Interactions
-->Interactions for Cephalexin:

Metformin ó In healthy subjects given single 500 mg doses of cephalexin and metformin, plasma metformin mean cmax and AUC increased by an average of 34% and 24%, respectively, and metformin mean renal clearance decreased by 14%. No information is available about the interaction of cephalexin and metformin following multiple doses of either drug.

Although not observed in this study, adverse effects could potentially arise from co-administration of cephalexin and metformin by inhibition of tubular secretion via organic cationic transporter systems. Accordingly, careful patient monitoring and dose adjustment of metformin is recommended in patients concomitantly taking cephalexin and metformin.

Probenecid ó As with other b -lactams, the renal excretion of cephalexin is inhibited by probenecid.

Drug / Laboratory Test Interactions

As a result of administration of Keflex, a false-positive reaction for glucose in the urine may occur. This has been observed with Benedictís and Fehlingís solutions and also with Clinitest® tablets.

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Chemical IUPAC Name
8-(2-amino-2-phenyl-acetyl)amino-4-methyl-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylicacid

Chemical Formula
C16H17N3O4S

Half Life
1hr

Drug Type
Approved Drug

# Accession No
APRD00250

CAS Registry Number
15686-71-2

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