Celexa: profile and news






This is one problem you can't sleep on ...  Mar 1, 2006
Pretty soon, you're eating Zantac like they were peanuts, and you're getting up two or three times a night to ... well, you know. ... - Jackson Clarion Ledger,

Nobel Prize for Medicine for gastric ulcer breakthrough  Mar 5, 2006
Companies like GlaxoSmithKline and Astra had an annual income of over $8 billion from the sale of ulcer treatments such as “Tagamet� and “Zantac�. ... - World Socialist Web Site,

Ex-ghostbuster seeks to become chart-buster  Mar 5, 2006
Moranis reels off, in rapid succession, the contents of his dream drug cabinet: "I’m on Ritalin, Coumadin, Zantac, Lipitor / Diazepam, Nexium, Prevacid ... - Columbus Dispatch,

FDA seeks to avoid confusing drug names  Mar 2, 2006
...alike drug names. Confusion between such pharmaceutical names as Xanex, Xanax and Zantac may lead to mistakes. In one documented ... - Middle East North Africa Financial Network,

Soy with added soy fiber decreases baby’s spit up  Mar 1, 2006
When basic measures fail to control the problem, two types of medications are generally used – acid-blocking medications such as Pepcid, Zantac, and others ... - Health Sentinel

Geons, Black Holes, and Quantum Foam: A Life in Physics  Mar 3, 2006
...full story. Computer Scientist Sorts Out Confusable Drug Names (March 2, 2006) — Was that Xanex or Xanax? Or maybe Zantac? If ... - Science Daily (press release)

Wockhardt receives US FDA approval for Ranitidine OTC version  Feb 27, 2006
...growth rate of 17 per cent. Ranitidine is the generic version of Pfizer's Zantac 75 tablets. "Wockhardt is already a major player ... - domain-B,

Man sues former employer over drug test  Mar 1, 2006
Cottle maintained that the only extraordinary chemicals in his system were his blood pressure medication and prescribed Zantac, but he says he was ordered off ... - West Virginia Record,

Acid-reducers may hurt preemies  Feb 9, 2006
...stomach acid into the esophagus. Common brands in the class include Tagamet, Pepcid, Zantac and Axid. But doctors at the University ... - Newsday,

Get Heartburn, Indigestion and Ulcer Relief Using DGL  Feb 6, 2006
...suppressing stomach acids. DGL worked just as good as the drugs Zantac or Tagamet that are designed to suppress stomach acid. As more ... - DailyIndia.com,

Too Many Antibiotics Can Cause Other Problems  Feb 14, 2006
In Canada, researchers found the use of over-the-counter medications to suppress stomach acid, such as Pepcid and Zantac, can even double the chances of ... - Click 2 Houston.com,

Preemie Baby Reflux Meds Could Raise Death Risk  Feb 15, 2006
H2 blockers -- which include over-the-counter products such as Axid, Pepcid, Tagamet and Zantac -- inhibit the production of stomach acid. ... - KPHO Phoenix,

Colgate considers buying Listerine  Feb 25, 2006
In addition to Listerine, Pfizer's consumer-health business sells over-the-counter drugs including Sudafed, Rogaine, Visine and Zantac. - New York Daily News,

Wockhardt wins USFDA nod for Ranitidine OTC version  Feb 27, 2006
...with a unit growth rate of 17%. Ranitidine is the generic version of Pfizer Zantac 75 tablets. "Wockhardt is already a major player ... - India Infoline.com,

Common practice of prescribing H2 blockers to treat acid reflux in ...  Feb 24, 2006
The cause of the disorder is unknown. Common H2 blockers are cimetidine (Tagamet), famotidine (Pepcid), ranitidine (Zantac), and nizatidine (Axid). ... - News-Medical.net,

Blockbuster sales boost Glaxo profits  Feb 8, 2006
Losing the patent for best-selling drugs, such as Zantac in GSK's case, means rivals firms can begin to produce cheaper copycat versions of the medicines. ... - Times Online,

Pfizer to Explore Sale or Spinoff of a Division  Feb 7, 2006
No.". Besides Listerine and Benadryl, the unit's other well-known brands include Rogaine, Zantac, Rolaids, Bengay and Lubriderm. ... - New York Times,

Class-action suit filed against Omnicare  Feb 6, 2006
...of substitution of three generic drugs: substituting capsules for tablets of Ranitidine, a generic form of the heartburn drug Zantac; giving tablets instead of ... - Louisville Business First,

H 2 Blockers in Preemies Raise Necrotizing Enterocolitis Risk  Feb 9, 2006
H 2 blockers such as Tagamet (cimetidine), Pepcid (famotidine), Zantac (ranitidine), and Axid (nizatidine) are commonly given to neonates to treat or prevent ... - MedPage Today,

Prescription problems  Feb 13, 2006
...health. Maria says when Cymaiya was just a few weeks old she couldn't keep her baby formula down, so her doctor prescribed Zantac. ... - WHDH-TV,

Super chili bowl battle not for the weak of stomach  Feb 5, 2006
Two of the three judges spill chili on their shirts. One, Watters, buys a box of Zantac at Walgreen’s to protect himself from indigestion. ... - Lincoln Journal Star,

Energized Advocate: Questions for Michael Shames  Feb 17, 2006
The closest he gets to an interview, is "view." The "inter" is really an afterthought.]. A lot of Alka-Seltzer, Pepto-Bismol, Zantac. [He laughs.]. ... - Voice of San Diego,

With the Need to Focus on Rx Pipeline, Pfizer Mulls Divestiture of ...  Feb 13, 2006
...range of categories. Market-leading brands include Listerine, Benadryl, Sudafed, Neosporin, Zantac, and Rogaine. These stalwarts ... - PharmaLive.com (press release),

FOR SUCCESS  Feb 10, 2006
Prilosec. It won out over GlaxoSmithKline's (GSK) Zantac and Tagamet because of improvements such as a one-pill-a-day formula, he says. ... - Investor's Business Daily (subscription)

Take your health to heart -- share a smile instead of a cigarette!  Feb 7, 2006
The most recognizable brands include: Nicorette(*), Nicoderm(*), Benylin(*), Listerine(*), Lubriderm(*), Polysporin(*), Reactine(*) and Zantac(*). ... - Canada NewsWire (press release),

Crunched By The Number  Feb 2, 2006
...foretold the prospect of financial unraveling or worse. One Zantac and five minutes later, however, and I was downshifting again at the driving range. ... - BusinessWeek

Acid Reflux: Is the Medication Worse Than the Condition? FLAVORx ...  09 Feb 2006
Medications to neutralize stomach acid include antacids (Mylanta and Maalox), H2 acid blockers (Tagamet, Zantac and Pepcid) and enzyme-blocking proton-pump ... - Emediawire (press release),

Acid-reducers may hurt preemies  09 Feb 2006
...stomach acid into the esophagus. Common brands in the class include Tagamet, Pepcid, Zantac and Axid. But doctors at the University ... - Newsday,

H 2 Blockers in Preemies Raise Necrotizing Enterocolitis Risk  09 Feb 2006
H 2 blockers such as Tagamet (cimetidine), Pepcid (famotidine), Zantac (ranitidine), and Axid (nizatidine) are commonly given to neonates to treat or prevent ... - MedPage Today,

Common Reflux Treatment Linked to Life Threatening Bowel Infection ...  09 Feb 2006
The cause of the disorder is unknown. Common H2 blockers are cimetidine (Tagamet), famotidine (Pepcid), ranitidine (Zantac), and nizatidine (Axid). ... - Kansas City infoZine,

Pfizer Smacked by NAD Over Zantac 150 Ad Claims  Jan 31, 2006
National Advertising Division (NAD) of the Council of Better Business Bureaus have locked horns over Pfizer's advertising of its heartburn medication Zantac 150 ... - Brandweek Magazine,

Get Heartburn, Indigestion and Ulcer Relief Using DGL  Feb 6, 2006
...suppressing stomach acids. DGL worked just as good as the drugs Zantac or Tagamet that are designed to suppress stomach acid. As more ... - DailyIndia.com,

Blockbuster sales boost Glaxo profits  Feb 8, 2006
Losing the patent for best-selling drugs, such as Zantac in GSK's case, means rivals firms can begin to produce cheaper copycat versions of the medicines. ... - Times Online,

Pfizer to Explore Sale or Spinoff of a Division  Feb 7, 2006
No.". Besides Listerine and Benadryl, the unit's other well-known brands include Rogaine, Zantac, Rolaids, Bengay and Lubriderm. ... - New York Times,

Take your health to heart -- share a smile instead of a cigarette!  Feb 7, 2006
The most recognizable brands include: Nicorette(*), Nicoderm(*), Benylin(*), Listerine(*), Lubriderm(*), Polysporin(*), Reactine(*) and Zantac(*). ... - CNW Telbec (Communiqués de presse),

Class-action suit filed against Omnicare  Feb 6, 2006
...of substitution of three generic drugs: substituting capsules for tablets of Ranitidine, a generic form of the heartburn drug Zantac; giving tablets instead of ... - Louisville Business First,

Super chili bowl battle not for the weak of stomach  Feb 5, 2006
Two of the three judges spill chili on their shirts. One, Watters, buys a box of Zantac at Walgreen’s to protect himself from indigestion. ... - Lincoln Journal Star,

INFECTION PLAYS MAJOR ROLE IN ULCERS  Jan 24, 2006
There are a number of powerful medicines that can turn off acid production. Prilosec, Nexium, Aciphex, Prevacid, Pepcid, Tagamet and Zantac are among them. ... - Charlotte Sun-Herald,

Crunched By The Number  Feb 2, 2006
...foretold the prospect of financial unraveling or worse. One Zantac and five minutes later, however, and I was downshifting again at the driving range. ... - BusinessWeek

Prosecution Rests, Defense Presents First Witnesses In Demeniuk ...  Jan 11, 2006
Demeniuk's attorneys argued that the combination of two anti-depressants Zoloft and Paxil, along with the sedative Zantac and alcohol, contributed to her ... - News4Jax.com,

Omnicare subpoenaed in generic drug probe  Jan 16, 2006
...the investigation. Substituting capsules for tablets of Ranitidine, a generic form of the heartburn drug Zantac. Giving tablets ... - Louisville Business First,

‘Twist’ and out  Jan 27, 2006
Among the most bizarre products were Stag Chili, Dermarest and Zantac—because gay audiences apparently struggle with heartburn, scaly skin and a hankering ... - Southern Voice,

A prescription for future success  Jan 31, 2006
...this task. Prilosec, Claritin, Zantac, Pepcid AC, and Advil successfully changed from prescription to over-the-counter products. ? - Med Ad News (subscription),

Peanut allergy epidemic may be overstated  Jan 29, 2006
Some recent data suggest that avoiding antireflux medications like Zantac, peanut-containing diaper and breast creams, and soy-based formulas may be sensible ... - Boston Globe,

New Treatment for Bleeding Ulcers Reduces Surgery, Death Rates  Jan 25, 2006
...and lansoprazole — to either no drug treatment or alternative acid-suppressing drugs known as H2 receptor antagonists, such as Zantac® and Tagamet®. ... - EndoNurse,

Update 1-Omnicare says gets subpoena from US Attorney  Jan 13, 2006
...the substitution of capsules for tablets of Ranitidine, a generic of GlaxoSmithKline's (GSK.L: Quote, Profile, Research) heartburn drug Zantac; tablets for ... - Reuters

Infection may be related to overuse of antibiotics  Jan 14, 2006
Some studies also have suggested people on powerful heartburn medication such as Nexium and Zantac may be at greater risk for the infection, though questions ... - Lawrence Journal World,

It's Enough to Give Him an Ulcer!  Jan 20, 2006
...with GastroGard.". Other treatment options, according to Andrews, include ranitidine, the human equivalent of Zantac. Daily dosage ... - TheHorse.com,

De-gaying 'Brokeback'  Jan 18, 2006
Among the most bizarre products showcased were Stag Chili, Dermarest and Zantac — because gay audiences apparently struggle with heartburn, scaly skin and ... - Southern Voice,

Students Compete by Counseling Clients  Jan 22, 2006
Davis has been sleeping with his boss, but when he tried to break with her, she threatened to expose Davis' addiction to Zantac. ... - Docket,

SIU doctor aims to teach elder care  Jan 10, 2006
...diagnosed with C-diff. Patients who took less-potent drugs -- including Pepcid and Zantac -- were two times more likely. The problem may ... - Belleville News-Democrat,


Other information


Indication
For the treatment of depression

Pharmacology
Citalopram is one of a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety. The antidepressant, antiobsessive-compulsive, and antibulimic actions of Citalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. In vitro studies show that Citalopram is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Citalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of Citalopram was found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Citalopram does not inhibit monoamine oxidase.

Mechanism Of Action
The antidepressant, antiobsessive-compulsive, and antibulimic actions of Citalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. Citalopram blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT1A autoreceptors. SSRIs bind with significantly less affinity to histamine, acetylcholine, and norepinephrine receptors than tricyclic antidepressant drugs.

Drug Category
Antidepressants; Selective Serotonin Reuptake Inhibitors (SSRIs); ATC:N06AB04; ATC:N06AB10

Brand Names/Synonyms
CHEMBANK1660; Celexa; Cipram; Citalopram; Citalopram Hydrobromide; Citalopram [Ban:Inn]; Citalopramum [Inn-Latin]; Lexapro; Nitalapram

Dosage Forms
Oral solution and tablets

Absorption
80%

Interactions
Central nervous system depressant (CNS) drugs including alcohol, antidepressants, antihistamines, antipsychotics, blood pressure medications (reserpine, methyldopa, beta-blockers), motion sickness medications, muscle relaxants, narcotics, sedatives, sleeping pills and tranquilizers

Chemical IUPAC Name
1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Chemical Formula
C20H21FN2O

Half Life
35 hours

Drug Type
Approved Drug

# Accession No
APRD00147

CAS Registry Number
59729-33-8

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