Celebrex: profile and news
Supplement setbacks: Alternative remedies fail government tests ... 06 Mar 2006
Last month a study revealed negative results for saw palmetto to treat prostate problems; last July, ditto for echinacea and the common cold. ... - Daily News Tribune,
Health Briefs 06 Mar 2006
Glucosamine, echinacea and ginseng - three of the most popular supplements among cosmetic patients - can trigger bleeding, prolong sedation and suppress ... - Winston-Salem Journal,
Stewart Slays, 'Crash' Impact Shocks At Oscars 06 Mar 2006
New York - Little fishes. Big wins. Across Southern California, some snore; others prepare echinacea, Tabasco and egg hangover concoctions. ... - Forbes
Chocolate is good for you if kept in the dark 06 Mar 2006
These products typically are concoctions of "immunity boosters" such as vitamin C, echinacea, zinc and selenium or lesser known herbs such as goji, humic acid ... - Contra Costa Times,
Tell doctor of supplement use before going under the knife 06 Mar 2006
Glucosamine, echinacea and ginseng -- three of the most popular supplements among cosmetic patients -- can trigger bleeding, prolong sedation and suppress ... - Fort Worth Star Telegram,
The cold war rages on: Can Airborne beat the cold? 06 Mar 2006
Airborne's main ingredients are Vitamin C, zinc, echinacea and a concentration of herbal extracts not listed on the box, said Dr. Andy Blalock, president of ... - The Daily Advertiser,
New research bruises reputations of many nutrition supplements Mar 5, 2006
...soon!". Recent government studies have indicated that herbal supplements such as glucosamine, chondroitin, echinacea, St. John's ... - DetNews.com,
Kava kava, echinacea, and ginseng, should they be FDA Approved? Feb 18, 2006
Finally the supplement called Echinacea. Echinacea is a supplement which is used to aid in treating infections caused by over stimulated immune systems. ... - ProgressiveU.org,
Herbal remedies remain popular Mar 3, 2006
A recent study revealed negative results for saw palmetto to treat prostate problems; last July, ditto for echinacea and the common cold. ... - Centre Daily Times,
Alternative medicine common in kids; docs unaware Mar 5, 2006
The sick children were also more likely to use complementary medications (21 per cent versus 4 per cent) -- primarily Echinacea, and herbal and Chinese remedies ... - Sydney Morning Herald,
Many go on taking discredited remedies Feb 27, 2006
Earlier this month, a study yielded negative results for saw palmetto to treat prostate problems; last July, ditto for echinacea and the common cold. ... - Seattle Times,
Consumption might complicate plastic surgeries Mar 5, 2006
The researchers found that the most commonly used herbs and supplements were ephedra (18 percent), chondroitin (18 percent), echinacea (14 percent) and ... - Fort Wayne Journal Gazette,
Research herbal properties, interactions before taking Mar 5, 2006
Or garlic? Echinacea, goldenseal or zinc? Standing in the drugstore you realize you don’t know which brand to buy, or whether it even makes a difference. ... - Fort Wayne Journal Gazette,
Trust the science? Take a look at it first Feb 25, 2006
No release date has been set. Another herbal product that has been widely touted as a cold remedy is echinacea, which is derived from the purple coneflower. ... - Vancouver Sun (subscription),
Inside Out : Guide for making informed choices about lifestyle Feb 27, 2006
Herbal supplements like aged garlic (Kyolic) can enhance health and fight aging. There is more to life than Echinacea, the well-known cold fighter. ... - INQ7.net,
Daisies come in a multitude of colors Feb 23, 2006
...disc florets. Just two of the most obvious daisy-like flowers found at garden centers are Coreopsis and Echinacea. Plant developers ... - Munster Times,
Cutting Through Pharmaceutical Media Spin Mar 2, 2006
...supplement industry was going south. Recent stories show Echinacea, Saw Palmetto, Vitamin E, D and Calcium, St. John's Wort, and now ... - PR Newswire (press release),
Dietary supplements and bird flu – the debate Feb 24, 2006
The products quoted by Professor Ernst included olive leaf extract, garlic, oregano oil, colloidal silver, aloe vera, Echinacea, and green tea. ... - NutraIngredients.com,
Common cold or flu? Mar 4, 2006
Herbs and minerals such as echinacea, maitake, zinc, and vitamin C have also been found to be useful in preventing and speeding up recovery time. ... - Malaysia Star,
What's going on in the gardening world? Mar 4, 2006
Turnbull's lively style. Coneflowers (Echinacea species) bloom for many weeks in summer and attract birds and butterflies. But up ... - Seattle Times,
Despite recent findings, many swear by remedies Feb 27, 2006
Last July, ditto for echinacea and the common cold. ... And critics of the echinacea study say that different doses might have found a benefit in fighting colds. ... - Winston-Salem Journal,
Exploring orchestral life, but not deeply enough Mar 3, 2006
When the orchestra members catalog what's in their stage trunks -- snacks, echinacea, Super Glue, Robert's Rules of Order (''for heated orchestra meetings ... - Boston Globe,
Your Health Mar 3, 2006
Q. What about supplements to prevent cold/flu? A. Sorry. echinacea has been a dismal failure. Cold FX works only if you are Donald $. Cherry. ... - Richmond News,
Learn how to grow giant pumpkins Mar 3, 2006
A mix of coneflowers (Echinacea purpureum), Kansas gayfeather (Liatris spicata) and yarrow (Achillea millefolium) make a great combination. ... - Poughkeepsie Journal,
Red yeast rice capsules: A good statin substitute? Feb 22, 2006
Q. My sister recently visited me with a bad cold and introduced me to echinacea. I ... A. Echinacea has been a disappointment. Although ... - SouthCoastToday.com,
The bottom line: There is no sure route to long life Feb 19, 2006
...the most recent calcium study, I reluctantly added my bottle of calcium pills to the row of discredited supplements on my bathroom shelf: Echinacea doesn't ... - San Jose Mercury News,
Building up natural immunity with vitamins and herbs can help ... Feb 7, 2006
Times provides information about how to build up your flu and cold immunity with special herbs and supplements, including zinc, vitamin C, echinacea and garlic ... - Newstarget.com,
Flu Widespread In DC Area Feb 20, 2006
You can’t get the flu from going out in the cold. Vitamin C, Zinc & Echinacea don’t fight the flu. Antibiotics will do nothing to help your flu bug. ... - W*USA 9,
Students cold remedies vary Feb 8, 2006
In addition to vitamins, sleep and lots of liquids, Boston University students are increasingly turning to Echinacea, Red Bull, spicy foods and ginger to try ... - Daily Free Press (subscription),
Cold remedies: What works, what doesn't, what can't hurt Feb 23, 2006
In spite of ongoing studies, the scientific jury is still out on popular cold remedies such as vitamin C, echinacea and zinc. ... Echinacea. ... - MayoClinic.com
Benefits of calcium start early in life Feb 19, 2006
If you think the herb echinacea will relieve your cold symptoms, you will likely be disappointed. Studies have not shown echinacea ... - Evansville Courier & Press (subscription),
Hybridizers boost palette for blooms Feb 10, 2006
...think about native plants, plants that withstand drought, plants that provide food for birds, one name comes up over and over again: Echinacea, or coneflower. ... - Poughkeepsie Journal,
The use of herbals and plastic surgery Feb 14, 2006
The most popular herbs taken were chondroitin (18 per cent), ephedra (18 per cent), Echinacea (14 per cent), and glucosamine (10 per cent). ... - NutraIngredients-usa.com,
The Dangers Of Herbal Remedies Feb 15, 2006
...it does with any drug. One of the best examples is the way in which Echinacea angustifolia has been misused. The root of this flower ... - Blogcritics.org,
Facing facts at Ground Zero Feb 28, 2006
...the National Institutes of Health suggest there may be little benefit from popular alternative medicines, including glucosamine, chondroitin, echinacea and saw ... - New York Daily News,
Hubbub over non-native/hybrid column Feb 9, 2006
Armitage considers hybridized plants that originated from US natives like Phlox paniculata David and Echinacea purpurea Ruby Star as contributors to our gardens ... - Munster Times,
Personal Health | News and Notes Feb 20, 2006
Besides ephedra, a banned substance taken for weight loss, those used most often by the surgery patients were glucosamine, chondroitin and echinacea. ... - philly.com,
BALM PROTECTS SKIN OF MAMA AND BABY Feb 27, 2006
Chondroitin can contribute to bleeding complications; ephedra (now banned) can cause heart attack or stroke; echinacea can trigger poor wound healing ... - Kansas.com,
Folk remedies widely used by older adults in North Carolina Feb 27, 2006
...vitamins (multivitamins, folic acid and vitamin E), minerals (calcium, magnesium and zinc), herbs (gingko biloba, ginseng and Echinacea), popular manufactured ... - Food Consumer,
Don't let your guard down against the flu Mar 1, 2006
...suppressants. For a more natural remedy, try taking Echinacea, Vitamin C, Goldenseal and Hot Toddies (my personal favorite). These ... - Kykernel.com (subscription),
AHPA starts fifth herbal harvest survey Feb 28, 2006
...in the top-five were slippery elm (100 tons from exclusively wild sources), cascara sagrada (83 tons from only wild sources), and Echinacea angustifolia root ... - NutraIngredients-usa.com,
Think spring Mar 2, 2006
To make this work, Folger used a scratching tool to sketch out a representation of the herb echinacea and then maximized the purple coneflower image with ... - Auburn Citizen,
Science is "Fair game" to Union Grove students Mar 1, 2006
...other was safe. Each experimental group was given one of three herb memory enhancers: B12, Gingko Biloba, and Echinacea. “It was ... - Henry Herald,
Nothing to Sneeze At Feb 27, 2006
Hard to tell. None of its ingredients, including echinacea and vitamins A and C, has been scientifically proven to prevent colds. ... - Forbes
Nature and ‘Supernature’ Mar 1, 2006
We know drugs are addictive, and we moderate. We’re geared-up nightlife warriors, armed with condoms, vitamin C, echinacea, and Chaser Plus hangover pills. ... - LA City Beat,
Herbal Supplements Could Cause Dangerous Side Effects During ... Feb 19, 2006
The most popular herbal supplements were chondroitin (18 percent), ephedra (18 percent), echinacea (14 percent) and glucosamine (10 percent). ... - Medical News Today (press release),
Some Acne information for you Feb 10, 2006
For example, a soap made from Echinacea and other herbal ingredients is an effective antibiotic facial cleanser that helps fight acne and restore clear skin. ... - DailyIndia.com,
Herbs and Cancer Treatment Feb 10, 2006
The herbs that seemed more likely to cause problems were garlic, gingko, Echinacea, soy supplements, ginseng, St. John’s wort, valerian, kava and grape seed. ... - Access North Georgia,
Other information
Indication
For relief and management of osteoarthritis (OA), rheumatoid arthritis (RA), ankylosing spondylitis, acute pain, primary dysmenorrhea and oral adjunct to usual care for patients with familial adenomatous polyposis
Pharmacology
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is classified as a nonsteroidal anti-inflammatory drug (NSAID). Celecoxib is used to treat rheumatoid arthritis, osteoarthritis, and familial adenomatous polyposis (FAP). It is not known if there are any effects of Celecoxib on platelets.
Mechanism Of Action
The mechanism of action of Celecoxib is believed to be due to inhibition of prostaglandin synthesis. Unlike most NSAIDs, which inhibit both types of cyclooxygenases (COX-1 and COX-2), Celecoxib is a noncompetitive inhibitor of cyclooxygenase-2 (COX-2) enzyme. It binds with its polar sulfonamide side chain to a hydrophilic side pocket region close to the active COX-2 binding site. Both COX-1 and COX-2 catalyze the conversion of arachidonic acid to prostaglandin (PG) H2, the precursor of PGs and thromboxane.
Drug Category
Cyclooxygenase Inhibitors; Anti-inflammatory Agents; Nonsteroidal Antiinflammatory Agents (NSAIDs); ATC:L01XX33; ATC:M01AH01
Brand Names/Synonyms
Celebra; Celebrex; Celecoxib; Celocoxib; HSDB 7038; YM 177
Dosage Forms
CELEBREX oral capsules contain 100 mg and 200 mg of celecoxib.
Absorption
When CELEBREX capsules were taken with a high fat meal, peak plasma levels were delayed for about 1 to 2 hours with an increase in total absorption (AUC) of 10% to 20%. Coadministration of CELEBREX with an aluminum-and magnesium-containing antacid resulted in a reduction in plasma celecoxib concentrations with a decrease of 37% in Cmax and 10% in A.C. CELEBREX capsules can be administered without regard to the timing of meals.
Interactions
General: Significant interactions may occur when celecoxib is administered together with drugs that inhibit P450 2C9. Celecoxib metabolism is predominantly mediated via cytochrome P450 2C9 in the liver. Co-administration of celecoxib with drugs that are known to inhibit 2C9 should be done with caution. In vitro studies indicate that celecoxib is not an inhibitor of cytochrome P450 2C9, 2C19 or 3A4. In vitro studies also indicate that celecoxib, although not a substrate, is an inhibitor of cytochrome P450 2D6. Therefore, there is a potential for an in vivo drug interaction with drugs that are metabolized by P450 2D6.
Clinical studies with celecoxib have identified potentially significant interactions with fluconazole and lithium. Experience with nonsteroidal anti-inflammatory drugs (NSAIDs) suggests the potential for interactions with furosemide and ACE inhibitors. The effects celecoxib on the pharmacokinetics and/or pharmacodynamics of glyburide, ketoconazole, methotrexate, phenytoin, tolbutamide, and warfarin have been studied in vivo and clinically important interactions have not been found.
ACE inhibitors: Reports suggest that NSAIDs may diminish the antihypertensive effect of Angiotensin Converting Enzyme (ACE) inhibitors. This interaction should be given consideration in patients taking CELEBREX concomitantly with ACE-inhibitors.
Furosemide: Clinical studies, as well as post marketing observations, have shown that NSAIDs can reduce the natriuretic effect of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis.
Aspirin: CELEBREX can be used with low dose aspirin. However, concomitant administration of aspirin with CELEBREX may result in an increased rate of GI ulceration or other complications, compared to use of CELEBREX alone. Because of its lack of platelet effects, CELEBREX is not a substitute for aspirin for cardiovascular prophylaxis.
Fluconazole: Concomitant administration of fluconazole at 200 mg QD resulted in a two-fold increase in celecoxib plasma concentration. This increase is due to the inhibition of celecoxib metabolism via P450 2C9 by fluconazole (see CLINICAL PHARMACOLOGY - Pharmacokinetics: Metabolism). CELEBREX should be introduced at the lowest recommended dose in patients receiving fluconazole.
Lithium: In a study conducted in healthy subjects, mean steady-state lithium plasma levels increased approximately 17% in subjects receiving lithium 450 mg BID with CELEBREX 200 mg BID as compared to subjects receiving lithium alone. Patients on lithium treatment should be closely monitored when CELEBREX is introduced or withdrawn.
Methotrexate: In an interaction study of rheumatoid arthritis patients taking methotrexate, CELEBREX did not have a significant effect on the pharmacokinetics of methotrexate.
Warfarin: The effect of celecoxib on the anti-coagulant effect of warfarin was studied in a group of healthy subjects receiving daily doses of 2-5 mg of warfarin. In these subjects, celecoxib did not alter the anticoagulant effect of warfarin as determined by prothrombin time. However, caution should be used when administering CELEBREX with warfarin since these patients are at increased risk of bleeding complications.
Chemical IUPAC Name
4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
Chemical Formula
C17H14F3N3O2S
Half Life
~11 hours
Drug Type
Approved Drug
# Accession No
APRD00373
CAS Registry Number
169590-42-5