Cefzil: profile and news

First-Time Generic Approvals: Zithromax, Cefzil, Zonegran Jan 27, 2006
FDA approved first-time generic formulations for cefprozil 125-mg/5-mL and 250-mg/5-mL suspension (made by Teva Pharmaceuticals USA; brand name Cefzil, made by ... - Medscape (subscription)

Bristol-Myers Squibb Company Reports Financial Results for the ... Jan 25, 2006
...the 2005 levels for products which have lost or will lose exclusivity protection in 2004, 2005 or 2006, primarily PRAVACHOL(R), TAXOL(R) and CEFZIL(R). The ... - PR Newswire (press release),

for Oral Suspension Jan 18, 2006
Cefprozil is the generic version of Bristol-Myers Squibb Company's broad-spectrum cephalosporin antibiotic Cefzil®. Annual US sales ... - Pharmaceutical Processing,

UPDATE 2-Bristol-Myers sees 2006 profit falling 13-20 pct Jan 25, 2006
Sales of cancer drug Taxol declined 29 percent to $181 million as generic rivals became available in Europe, while sales of antibiotic Cefzil fell 16 percent ... - Reuters

Bristol-Myers Catches a Cold Jan 25, 2006
...the company's own estimation, it will lose more than another $1 billion in sales in 2006 to generic competition for drugs such as Pravachol, Taxol, and Cefzil. ... - Motley Fool

Bristol earnings up, but issues warning Jan 25, 2006
Sales of two other compounds, cancer drug Taxol and antibiotic Cefzil, also were down by double digits because of generic competition. ... - Newark Star Ledger,

FDA approves Teva antibiotic Cefprozil 11 Dec 2005
Tablets and Cefprozil for Oral Suspension are the AB-rated generic equivalents of Bristol-Myers Squibb's broad-spectrum cephalosporin antibiotic Cefzil. ... - Globes,

Dongkuk Steel, Hon Hai, Hyundai: Asia Ex-Japan Equity Preview Dec 9, 2005
Lupin Ltd. (LPC IN): The Indian drugmaker received approval to sell a generic version of Bristol-Myers Squibb Co.'s antibiotic Cefzil in the US Lupin won ... - Bloomberg

Book Review - The PDR Family Guide to Prescription Drugs Sep 17, 2005
These include Arthritis, Antibiotics for ulcers, Burcitis, Cefzil, Gigantism, Heart Valve Replacement, Pancreatic Cancer, Remeron and Vomiting as a symptom of ... - Bella Online

Free Health Stuff for Your Kids Aug 19, 2005
Antibiotics which are usually in good supply in most Pediatrician's offices include Augmentin ES, Cefzil, Omnicef, Zithromax, Duricef, Ceftin, Lorabid and many ... - pediatrics.about.com

Bristol-Myers Quarterly Profit Increases, Helped by Plavix Drug Jul 28, 2005
Bristol-Myers reiterated in April that revenue this year will decline as the company loses sales from the Glucovance diabetes medicine, Cefzil antibiotic and ... - Bloomberg <**results**>

Free Health Stuff for Your Kids Jun 21, 2005
Antibiotics which are usually in good supply in most Pediatrician's offices include Augmentin ES, Cefzil, Omnicef, Zithromax, Duricef, Ceftin, Lorabid and many ... - pediatrics.about.com

Bristol-Myers Squibb Reports First Quarter 2005 Results in Line ... Apr 28, 2005
...from the 2004 levels for products which have lost or will lose exclusivity protection in 2003, 2004 or 2005, primarily GLUCOVANCE(R), CEFZIL(R), PARAPLATIN(R ... - PR Newswire

Bristol-Myers Squibb Reports First Quarter 2005 Results in Line ... 28 Apr 2005
...from the 2004 levels for products which have lost or will lose exclusivity protection in 2003, 2004 or 2005, primarily GLUCOVANCE(R), CEFZIL(R), PARAPLATIN(R ... - PR Newswire

Other information

Indication
For the treatment of the following infections (respiratory, skin, soft tissue, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph

Pharmacology
Cefprozil, a semisynthetic, second-generation cephalosporin, is used to treat otitis media, soft-tissue infections, and respiratory tract infections.

Mechanism Of Action
Cefprozil, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefprozil interferes with an autolysin inhibitor.

Drug Category
Anti-bacterial Agents; Cephalosporins; ATC:J01DC10

Brand Names/Synonyms
Arzimol; Brisoral; Cefprozil anhydrous; Cefprozilo [INN-Spanish]; Cefprozilum [INN-Latin]; Cefzil; Cronocef; Procef; Serozil

Dosage Forms
Cefzil tablets contain cefprozil equivalent to 250 mg or 500 mg of anhydrous cefprozil.

Absorption
Oral_~95%

Interactions
Nephrotoxicity has been reported following concomitant administration of aminoglycoside antibiotics and cephalosporin antibiotics. Concomitant administration of probenecid doubled the AUC for cefprozil. The bioavailability of the capsule formulation of cefprozil was not affected when administered 5 minutes following an antacid.

Chemical IUPAC Name
8-[2-amino-2-(4-hydroxyphenyl)-acetyl]amino-7-oxo-4-prop-1-enyl-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylicacid

Chemical Formula
C18H19N3O5S

Half Life
1.3 hours

Drug Type
Approved Drug

# Accession No
APRD00461

CAS Registry Number
92665-29-7