Ceftin: profile and news






Mom discovers prescription error at CVS  Mar 4, 2006
She said the pharmacist said, ''Oh God, hold on a minute.''. Instead of the prescribed antibiotic Ceftin, Tor had received another antibiotic, Cephalexin. ... - Daily Hampshire Gazette (subscription),

Ranbaxy out to buy German, Romanian firms  Jan 17, 2006
...won a patent challenge since August 2001 when it received approval from a United States’ court for its version of GlaxoSmithKline Plc’s Ceftin antibiotic. - Hindustan Times,

Accupril gives another blow to Ranbaxy  Nov 23, 2005
...seller Nexium. After winning permission to sell a GlaxoSmithKline's Ceftin in 2002, Ranbaxy hasn't won a patent case since then. It ... - Financial Express,

Lyme disease symptoms still affect local resident  Sep 25, 2005
2004. She has been on the protocol of more than 30 pills a day since May. "I'm currently on 1,000 mg of Ceftin and 200 mg. of minocycline ... - Keyser Mineral Daily News Tribune,

Finding best generic drug  Sep 19, 2005
Their prices are about 50 percent of the name-brand Ceftin. But a Wal-Mart in Forest Park offers the generic for 81 percent less than the brand-name drug. ... - Chicago Sun-Times,

Ranbaxy guns for Pfizer's $12-b cholesterol drug — Generic cos ...  Sep 12, 2005
...litigations, Ranbaxy had also fought a long legal battle for the US market to launch the generic cefuroxime axetil sold under the brandname Ceftin by the ... - Hindu Business Line,

Free Health Stuff for Your Kids  Aug 19, 2005
Antibiotics which are usually in good supply in most Pediatrician's offices include Augmentin ES, Cefzil, Omnicef, Zithromax, Duricef, Ceftin, Lorabid and many ... - pediatrics.about.com

Wockhardt gets USFDA nod for cefuroxime axetil  Aug 2, 2005
Cefuroxime axetil, the generic version of Glaxo SmithKline's Ceftin, will be the sixth product to be marketed under the company's banner in the US. ... - Business Standard

Lipitor generic possible  Jul 25, 2005
In 2002, during a legal struggle with GlaxoSmithKline over a generic version of the antibiotic Ceftin, Deshmukh advised Ranbaxy to take its generic version to ... - MSNBC <**results**>

Steroid Nasal Sprays Seem to Speed Sinusitis Recovery  Jun 30, 2005
...symptoms. GlaxoSmithKline, maker of fluticasone (Flonase®) and cefuroxime (Ceftin®), funded and supplied the medication for the study. - eMaxHealth.com

Free Health Stuff for Your Kids  Jun 21, 2005
Antibiotics which are usually in good supply in most Pediatrician's offices include Augmentin ES, Cefzil, Omnicef, Zithromax, Duricef, Ceftin, Lorabid and many ... - pediatrics.about.com

Free Health Stuff for Your Kids  Jun 21, 2005
Antibiotics which are usually in good supply in most Pediatrician's offices include Augmentin ES, Cefzil, Omnicef, Zithromax, Duricef, Ceftin, Lorabid and many ... - pediatrics.about.com

Pharma cos facing blues as US sales falter  May 31, 2005
Ranbaxy's profit soared after the New Delhi-based company won permission to sell its version of Ceftin, a GlaxoSmithKline Plc antibiotic, in the US beginning ... - Financial Express,

Around Asia's Markets: US snags hurt drug producers in India  Jun 1, 2005
Ranbaxy's profit soared after the New Delhi-based company won permission to sell its version of Ceftin, a GlaxoSmithKline antibiotic, in the United States ... - International Herald Tribune,

Pharma: Dosages may need tweaking  May 15, 2005
Ranbaxy, too, enjoyed an extended run with Ceftin (a version of GlaxoSmithKline's Augmentin), which pulled in revenues in excess of $100 million (about Rs 450 ... - Sify

Ranbaxy's Profit Falls as Sales Falter in Key Markets (Update2)  Apr 28, 2005
Ranbaxy, which sold a copy of GlaxoSmithKline Plc's antibiotic Ceftin for more than a year in the US starting March 2002 without competition, failed to repeat ... - Bloomberg

Ranbaxy's Profit Falls as Sales Falter in Key Markets (Update2)  28 Apr 2005
Ranbaxy, which sold a copy of GlaxoSmithKline Plc's antibiotic Ceftin for more than a year in the US starting March 2002 without competition, failed to repeat ... - Bloomberg

Ranbaxy to appeal against injunction  Mar 30, 2005
...is not ready. Interestingly, Ranbaxy has been conservative in launching drugs in the US like Augmentin and Ceftin. Quinapril was ... - Moneycontrol.com,

PDI Reports Year End and Fourth Quarter 2004 Financial Results  Mar 9, 2005
Adjustments for 2004 and 2003 Ceftin Product Returns and 2004 Xylos Write Downs In the fourth quarter of 2003, the Company increased its reserve for Ceftin ... - PR Newswire (press release)

PDI Reports Year End and Fourth Quarter 2004 Financial Results  Mar 9, 2005
In the fourth quarter of 2003, the Company increased its reserve for Ceftin product returns by $12.0 million to cover the cost of estimated Ceftin product ... - Yahoo News (press release)


Other information


Indication
For the treatment of the following infections (respiratory, skin, soft tissue, urinary tract infections, ear, nose, throat infectsion) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A ß-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph. Also used to treat acute bacterial bronchitis in patients with COPD

Pharmacology
Cefuroxime, a second-generation cephalosporin, is used to treat severe upper and lower respiratory tract infections, skin infections, otitis media, and surgical prophylaxis.

Mechanism Of Action
Cefuroxime, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefuroxime interferes with an autolysin inhibitor.

Drug Category
Anti-bacterial Agents; Cephalosporins; ATC:J01DC02

Brand Names/Synonyms
Ancef; Biofuroksym; Ceclor; Ceclor Cd; Cedax; Cefditoren; Cefizox; Cefotan; Ceftin; Ceftizoxime Sodium; Cefurax; Cefuril; Cefuroxim; Cefuroxime; Cefuroxime Axetil; Cefuroxime Free Acid; Cefuroxime Sodium; Cefuroxime Sodium Salt; Cefuroxime [Usan:Ban:Inn]; Cefuroxime and Dextrose in Duplex Container; Cefuroximo [Inn-Spanish]; Cefuroximum [Inn-Latin]; Cefzil; Cephuroxime; Ceptaz; Duricef; Elobact; Fortaz; Keflex; Keftab; Kefurox; Kefurox in Plastic Container; Kerurox; Mandol; Maxipime; Mefoxin; Monocid; Omnicef; Oraxim; Rocephin; Sharox; Tazicef; Vantin; Velosef; Zinacef; Zinacef Danmark; Zinacef in Plastic Container; Zinat; Zinnat

Dosage Forms
POWDER; POWDER FOR SOLUTION; TABLET

Absorption
Well absorbed from the GI tract (bioavailability is 37-52%)

Interactions
-->Interactions for Cefuroxime:

Drug/Laboratory Test Interactions: A false-positive reaction for glucose in the urine may occur with copper reduction tests (Benedictís or Fehlingís solution or with ClinitestÒ tablets) but not with enzyme-based tests for glycosuria. As a false-negative result may occur in the ferricyanide test, it is recommended that either the glucose oxidase or hexokinase method be used to determine blood plasma glucose levels in patients receiving cefuroxime.

Cefuroxime does not interfere with the assay of serum and urine creatinine by the alkaline picrate method.



Chemical IUPAC Name
4-(carbamoyloxymethyl)-8-[2-(2-furyl)-2-methoxyimino-acetyl]amino-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylic acid

Chemical Formula
C16H16N4O8S

Half Life
~80 minutes

Drug Type
Approved Drug

# Accession No
APRD00285

CAS Registry Number
55268-75-2

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