Cefixime: profile and news

Steep fall in prices of medicines Feb 19, 2006
290.75. The chemists are attributing this drop in prices to the drop in the cost of a basic salt, used in the manufacture, 'Cefixime'. ... - TMCnet

An open letter to the pharmaceutical industry Jan 29, 2006
...money. Aslo, can someone please explain to me why cefixime is no longer on the market? ... fine. Can't someone make cefixime for us? ... - Staunton News Leader,

Prescribing medicine in Ramzan Oct 20, 2005
On the other hand antibiotics like clarithromycin, ciprofloxacin, cefuroxime, cefixime, co-trimoxazole, doxycycline can be conveniently taken twice daily ... - Independent-Bangladesh,

Lupin gets USFDA nod Aug 18, 2005
Earlier it had received approvals for Ceftriaxone for injection, Cefotaxime for injection, Cefuroxime Axctil tablets and Cefixime tablets and oral suspension. - Sify,

Treating Partners Immediately Reduces Recurrence of STDs Jul 31, 2005
The treatment medication was consistent with standard guidelines (ie, 400 mg of cefixime [Suprax] plus 1 g of azithromycin [Zithromax] for patients with ... - RedNova.com

US tonic helps Lupin dream big Jul 8, 2005
Pharmaceuticals Inc (LPI), had entered into a promotional tie-up with Cornerstone BioPharma Inc for the US market for its Suprax (cefixime) anti-infective drug ... - Calcutta Telegraph <**results**>

Lupin in marketing pact with US firms May 29, 2005
...subsidiary, Lupin Pharmaceuticals Inc (LPI), has an alliance with Cornerstone BioPharma as a promotion partner in the US for its Suprax (cefixime) antiinfective ... - Business Standard,

Lupin strikes outlicencing deal with Cornerstone May 13, 2005
Lupin had, earlier in January 2005, entered into an alliance with Cornerstone through its wholly-owned subsidiary to co-promote Suprax (cefixime) anti-infective ... - Express Pharma Pulse

Gay men continue to see gonorrhoea rises May 5, 2005
As a result the newer antibiotics ceftriaxone (which has to be injected) and cefixime took over as the most frequently used treatment for the first time in 2003 ... - Gay.com UK,

Lupin looks to beef up US presence, eyes $100m buy Mar 3, 2005
Last year, Lupin launched its first product Suprax (cefixime) in the US through its wholly-owned subsidiary, Lupin Pharmaceuticals. ... - Economic Times,

Lupin's unsexy, but great, success story! Mar 3, 2005
Lupin is relatively new to the US, where it sells the generic antibiotics and the pediatric antibiotic cefixime (sold under the name Suprax), so it must ... - Rediff,

Immediate Access To Antibiotics Stems Spread Of Sexually ... Mar 4, 2005
Packets contained the standard treatment for each STD, which is one tablet each of cefixime (400 milligrams) for gonorrhea and azithromycin (1 gram) for ... - Science Daily (press release)

Other information

Indication
For the treatment of the following infections (UTI, respiratory, ENT) caused by; E.coli, P.mirabilis, H.influenzae (beta-lactamase positive and negative strains), M.catarrhalis, (most of which are beta-lactamase positive), S. pyogenes, S.pneumoniae, N.gon

Pharmacology
Cefixime, an antibiotic, a third-generation cephalosporin like ceftriaxone and cefotaxime, is used in the treatment of otitis media, and respiratory tract and urinary tract infections. The antibacterial effect results from inhibition of mucopeptide synthesis in the bacterial cell wall

Mechanism Of Action
Like all beta-lactam antibiotics, cefixime binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefixime interferes with an autolysin inhibitor.

Drug Category
Anti-bacterial Agents; Cephalosporins; ATC:J01DD08

Brand Names/Synonyms
CFIX; Cefixim; Cefixima [Spanish]; Cefixime; Cefixime Anhydrous; Cefixime [Usan:Ban:Inn:Jan]; Cefiximum [Latin]; Cefixoral; Cefspan; Cephoral; FK 027; Oroken; Suprax; Unixime

Dosage Forms
Oral Suspension; Tablet; POWDER FOR SOLUTION; POWDER FOR SUSPENSION

Absorption
Orally 40-50%

Interactions
-->Interactions for Cefixime:

Carbamazepine: Elevated carbamazepine levels have been reported in postmarketing experience when SUPRAX is administered concomitantly. Drug monitoring may be of assistance in detecting alterations in carbamazepine plasma concentrations.

Warfarin and Anticoagulants: Increased prothrombin time, with or without clinical bleeding, has been reported when cefixime is administered concomitantly.

Drug/Laboratory Test Interactions

A false-positive reaction for ketones in the urine may occur with tests using nitroprusside but not with those using nitroferricyanide.

The administration of SUPRAX may result in a false-positive reaction for glucose in the urine using Clinitest^Ò**, Benedictís solution, or Fehlingís solution. It is recommended that glucose tests based on enzymatic glucose oxidase reactions (such as Clinistix^®** or Tes-Tape^Ò**) be used. A false-positive direct Coombs test has been reported during treatment with other cephalosporin antibiotics; therefore, it should be recognized that a positive Coombs test may be due to the drug.

Chemical IUPAC Name
8-[2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethoxyimino)acetyl]amino-4-ethenyl-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylic acid

Chemical Formula
C16H15N5O7S2

Half Life
3-4 hours

Drug Type
Approved Drug

# Accession No
APRD00583

CAS Registry Number
79350-37-1