Cefadroxil: profile and news

Antibiotics keep blood bacteria-free Sep 27, 2005
...as this practice is called. Examples are cephalexin, cefadroxil, cefazolin and azithromycin. Probiotics are friendly bacteria that ... - Contra Costa Times,

Other information

Indication
For the treatment of the following infections (skin, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staphylococci and Staphylococcu

Pharmacology
Cefadroxil, a first-generation cephalosporin antibiotic, is used to treat urinary tract infections, skin and skin structure infections, pharyngitis, and tonsillitis.

Mechanism Of Action
Like all beta-lactam antibiotics, cefadroxil binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefadroxil interferes with an autolysin inhibitor.

Drug Category
Anti-bacterial Agents; Cephalosporins; ATC:J01DB05

Brand Names/Synonyms
Baxan; Bidocef; CDX; Cefa-Drops; Cefadroxil; Cefadroxil Micronised Powder; Cefadroxil Monohydrate; Cefamox; Ceforal; Cefradroxil; Cephos; Duracef; Duricef; Kefroxil; Oracefal; Sedral; Sumacef; Ultracef

Dosage Forms
Cefadroxil comes as a capsule, tablet, and liquid to take by mouth

Absorption
Cefadroxil is well absorbed on oral administration; food does not interfere with the absorption

Interactions
-->Interactions for Cefadroxil:

Drug/Laboratory Test Interactions

Positive direct Coombsí tests have been reported during treatment with the cephalosporin antibiotics. In hematologic studies or in transfusion cross-matching procedures when anti-globulin tests are performed on the minor side or in Coombsí testing of newborns whose mothers have received cephalosporin antibiotics before parturition, it should be recognized that a positive Coombsí test may be due to the drug.

Chemical IUPAC Name
8-[2-amino-2-(4-hydroxyphenyl)-acetyl]amino-4-methyl-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylicacid

Chemical Formula
C16H17N3O5S

Half Life
1.5 h

Drug Type
Approved Drug

# Accession No
APRD00196

CAS Registry Number
66592-87-8