Ceclor: profile and news

Second mix-up at pharmacy Jan 31, 2006
...try another antibiotic. He prescribed cefaclor, dispensed as ceclor, and City Health Pharmacy filled the prescription. After three ... - Manawatu Standard,

Lilly finds low-cost labor in China Aug 14, 2005
...offices. A Lilly factory in Suzhou manufactures Ceclor and repackages Prozac, Humulin, Humalog and Evista for the China market. ... - Indianapolis Star,

Drugmaker wins in stock fraud lawsuit Apr 20, 2005
Dura Pharmaceuticals – the then-San Diego-based maker of allergy and asthma prescription drugs – made statements promoting "strong" sales of Ceclor CD, a ... - San Diego Union Tribune

Other information

Indication
For the treatment of the following infections (respiratory, skin, soft tissue, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A ß-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph

Pharmacology
Cefaclor, a second generation cephalosporin with a spectrum resembling first-generation cephalosporins, is used to treat otitis media, sinusitis, and upper respiratory tract infection caused by ampicillin or amoxicillin-resistant H. influenzae. Alsos used to treat ear, lung, skin, throat, and urinary tract infections.

Mechanism Of Action
Cefaclor, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins. It is possible that cefaclor interferes with an autolysin inhibitor.

Drug Category
Anti-bacterial Agents; Cephalosporins; ATC:J01DC04

Brand Names/Synonyms
Alenfral; Alfacet; Alfatil; CCL; Ceclor; Ceclor Cd; Cefaclor; Cefaclor Anhydrous; Cefaclorum; Cefaclorum [Inn-Latin]; Cephaclor; Distaclor; Kefral; Kefral, Raniclor; Panacef; Panoral; Raniclor; S 6472

Dosage Forms
CAPSULE; POWDER; POWDER FOR SOLUTION; POWDER FOR SUSPENSION; SUSPENSION

Absorption
Well absorbed after oral administration, independent of food intake

Interactions
Interactions for Cefaclor:

No information provided.

Chemical IUPAC Name
8-(2-amino-2-phenyl-acetyl)amino-4-chloro-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylicacid

Chemical Formula
C15H14ClN3O4S

Half Life
0.6-0.9 hour

Drug Type
Approved Drug

# Accession No
APRD00243

CAS Registry Number
53994-73-3