Catapres: profile and news

Treating ADD With Medication 06 Mar 2006
...medicine sometimes used to treat ADD include atomoxetine, known as Stratera; buproprion, known as Wellbutrin; clonidine, known as Catapres; imipramine, known ... - DailyIndia.com,

Monoaminergic Treatment of Schizophrenia Feb 27, 2006
1997). These deficits are improved by clonidine (Catapres), an α 2 adrenergic receptor agonist (Arnsten and Goldman-Rakic, 1985). ... - Psychiatric Times,

Sleeping Through Detox Poses Hazards Jan 12, 2006
A randomized trial comparing anesthesia-, buprenorphine- (Subutex) and clonidine- (Catapres) assisted heroin detoxification found similarity in withdrawal ... - Psychiatric Times,

Some fiber supplements cause gas Dec 2, 2005
Dear Dr. Gott: Why aren't more medicines given by patch? I've taken Catapres by tablet and patch, and there is no comparison. I ... - Monterey County Herald,

SUSAN TOMPOR: Picking the right drug plan requires research Nov 16, 2005
Drugs: He has four prescriptions: Hyzar, which treats high blood pressure; Catapres, an anti-hypertension medication; Monopril, a high blood pressure medication ... - Detroit Free Press,

Film details Redonto boy's struggle with Tourette's Nov 12, 2005
Today Seth is prescribed a Catapres patch to suppress his tics and Paxil to help with his obsessive-compulsive disorder, another symptom of Tourette's syndrome ... - Daily Breeze,

Behavioral and Pharmacologic Treatment of Aggression in Children ... Oct 3, 2005
Clonidine (Catapres), an α2-adrenergic agonist, was efficacious in two short-term, placebo-controlled trials, but its long-term efficacy has been questioned ... - Psychiatric Times,

URL/Mutual Tracking to Achieve Another Record Year in Sales ... Sep 12, 2005
Other recent URL/Mutual launches include Clonidine 0.1mg, 0.2mg, and 0.3mg Tablets (AB-rated to Catapres), Doxycycline Hyclate 20mg Tablets (AB-rated to ... - PR Newswire (press release),

ADHD: What now? Aug 4, 2005
In the remaining cases where Ritalin is ineffective or where side-effects become problematic, alternative treatments such as Tofranil, Catapres, Aurorix or ... - Health24.com

Russia’s Biggest Spammer Murdered Jul 26, 2005
...told the Kommersant newspaper. Clonidine is a soporific drug, and is also known under the brand name Catapres. Police detained one ... - WebProNews

Par loses ground in 2nd quarter Jul 29, 2005
One highly anticipated product, a version of the Catapres patch for hypertension, has been under review at the Food and Drug Administration for four years, and ... - NorthJersey.com

Tourette Syndrome Jul 19, 2005
The medications most commonly used to treat Tourette's syndrome are haloperidol (Haldol), pimozide (Orap), fluphenazine (Prolixin), and clonidine (Catapres). ... - rarediseases.about.com <**results**>

German Remedies to market Bio Sidus’ oncology product in India Jun 24, 2005
From this unit the company markets products like Acetyle salicylic acid, Catapres (Boehringer Ingelheim), Ildamen (Asta Medica), Nivant for heart disorders and ... - Express Pharma Pulse

Psychopharmacology of Autism Spectrum Disorders Jun 20, 2005
Clonidine (Catapres) has been shown to reduce irritability, hyperactivity and impulsivity in two double-blind trials (Fankhauser et al., 1992; Jaselskis et al ... - Psychiatric Times

Multi-Modal Integrated Treatment for Youth With Bipolar Disorder Jun 20, 2005
In moderate to severe presentations, a combination of mood stabilizer and SGA is used (Table 1 and Table 2). Clonidine (Catapres) can be used to subdue rage ... - Psychiatric Times,

Par diversifying into brand-new turf Apr 28, 2005
...painkiller Ultracet. Wall Street |is also eagerly awaiting the approval of a version of the Catapres patch for hypertension. The ... - NorthJersey.com,

Par diversifying into brand-new turf 28 Apr 2005
...painkiller Ultracet. Wall Street |is also eagerly awaiting the approval of a version of the Catapres patch for hypertension. The ... - NorthJersey.com,

Management of Hypertension in Older Persons Feb 21, 2005
...hypertension. Central alpha agonists include clonidine (Catapres), guanfacine (Tenex), methyldopa (Aldomet), and reserpine (Serpasil). ... - RedNova.com,

Other information

Indication
For the treatment of hypertension and maybe used in prophylaxis of migraine or recurrent vascular headache; Menopausal flushing

Pharmacology
Clonidine is an antihypertensive agent and an epidural agent for refractory cancer pain. Similar to guanabenz in mechanism of action, clonidine is used in the treatment of hypertension, opiate and nicotine withdrawal, vascular headaches, diabetic diarrhea, glaucoma, ulcerative colitis, Gilles de la Tourette's syndrome, menopause symptoms, severe pain in cancer patients refractory to opiate agonists, and neuropathic pain and in the diagnosis of pheochromocytoma.

Mechanism Of Action
Clonidine acts as an agonist at presynaptic alpha(2)-receptors in the nucleus tractus solitarius of the medulla oblongata. Stimulation of these receptors results in the supression of efferent sympathetic pathways and the subsequent decrease in blood pressure and vascular tone in the heart, kidneys, and peripheral vasculature. Clonidine is also a partial agonist at presynaptic alpha(2)-adrenergic receptors of peripheral nerves in vascular smooth muscle.

Drug Category
Sympatholytics; Antihypertensive Agents; Analgesics; Central Alpha-Agonists; ATC:C02AC01; ATC:N02CX02; ATC:S01EA03; ATC:S01EA04

Brand Names/Synonyms
Adesipress; CCRIS 7787; Catapres; Catapres-Tts; Catapresan; Catapressan; Catarpres; Catarpresan; Chlornidinum; Clonidin; Clonidine; Clonidine Hcl; Clonidinhydrochlorid; Clonidinum [Inn-Latin]; Clonistada; Dixarit; Duraclon; Duraclont; HSDB 3040; Iopidine; Ipotensium; Isoglaucon; M 5041T; M-5041T; ST 155BS; Tenso-Timelets

Dosage Forms
tablets, patches

Absorption
40-60%

Interactions
-->Interactions for Clonidine:

Tablet

If a patient receiving clonidine hydrochloride is also taking tricyclic antidepressants, the effect of clonidine may be reduced, thus necessitating an increase in dosage. Clonidine hydrochloride may enhance the CNS-depressive effects of alcohol, barbiturates or other sedatives. Amitriptyline in combination with clonidine enhances the manifestation of corneal lesions in rats

Epidural Injection

Clonidine may potentiate the CNS-depressive effect of alcohol, barbiturates or other sedating drugs. Narcotic analgesics may potentiate the hypotensive effects of clonidine. Tricyclic antidepressants may antagonize the hypotensive effects of clonidine. The effects of tricyclic antidepressants on clonidine's analgesic actions are not known.

Beta blockers may exacerbate the hypertensive response seen with clonidine withdrawl. Also, due to the potential for additive effects such as bradycardia and AV block, caution is warranted in patients receiving clonidine with agents known to affect sinus node function or AV nodal conduction (e.g., digitalis, calcium channel blockers, and beta-blockers.)

There is one reported case of a patient with acute delirium associated with the simultaneous use of fluphenazine and oral clonidine. Symptoms resolved when clonidine was withdrawn and recurred when the patient was rechallenged with clonidine.

Epidural clonidine may prolong the duration of pharmacologic effects of epidural local anesthetics, including both sensory and motor blockade.

Chemical IUPAC Name
N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine

Chemical Formula
C9H9Cl2N3

Half Life
12-16 hours

Drug Type
Approved Drug

# Accession No
APRD00174

CAS Registry Number
4205-90-7