Carboplatin: profile and news






Antidepressants Linked to Modest Risk of Non-Fatal Thoughts in ...  06 Mar 2006
Psychiatry. The one independent study was a multicenter trial that evaluated a single drug, Prozac (fluoxetine), the researchers reported. ... - MedPage Today,

Trimipramine for Refractory Panic Attacks  Mar 2, 2006
...no avail (either were ineffective or were discontinued because of side effects) included amitriptyline, bupropion, amoxapine, fluoxetine, sertraline, citalopram ... - Am J Psychiatry (subscription)

QTc Prolongation and Torsades de Pointes in an Elderly Woman ...  Feb 14, 2006
We describe an 83-year-old woman who experienced multiple episodes of torsades de pointes, probably because she was taking fluoxetine. ... - Am J Psychiatry (subscription)

Brain white-matter hyperintensities and treatment outcome in major ...  Feb 8, 2006
...mean age 40.7, sd=10.2), recruited through advertisements and clinical referrals for a clinical trial beginning with open-label fluoxetine treatment (Fava et al ... - British Journal of Psychiatry (subscription),

Par Pharmaceutical Reports Sales and Earnings for 2005  Feb 28, 2006
HCl tablets, the generic version of the antidepressant Paxil(R), megestrol acetate oral suspension, the generic form of Megace, and fluoxetine, the generic ... - MSN Money

Health Canada Warning: Brazilian Diet Pills Contain Active ...  Feb 22, 2006
...found that Emagrece Sim, also known as the Brazilian Diet Pill, and Herbathin, contain the prescription-only pharmaceutical compound fluoxetine HCl (the active ... - Halifax Live,

Health Canada Issues Warning that Two Weight-Loss Products Contain ...  Feb 23, 2006
Recently, the FDA found that Emagrece Sim, also known as the Brazilian Diet Pill, and Herbathin, contain the prescription-only compound fluoxetine HCl (the ... - Newsinferno.com,

Antidepressants: Are they safe during pregnancy?  Feb 22, 2006
Although certain antidepressants have not been linked with an increased risk of birth defects or impaired development — including fluoxetine (Prozac, Sarafem ... - MayoClinic.com

Hepatitis C Treatment for People With Severe Mental Illness  Feb 28, 2006
Med J Austral 2000; 173:359–361[Medline]. Levenson JL, Fallon HJ: Fluoxetine treatment of depression caused by interferon-alpha (comment). ... - Psychosomatics (subscription)

Depression - Symptoms, Causes and Treatment options  Feb 15, 2006
Examples of this medication type are: Fluoxetine (Prozac), fluvoxamine (Luvox), paroxetine (Paxil), escitalopram (Lexapro, Celexa), sentraline (zoloft). ... - DailyIndia.com,

Treatment-Resistant Bipolar Depression: A STEP-BD Equipoise ...  Feb 9, 2006
Other options include combining mood stabilizers (20), switching to the combination of olanzapine and fluoxetine (21), switching to quetiapine (22), or adding ... - Am J Psychiatry (subscription)

Popular Antidepressants Boost Brain Growth, Hopkins Scientists ...  Feb 6, 2006
In the Johns Hopkins study, Koliatsos and his team gave either the selective serotonin reuptake inhibitor fluoxetine (Prozac), the selective serotonin reuptake ... - Johns Hopkins Gazette,

Evelyn Pringle: Poisoning In the Womb – SSRIs  Feb 19, 2006
LM, Felix RJ, Jones KL. Birth outcomes in pregnant women taking fluoxetine. N Engl J Med.1996; 335 :1010 –1015. A new risk was ... - Scoop.co.nz (press release),

Women and Depression  Feb 23, 2006
...them find medications that have similar action to estrogen, but without the risks. Two potential candidates are soy and fluoxetine. - WNCT,

FDA Warns Consumers Not to Use Two Brazilian Supplements for ...  Feb 8, 2006
...harmful. They contain chlordiazepoxide HCl (the active ingredient in Librium), and fluoxetine HCl (the active ingredient in Prozac). ... - Diet Drug Report,

Omnicare Shares Skid on Downgrade Sparked by Raid  Feb 5, 2006
...and "certain states" are investigating allegations that the company has been substituting antacid drug Ranitidine capsules for tablets; fluoxetine tablets for ... - ChallengerNKY.com,

Lower Switch Rate in Depressed Patients With Bipolar II Than ...  Feb 14, 2006
Amsterdam JD, Shults J, Brunswick DJ, Hundert M: Short-term fluoxetine monotherapy for bipolar type II or bipolar NOS major depression—low manic switch rate. ... - Am J Psychiatry (subscription)

DRL’s Beta gambit  Feb 17, 2006
After its remarkable success with Fluoxetine, which netted over $60 million (Rs 328.6 crore) during the 180-day period, a series of setbacks in the US played ... - Financial Express,

Playing pharmacist to friends  Feb 5, 2006
...who called herself Maggie earlier this month, saying that she had told her doctor she wanted to double her daily intake of the antidepressant fluoxetine to 40 ... - DetNews.com,

Love is the drug  Feb 11, 2006
Patients with compulsive disorders — such as nonstop hand-washing and bulimia — are often prescribed Prozac (fluoxetine hydrochloride), which increases the ... - The Sunday Times,

Early response to anti-bulimia drug a good sign  Feb 10, 2006
The investigators think it would be worthwhile to examine the pattern of response to fluoxetine and other widely used medications. - Reuters.uk,

Health Tip: Drugs to Avoid While Breast-Feeding  Feb 16, 2006
Antidepressant drugs: Amitriptyline, Amoxapine, Bupropion, Clomipramine, Desipramine, Dothiepin, Doxepin, Fluoxetine, Fluvoxamine, Imipramine, Nortriptyline ... - Forbes

Antidepressants in Pregnancy Linked to Newborn Hangover  Feb 7, 2006
In the Israeli study, 37 infants were exposed to Paxil (paroxetine), 12 to Prozac (fluoxetine), and the rest to Celexa (citalopram), Effexor (venlafaxine), or ... - CNN

Few Effective Treatments Exist for Borderline Personality Disorder  Feb 8, 2006
...to Fenton. “For ratings of anger, fluoxetine (Prozac) may offer some improvement over placebo,� the researchers say. Although ... - Health Behavior News Service

Class-action suit filed against Omnicare  Feb 6, 2006
...substituting capsules for tablets of Ranitidine, a generic form of the heartburn drug Zantac; giving tablets instead of capsules of Fluoxetine, a generic form ... - Louisville Business First,

Bristol-Myers Squibb Company and Otsuka Pharmaceutical Announce ...  Feb 8, 2006
Inhibitors of CYP3A4 (eg, ketoconazole) or CYP2D6 (eg, quinidine, fluoxetine, or paroxetine) can inhibit Abilify elimination and cause increased blood levels. ... - DG News

LSD faces an acid test as a pain killer  Feb 17, 2006
...take to alleviate the pain have also been known to interfere with LSD, notably selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine and other ... - Australian,

3 On Your Side: Cheaper Generic Prescriptions  Feb 13, 2006
Brooker showed us an example: "Fluoxetine, which is generic for Prozac, for 100 pills, we charge $19.99. It's double or triple that at any chain pharmacy.". ... - CBS 3,

Baby blues: Big dilemma?  Feb 17, 2006
According to Moses-Kolko, most antidepressant-related complications involve exposure to fluoxetine (Prozac) and paroxetine (Paxil). ... - myDNA.com,

Selective Serotonin-Reuptake Inhibitors and Risk of Persistent ...  Feb 9, 2006
A previous cohort study suggested a possible association between maternal use of the selective serotonin-reuptake inhibitor (SSRI) fluoxetine late in the third ... - New England Journal of Medicine (subscription),

Full Text  Feb 9, 2006
He notes that although tranquilizers normally help alleviate acute anxiety, benzodiazepine had no effect on the bullied mice, whereas fluoxetine (Prozac) had ... - Science Magazine (subscription)

Consumer Reports Medical Guide Addresses Differing Side Effects of ...  Feb 10, 2006
Consumer Reports Medical Guide can access detailed information about the safe use of drugs addressed in the report including fluoxetine (Prozac), nortriptyline ... - U.S. Newswire (press release),

ACNP Releases Final Task Force Report on Antidepressants and ...  Feb 14, 2006
In the summer of 2003 the UK Department of Health warned doctors against prescribing any serotonin reuptake inhibitor (SSRI) except fluoxetine for depressed ... - Psychiatric Services (subscription)

Shareholder Class Action Filed Against Omnicare, Inc. by the Law ...  Feb 13, 2006
Specifically, that the Company improperly substituted two 7.5-milligram Buspirone anti-anxiety tablets for one 15-milligram tablet, Fluoxetine anti-depression ... - Yahoo! News (press release)


Other information


Indication
For the initial treatment of advanced ovarian carcinoma in established combination with other approved chemotherapeutic agents. One established combination regimen consists of PARAPLATIN and cyclophosphamide.

Pharmacology
Carboplatin is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.

Mechanism Of Action
Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.

Drug Category
Antineoplastic Agents; ATC:L01XA02

Brand Names/Synonyms
Cbdca; Carboplatin (USAN); cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II); Platinum(II), (1, 1-cyclobutanedicarboxylato)diammine-, cis-; Platinum, {diammine[1,1-cyclobutanedicarboxylato(2-)-O,O']-,} (SP-4-2)-; Platinum, diamine(1, 1-cyclobutanedicarboxylato(2-)-O,O')-, (SP-4-2)-; Paraplatin; Paraplatin-AQ

Dosage Forms
SOLUTION

Absorption
Not Available

Interactions
Interactions for Carboplatin: The renal effects of nephrotoxic compounds may be potentiated by Carboplatin.

Chemical IUPAC Name
platinum;cyclobutane-1,1-dicarboxylicacid;azanide

Chemical Formula
C6H12N2O4Pt2

Half Life
1.1-2 hours

Drug Type
Approved Drug

# Accession No
APRD00466

CAS Registry Number
41575-94-4

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