Carbamazepine: profile and news

Blogbar: Latest Sabeer Bhatia Muse  07 Mar 2006
Hotmail founder, Sabeer Bhatia, has started an Internet-based toolbar called Blogeverywhere.com which promises to enhance the functionality and speed of ... - Techtree.com,

Pink Is Muse to Her Man  07 Mar 2006
American singer Pink is reportedly the inspiration behind the clothing line created by her husband, Carey Hart. Hart's company, Hart ... - soFeminine.co.uk,

LBSU in the NCAA tourney?  07 Mar 2006
Muse: Larry Reynolds' unheralded squad gave UC Irvine a 21-point first half lead, then routed them by 20 to finish the season 16-11 and a "warm" No. ... - Long Beach Press-Telegram,

Technology helping to speed up treatment at Pa. hospitals  07 Mar 2006
...histories. Dagen used MUSE software from General Electric to access the patient's EKG, which was obtained from a wireless cart. ... - Hagerstown Morning Herald,

Vikram Seth: my mother the muse  Mar 4, 2006
English literature, however resisted the idea. "I didn't like seeing my mother as a muse," he said. But he eventually decided to ... - ABC Online,

PROMAX&BDA Arabia Conference & Awards returns to Dubai: Regional ...  Mar 5, 2006
...designers. Throughout the world the PROMAX's Muse and BDA's Isis awards are recognised as the highest accolades within the industry. ... - AME Info,

Hicks, Muse, Tate & Furst renames itself HM Capital Partners  Mar 3, 2006
US private equity firm Hicks, Muse, Tate & Furst has renamed itself HM Capital Partners and has made changes to its senior management. ... - AltAssets

Bob Dylan: Courtney's New Muse  Mar 3, 2006
Courtney Love has quickly become better known for her red carpet outbursts than her on-stage talent, but if Bob Dylan has anything to do with it, we might soon ... - Spin,

Musing over mom’s muse  Mar 4, 2006
Devyani Saltzman was 11 when her filmmaker parents — Deepa Mehta and Paul Saltzman — decided to get a divorce. As she writes ... - Mumbai Mirror,

Muse Fest: local, live and female  Mar 3, 2006
By Jeffrey Lee Puckett. Muse Fest is a double shot of love for Louisville's arts scene, benefiting both its female contingent and one of its staunch supporters. ... - Louisville Courier-Journal,

Young musician discovers his muse downtown  Mar 5, 2006
By SCOTT JASON - Staff Writer. Dragor Cochrane, 12, was ready to quit fiddling two years ago when he decided to play at a farmers' market one Saturday. ... - Enterprise-Record,

Hilary Swank Is Muse of Upcoming Perfume  Feb 28, 2006
Swank will be both muse and spokesperson for a new women's fragrance by Guerlain to be launched later this year, the luxury French fragrance and beauty company ... - ABC News

Swank to be perfume company's muse  Feb 28, 2006
Hilary Swank will be both muse and spokesperson for a new women's fragrance by Guerlain to be launched later this year. In making ... - Scotsman,

Hilary Swank Is Muse of Upcoming Perfume  Feb 28, 2006
NEW YORK — Hilary Swank will be both muse and spokeswoman for a new women's fragrance by Guerlain to be launched later this year. ... - FOX News

Hollyfield named second team; Muse earns second-consecutive third ...  Mar 2, 2006
ST. PAUL, Minn. – Bemidji State University seniors Derik Hollyfield (G, Aurora, Ill.) and Alvin Muse (G, South Holland, Ill.) have each earned 2006 All ... - BSU Athletics,

Hicks, Muse changes its name, add partners  Mar 2, 2006
Hicks, Muse, Tate & Furst has changed its name following the addition of three partners to the firm. HM Capital added Edward Herring ... - Dallas Business Journal,

Muse & Brunch guests enjoy flavors of Europe  Feb 27, 2006
Installment Two of Saginaw Valley State University's Sunday Muse & Brunch outings may have caused a problem. It raised the bar so ... - The Saginaw News,

Commission wants to know how to improve Downtown  Mar 4, 2006
Is there enough new construction, the survey asks. "Yes, as far as residential there's plenty," said Lisa Doss, of Muse Clothing Boutique. ... - WMC-TV,

Hilary Swank is muse of upcoming perfume  Mar 1, 2006
By Associated Press. Hilary Swank will be both muse and spokesperson for a new women's fragrance by Guerlain to be launched later this year. ... - HappyNews.com,

Halle Berry is Eva Longoria's muse!  Mar 2, 2006
...'Desperate Housewives' star Eva Longoria wants to let herself go and show her dirty side in a gritty, dark film drama. The actress ... - Webindia123,

Daredevil Emilie Neumann Muse, 98  Feb 27, 2006
Emilie Neumann Muse, who as a young woman exemplified the crazy, flamboyant competitiveness of the '20s and '30s by swimming in treacherous waters, wrestling ... - Pioneer Press,

The Muse previews two of the bands playing in Boston over Spring ...  Mar 2, 2006
...have a laugh. "What did the number zero say to the letter H?" joked Caws in an interview with The Muse. "Nice belt!". After rising ... - Daily Free Press (subscription),

Dangerous Muse Download of the Week - iTunes.co.uk - February 28 ...  Feb 27, 2006
NEW YORK, NY -- (MARKET WIRE) -- 02/27/2006 -- Cordless Recordings artist, Dangerous Muse, will be the featured Download of the Week on iTunes UK's homepage ... - Market Wire (press release)

Muse, In Flames, Soulfly, Dreds en  Feb 28, 2006
De band; Muse, Jamiroquai, The Streets, David Gray, The Darkness, In Flames, Bushido, Babyshambles, Danko Jones, Soulfly, Alice In Chains, Bullet For My ... - Festivalinfo.nl,

Muse Confirmed for Summer Festival  Feb 28, 2006
Muse have confirmed their first festival appearance of the 2006, the band will join Kayne West, Tool and Depeche Mode at the Quart Festival in Kristiansand ... - albumvote.co.uk,

Muse ready return  Feb 27, 2006
Muse are understood to be on the brink of confirming full details of their new album. The band have been at the centre of speculation ... - DotMusic.com

Spot Muse: Larry Iwanko  Feb 28, 2006
My daughter is in the Gilbert and Sullivan group in Ellsworth. I went to her show. I don't eat breakfast. I had a cup of coffee. ... - Bangor Daily News,

News of the Muse  Feb 28, 2006
The Adi Foundation will present Flamenco Days for the 12th time between March 23-25 at the Suzanne Dellal Center in Tel Aviv. Featuring ... - Jerusalem Post,

Its Savior Is Kobe; Its Muse, the Dunk  Feb 19, 2006
By WILLIAM C. RHODEN. THE NBA All-Star Game is one of the most fascinating nonevent events in sports. All-Star weekend is a 72-hour ... - New York Times,

Daredevil Emilie Neumann Muse dead at 98  Feb 26, 2006
EAST PATCHOGUE, NY: Daredevil Emilie Neumann Muse, who swam the Hell Gate passage of the East River in 1929 among other stunts, has died in New York at age 98. ... - NewKerala.com,

Moss ex is Paris Hiltons musical muse!  Feb 20, 2006
Hotel heiress Paris Hilton has revealed that when it comes to her musical career, supermodel Kate Moss ex, troubled rocker Pete Doherty, is her muse. ... - Webindia123,

Muse Confirm Their Return With New Single  Feb 20, 2006
Muse have confirmed that their new single ‘A Crying Shame’ will be released on May 16. The single arrives the same month as ... - Gigwise,

West Remains Author's Muse  Feb 26, 2006
By Becky Bohrer Associated Press. BILLINGS, Mont. -- Mark Spragg is back to being anonymous, schlepping around, as he puts it, in ... - International News Service,

Emilie Muse, 98, Daredevil Who Dared Not Discuss Past, Dies  Feb 26, 2006
Emilie Neumann Muse, who as a young woman exemplified the crazy, flamboyant competitiveness of the 20's and 30's by swimming in treacherous waters, wrestling ... - New York Times,

Exhibit combines works by Picasso, his muse  Feb 22, 2006
...cow’s skull like a mask. Maar was Picasso’s muse and model, inspiring him with her beauty. He painted her with windblown hair ... - Columbus Dispatch,

Shah Rukh is her muse  Feb 22, 2006
In the 1990s, the 39-year-old Madhuri was the source of inspiration for Indian artist MF Husain. Now Shah Rukh Khan has the honour of being an artist's muse. ... - Electric New Paper,

Muse Name New Single  Feb 19, 2006
Muse are to release a new single called A Crying Shame on May 16th, Rolling Stone reports that it will be the first track lifted from their as-yet-untitled ... - albumvote.co.uk,

Guru voices the muse into action  Feb 22, 2006
BY ANDREW HARLEY. He may not be doing it with DJ Premier tonight, but the vocal half of the legendary hip-hop duo Gangstarr will ... - Summit Daily News,

MUSE: news ufficiali dal sito ufficiale  Feb 26, 2006
Dopo un periodo di indiscrezioni varie è proprio dal sito ufficiale che la band prende la parola per fare un po' di chiarezza sul nuovo album e sul futuro a ... - Ok Musik.com,

Other artists exhibiting work in 'The Black Muse' are: Jackie ...  Feb 24, 2006
...• Jackie Peters Cully was born in Key West and raised in Boston. She studied at the School of the Art Institute of Chicago, in ... - Bradenton Herald,

A different name for Hicks Muse  Mar 2, 2006
By KATHERINE YUNG / The Dallas Morning News. Dallas buyout firm Hicks, Muse, Tate & Furst Inc. said Wednesday that it is changing ... - Dallas Morning News (subscription),

DC Brands International Announces 2006 Muse Expo Sponsorship  Mar 1, 2006
DENVER, March 1 /PRNewswire-FirstCall/ -- At the close of business Tuesday, DC Brands International, Inc. (OTC: DCBI) announced ... - PR Newswire (press release),

Somalia: Puntland leadership fails to deliver  Mar 5, 2006
For months, president 'Adde Muse has been flying in and out of the region for medical reasons, while the public patiently waited for him to name his new Cabinet ... - Geeska Afrika,

Moss the muse Artist's bronze vision  Feb 5, 2006
...of his own blood frozen into a cast of his head and who put a sculpture of a pregnant, naked disabled woman on a Trafalgar Square plinth, has found a new muse. ... - Guardian Unlimited,

Clinically meaningful drug interactions have occurred with concomitant medications and include, but are not limited to the following:

Agents Highly Bound to Plasma Protein

Carbamazepine is not highly bound to plasma proteins; therefore, administration of EQUETRO^TM to a patient taking another drug that is highly protein bound should not cause increased free concentrations of the other drug.

Agents that Inhibit Cytochrome P450 Isoenzymes and/or Epoxide Hydrolase

Carbamazepine is metabolized mainly by cytochrome P450 (CYP) 3A4 to the active carbamazepine 10,11-epoxide, which is further metabolized to the trans-diol by epoxide hydrolase. Therefore, the potential exists for interaction between carbamazepine and any agent that inhibits CYP3A4 and/or epoxide hydrolase. Agents that are CYP3A4 inhibitors that have been found, or are expected, to increase plasma levels of EQUETRO^TM are the following:

Acetazolamide, azole antifungals, cimetidine, clarithromycin⁽¹⁾, dalfopristin, danazol, delavirdine, diltiazem, erythromycin⁽¹⁾, fluoxetine, fluvoxamine, grapefruit juice, isoniazid, itraconazole, ketoconazole, loratadine, nefazodone, niacinamide, nicotinamide, protease inhibitors, propoxyphene, quinine, quinupristin, troleandomycin, valproate⁽¹⁾, verapamil, zileuton.

Thus, if a patient has been titrated to a stable dosage of EQUETRO^TM, and then begins a course of treatment with one of these CYP3A4 or epoxide hydrolase inhibitors, it is reasonable to expect that a dose reduction for EQUETRO^TM may be necessary.

Agents that Induce Cytochrome P450 Isoenzymes

Carbamazepine is metabolized by CYP3A4. Therefore, the potential exists for interaction between carbamazepine and any agent that induces CYP3A4. Agents that are CYP inducers that have been found, or are expected, to decrease plasma levels of EQUETRO^TM are the following:

Cisplatin, doxorubicin HCL, felbamate, rifampin, phenobarbital, Phenytoin⁽²⁾, primidone, methsuximide, and theophylline

Thus, if a patient has been titrated to a stable dosage on EQUETRO^TM, and then begins a course of treatment with one of these CYP3A4 inducers, it is reasonable to expect that a dose increase for EQUETRO^TM may be necessary.

Agents with Decreased Levels in the Presence of Carbamazepine due to Induction of Cytochrome P450 Enzymes

Carbamazepine is known to induce CYP1A2 and CYP3A4. Therefore, the potential exists for interaction between carbamazepine and any agent metabolized by one (or more) of these enzymes. Agents that have been found, or are expected to have decreased plasma levels in the presence of EQUETRO^TM due to induction of CYP enzymes are the following:

Acetaminophen, alprazolam, amitriptyline, bupropion, buspirone, citalopram, clobazam, clonazepam, clozapine, cyclosporin, delavirdine, desipramine, diazepam, dicumarol, doxycycline, ethosuximide, felbamate, felodipine, glucocorticoids, haloperidol, itraconazole, lamotrigine, levothyroxine, lorazepam, methadone, midazolam, mirtazapine, nortriptyline, olanzapine, oral contraceptives⁽³⁾, oxcarbazepine, Phenytoin⁽⁴⁾, praziquantel, protease inhibitors, quetiapine, risperidone, theophylline, topiramate, tiagabine, tramadol, triazolam, valproate, warfarin⁽⁵⁾ , ziprasidone, and zonisamide.

Thus, if a patient has been titrated to a stable dosage on one of the agents in this category, and then begins a course of treatment with EQUETRO^TM, it is reasonable to expect that a dose increase for the concomitant agent may be necessary.

Agents with Increased Levels in the Presence of Carbamazepine:

EQUETRO^TM increases the plasma levels of the following agents:

Clomipramine HCl, Phenytoin⁽⁶⁾, and primidone

Thus, if a patient has been titrated to a stable dosage on one of the agents in this category, and then begins a course of the treatment with EQUETRO^TM, it is reasonable to expect that a dose decrease for the concomitant agent may be necessary.

Pharmacological/Pharmacodynamic Interactions with Carbamazepine

Concomitant administration of carbamazepine and lithium may increase the risk of neurotoxic side effects.

Given the anticonvulsant properties of carbamazepine, EQUETRO^TM may reduce the thyroid function as has been reported with other anticonvulsants. Additionally, anti-malarial drugs, such as chloroquine and mefloquine, may antagonize the activity of carbamazepine.

Thus if a patient has been titrated to a stable dosage on one of the agents in this category, and then begins a course of treatment with EQUETRO^TM, it is reasonable to expect that a dose adjustment may be necessary.

Because of its primary CNS effect, caution should be used when EQUETRO^TM is taken with other centrally acting drugs and alcohol.