Carac: profile and news

AP Pharma Completes Financing for up to $30 Million; Sells Royalty ... Jan 18, 2006
AP Pharma, Inc. (NASDAQ:APPA) today announced that it has sold rights to future royalties on sales of Retin-A Micro(R) and Carac(R) to an affiliate of the Paul ... - Genetic Engineering News,

AP Pharma makes $30M royalty sale to prevent delisting Jan 18, 2006
AP Pharma gets royalties on the sales of Retin-A Micro and Carac through license agreements with Ortho Neutrogena (formerly Ortho Dermatological), a Johnson & ... - Bizjournals.com,

New look on its way, Love says Oct 26, 2005
SKIN CANCER AWARENESS: PGA Tour player Steve Flesch was at the Carac Sponsorship Tent on Wednesday afternoon as part of a skin cancer public awareness program ... - St. Petersburg Times,

Dermik Labs move may cost jobs Oct 18, 2005
Its other products include Carac, a treatment for precancerous skin lesions; Dermatop and Klaron, for eczema; and Penlac, for nail fungus. ... - Philadelphia Business Journal,

PGA Tour Star Steve Flesch and Dermik Laboratories Partnered ... Jul 7, 2005
My dermatologist treated me with Carac® (fluorouracil cream) Cream, 0.5% and it worked for me" said Steve Flesch, PGA Tour golfer. ... - Yahoo News (press release)

Treatment of Verruca Plantaris with a Combination of Topical ... Jul 21, 2005
Jersey), followed by either 5.0% fluorouracil cream (Efudex; ICN Pharmaceuticals, Costa Mesa, California) or 0.5% fluorouracil cream (Carac; Dermik Laboratories ... - Journal of the American Podiatric Medical Association <**results**>

Better Breast Cancer Care? Jun 1, 2005
...from around the world set out to study how the drug docetaxel (also known as Taxotere) compares to the drug fluorouracil (known as Fluoroplex, Carac, Efudex or ... - Ivanhoe

Forge Sponsorship Consulting Announces New Hires, a New Client ... Apr 14, 2005
Joe Amdor is managing Forge’s Event Marketing division which will include both Cingular’s and Sanofi-aventis brand Carac’s PGA TOUR on-site programs. ... - New Age Media Concepts

Treatment With Carac(R) (Fluorouracil Cream) Cream, 0.5% Prior to ... Feb 22, 2005
Academy of Dermatology Annual Meeting this past weekend indicate that a one-week course of treatment with the topical 0.5% fluorouracil cream Carac(R) before ... - Forbes

AP Pharma Reports 2004 Fourth Quarter and Full Year Results; IND ... Mar 10, 2005
...increase of 13%. Fourth quarter royalties on sales of Retin-A Micro and Carac grew by 10% and 18%, respectively. Contract revenues ... - Business Wire (press release),

Other information

Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.

Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.

Mechanism Of Action
Fluorouracil inhibits thymidylate synthetase, leading to inhibition of DNA and RNA synthesis and cell death.

Drug Category
Immunosuppressive Agents; Antimetabolites; Antimetabolites; Antineoplastic Agents; ATC:L01BC02

Brand Names/Synonyms
5 Fluorouracil; Adrucil; Arumel; Carac; Carzonal; Effluderm; Efudex; Efudix; Efurix; FT-207; FU; Fluoroblastin; Fluoroplex; Fluorouracil; Fluracil; Fluracilum; Fluri; Fluril; Fluro Uracil; Ftoruracil; Kecimeton; NSC 19893; NSC-19893; Phthoruracil; Phtoruracil; Queroplex; Timazin; U 8953; U-8953; URF; Ulup

Dosage Forms
Topical preparations, Solution for injection

Absorption
28-100%

Interactions
-->Interactions for Fluorouracil:

No information available.

Chemical IUPAC Name
5-fluoro-1H-pyrimidine-2,4-dione

Chemical Formula
C4H3FN2O2

Half Life
10-20 minutes

Drug Type
Approved Drug

# Accession No
APRD00516

CAS Registry Number
51-21-8