Captopril: profile and news

Attempts to Recruit Stem Cells for Repair of Acute Myocardial ...  Feb 28, 2006
Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction: results of the survival and ... - Journal of American Medical Association (subscription),

Coughing fits stump doctors  Feb 8, 2006
I thought maybe it was one of her drugs, such as Captopril, but then it seems like she would cough all the time, but she does not. ... - Northwest Herald,

Coughing fits stump doctors  Feb 8, 2006
I thought maybe it was one of her drugs, such as Captopril, but then it seems like she would cough all the time, but she does not. ... - Northwest Herald,

New drugs use saliva to help relieve pain  Jan 10, 2006
Captopril was the first drug approved from snake venom in a series of angiotensin-converting enzyme inhibitors to control blood pressure. ... - Auburn Citizen,

Loss of taste, smell often tied to high blood pressure, meds  Jan 24, 2006
...commonly reported to cause taste loss include diuretics (water pills) such as hydrochlorothiazide, and ACE inhibitors such as captopril (Capoten), enalapril ... - Charlotte Observer,

Side benefits of ACE inhibitors  Dec 4, 2005
Diabetics on insulin who have kidney problems are often prescribed an ACE inhibitor such as captopril which has been shown to slow progression of kidney disease ... - Enid News & Eagle,

Aging just one cause for loss of taste  Nov 21, 2005
...commonly reported to cause taste loss include diuretics (water pills) such as hydrochlorothiazide, and ACE inhibitors, such as captopril (Capoten), enalapril ... - Charleston Post Courier (subscription),

Anti-anxiety treatment found effective in lowering blood pressure  Oct 9, 2005
Israel, designed a study to compare the efficacy and safety of antianxiety treatment with the common practice of sublingual captopril administration in ... - MedIndia,

Good news for heart attack survivors  Sep 21, 2005
...attack. VALIANT was a rigorous comparison of Diovan(*) vs. captopril, an angiotensin converting enzyme (ACE) inhibitor, vs. the ... - Canada NewsWire (press release),

What to do when you're lacking in taste  Sep 19, 2005
Some common medications that can cause taste abnormalities are captopril, spironolactone, amitriptyline, lithium, phenytoin and carbamazepine. ... - Newark Star Ledger,

FDA Approvals: Diovan, Celebrex, Adderall XR  Aug 4, 2005
...from the VALsartan In Acute myocardial iNfarcTion (Valiant) trial in 14,703 patients, showing that valsartan was similarly effective to captopril in reducing ... - Medscape (subscription)

Diovan to reduce cardiovascular death in heart attack survivors at ...  Aug 5, 2005
...myocardial infarction ). VALIANT was a rigorous comparison of Valsartan vs. Captopril ( an ACE inhibitor ) vs. the combination of ... - Xagena.it

UPDATE 1-FDA OKs new uses for Novartis blood pressure drug  Aug 3, 2005
...high-risk heart attack survivors follows the drug's favorable showing in a large clinical trial than pitted it against the widely used ACE inhibitor captopril. ... - Reuters

FDA Approves Diovan(R) (Valsartan) to Reduce Cardiovascular Death ...  Aug 3, 2005
...suffered a heart attack. VALIANT was a rigorous comparison of Diovan vs. captopril, an ACE inhibitor, vs. the combination of both ... - Finanzen.net

Race influences prostate cancer behavior  Jul 29, 2005
...failure among other heart-related conditions. Common examples of ACE inhibitors are Benazepril, Captopril, Cilazapril and Lisinopril. - myDNA.com <**results**>

McKesson plans outsourcing deals in India  Jun 28, 2005
McKesson already retails Wockhardt's generic anti-hypertension drug, Captopril, in its American stores. Captopril is one of the ... - Moneycontrol.com

Keryx Biopharmaceuticals, Inc. Initiates Pivotal Phase 3 and Phase ...  Jun 29, 2005
CSG), the world's largest standing renal clinical trial group, whose execution of the angiotensin-converting enzyme (ACE) inhibition trial of captopril in Type ... - Yahoo News (press release)

Treatment offers hope for heart attack survivors in the Middle ...  Jun 13, 2005
VALIANT demonstrated that Diovan preserved the benefit of captopril, which is one essential component of the currently recommended standard of care in these ... - AME Info

Risk of Sudden Death and Cardiac Arrest is Greatest in 30 Days ...  Jun 22, 2005
...first or second MI complicated by heart failure, left ventricular systolic dysfunction or both to treatment with Diovan (valsartan), Capoten (captopril) or both ... - MedPage Today,

Diovan receives EU approval to treat people after heart attacks  May 27, 2005
VALIANT demonstrated that Diovan preserved the benefit of Captopril, which is one essential component of the currently recommended standard of care in these ... - Xagena.it,

Risk of Sudden Death and Cardiac Arrest is Greatest in 30 Days ...  Jun 22, 2005
...first or second MI complicated by heart failure, left ventricular systolic dysfunction or both to treatment with Diovan (valsartan), Capoten (captopril) or both ... - MedPage Today,

Treatment offers hope for heart attack survivors in the Middle ...  Jun 13, 2005
VALIANT demonstrated that Diovan preserved the benefit of captopril, which is one essential component of the currently recommended standard of care in these ... - AME Info,

Hemispherx Biopharma's Investigational Drug Increases Physical ...  Apr 11, 2005
For example, in CHF: Fosinopril (6.7% improvement), Captopril (6.2%), Ranolazine (6.5%) and Ranolazine (5.7%); in AI, Tracleer (10.6% improvement), Remodulin ... - Business Wire,

Venom as a Prelude to New Drug Treatments  Mar 6, 2005
Already, venoms from snakes and other creatures have led to the development of important medications, including the blood pressure drug captopril, which is a ... - Washington Post

Many things can cause metallic taste  Feb 28, 2005
...a metallic taste are antiobiotics such as Biaxin (clarithromycin) and Flagyl (metronidazole); drugs used to treat an overactive thyroid; captopril, used to ... - Arizona Republic,

Angiotensin-Converting Enzyme Inhibitors and Angiotensin-Receptor ...  Feb 28, 2005
Finally, we agree with Mr. Regier and Mr. Jensen that in our Table, the doses of valsartan and captopril in the VALIANT study were reported as the target doses ... - Annals of Internal Medicine

Diagnosis and Treatment of Renovascular Hypertension: A Cost ...  Feb 23, 2005
We sought to evaluate and compare the relative cost–benefit of Doppler sonography, MR angiography, and captopril-enhanced renal scintigraphy as techniques ... - Am J Roentgenology (subscription)

BCBSNC Launches New Prescription Drug Savings Initiative  Feb 17, 2005
...generic Corgard) propranolol (generic Inderal) ACE INHIBITORS (Drugs to Treat High Blood Pressure) benazepril (generic Lotensin) captopril (generic Capoten ... - PR Newswire (press release)

Update on Risk Factors for Atherosclerosis: The Role of ...  Feb 26, 2005
Regression of left ventricular mass with captopril and metoprolol, and the effects on glucose and lipid metabolism. Blood Pressure, 10(2), 101-110. ... - RedNova.com,

Hypotension ó Patients on Diuretic Therapy: Patients on diuretics and especially those in whom diuretic therapy was recently instituted, as well as those on severe dietary salt restriction or dialysis, may occasionally experience a precipitous reduction of blood pressure usually within the first hour after receiving the initial dose of captopril.

The possibility of hypotensive effects with captopril can be minimized by either discontinuing the diuretic or increasing the salt intake approximately one week prior to initiation of treatment with captopril (captopril tablets, USP) or initiating therapy with small doses (6.25 or 12.5 mg). Alternatively, provide medical supervision for at least one hour after the initial dose. If hypotension occurs, the patient should be placed in a supine position and, if necessary, receive an intravenous infusion of normal saline. This transient hypotensive response is not a contraindication to further doses which can be given without difficulty once the blood pressure has increased after volume expansion.

Agents Having Vasodilator Activity: Data on the effect of concomitant use of other vasodilators in patients receiving captopril for heart failure are not available; therefore, nitroglycerin or other nitrates (as used for management of angina) or other drugs having vasodilator activity should, if possible, be discontinued before starting captopril. If resumed during captopril therapy, such agents should be administered cautiously, and perhaps at lower dosage.

Agents Causing Renin Release

Captoprilís effect will be augmented by antihypertensive agents that cause renin release. For example, diuretics (e.g., thiazides) may activate the renin-angiotensin-aldosterone system.

Agents Affecting Sympathetic Activity

The sympathetic nervous system may be especially important in supporting blood pressure in patients receiving captopril alone or with diuretics. Therefore, agents affecting sympathetic activity (e.g., ganglionic blocking agents or adrenergic neuron blocking agents) should be used with caution. Beta-adrenergic blocking drugs add some further antihypertensive effect to captopril, but the overall response is less than additive.

Agents Increasing Serum Potassium

Since captopril decreases aldosterone production, elevation of serum potassium may occur. Potassium-sparing diuretics such as spironolactone, triamterene, or amiloride, or potassium supplements should be given only for documented hypokalemia, and then with caution, since they may lead to a significant increase of serum potassium. Salt substitutes containing potassium should also be used with caution.

Inhibitors Of Endogenous Prostaglandin Synthesis

It has been reported that indomethacin may reduce the antihypertensive effect of captopril, especially in cases of low renin hypertension. Other nonsteroidal anti-inflammatory agents (e.g., aspirin) may also have this effect.

Lithium

Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving concomitant lithium and ACE inhibitor therapy. These drugs should be coad-ministered with caution and frequent monitoring of serum lithium levels is recommended. If a diuretic is also used, it may increase the risk of lithium toxicity.

Cardiac Glycosides

In a study of young healthy male subjects no evidence of a direct pharmacokinetic captopril-digoxin interaction could be found.

Loop Diuretics: Furosemide administered concurrently with cap-topril does not alter the pharmacokinetics of captopril in renally impaired hypertensive patients.

Allopurinol

In a study of healthy male volunteers no significant pharmacokinetic interaction occurred when captopril and allop-urinol were administered concomitantly for 6 days.

Drug/Laboratory Test Interaction

Captopril may cause a false-positive urine test for acetone.