Calcitriol: profile and news
ASCO Prostate: Intermittent Chemotherapy Controls Androgen ... Feb 28, 2006
...who participated in the phase III randomized ASCENT trial, which compared Taxotere (docetaxel) plus a high-dose vitamin D supplement (Calcitriol) to Taxotere ... - MedPage Today,
Treatment “Holidays� Effective in Hormone-Refractory Prostate ... Mar 1, 2006
...of 45 patients involved in a larger clinical trial referred to as the ASCENT trial in which treatment with Taxotere® (docetaxel) plus Calcitriol (high-dose ... - Cancer Consultants (press release),
Calcium Benefits for Better Health Feb 20, 2006
Your kidneys also deliver a dose of a hormone called calcitriol, a form of vitamin D, to increase your ability to absorb calcium. ... - DailyIndia.com,
Local Anesthesia Rivaling General for Thyroid Surgery Feb 20, 2006
...the study required inpatient management of symptomatic hypocalcemia with the increased administration of oral calcium and short-acting vitamin D, or calcitriol ... - MedPage Today,
Teva and Ivax Cleared to Complete Merger Jan 27, 2006
...generic distribution relationships that Ivax had with respect to certain amoxicillin, amoxicillin and clavulanate, leuprolide, and calcitriol products have ... - International News Service,
FTC gives Ivax and Teva final go-ahead for merger Jan 23, 2006
...the companies said generic distribution relationships Ivax had for certain amoxicillin, amoxicillin and clavulanate, leuprolide, and calcitriol products have ... - South Florida Business Journal,
Sapphire Therapeutics, Inc. Appoints New Director and Scientific ... Jan 17, 2006
The second drug, RC-8800, is a small molecule that acts on the vitamin D (calcitriol) metabolic pathway, being developed as a treatment for various cancers ... - Genetic Engineering News,
Preserving Competition, FTC Requires Divestitures Before Allowing ... Jan 23, 2006
...tablets from Teva, to be divested to Barr; 13) glipizide and metformin hydrochloride tablets from IVAX, to be divested to Barr; 14) calcitriol injectables from ... - PharmaLive.com (press release),
Sapphire Therapeutics, Inc. Builds Drug Development Team Through ... Jan 9, 2006
The second drug, RC-8800, a small molecule that acts on the vitamin D (calcitriol) metabolic pathway, is being developed as a treatment for various cancers ... - dBusinessNews Newark (press release),
Calcitriol and QW-1624-F2-2 are promising for prevention of ... Nov 20, 2005
Research's 4th annual Frontiers in Cancer Prevention Research meeting in Baltimore, has found that the active metabolite of vitamin D, Calcitriol, and other ... - Xagena.it,
Vitamin D May Help Treat Some Asthma Dec 8, 2005
That limits their treatment options. The form of vitamin D used in this study was calcitriol, or vitamin D-3. It's the form of vitamin D that the body uses. ... - WebMD
FAMILY DOCTOR: LIchen sclerosis affects sexual function Dec 9, 2005
New treatments are under investigation, one of which is calcitriol (a chemical related to vitamin D). Another is the use of pimecrolimus cream. ... - Canton Repository (subscription),
Vitamin D plus taxotere extends lives of men with advanced ... Nov 7, 2005
Designed specifically as a cancer therapy, it is a unique form of calcitriol, a naturally occurring hormone and the biologically active form of vitamin D ... - Medical News Today (press release),
Vitamin D sufficiency may be more important than high calcium ... Nov 10, 2005
...hormone is a major hormone maintaining normal serum concentrations of calcium and phosphate and is itself regulated through levels of calcitriol and serum ... - News-Medical.net,
Long-Term Exposure to Warfarin Associated with Aortic Valve ... Nov 11, 2005
...linear regression analysis showed that predictors of AV calcification included lifetime months of warfarin (P = .012), daily dose of calcitriol (P = .017) and ... - DG News
Calcitriol Can Be Safely Added to Chemotherapy for Prostate Cancer Sep 23, 2005
NEW YORK SEP 22, 2005 (Reuters Health) - High-dose pulse calcitriol along with docetaxel and estramustine appears to be generally well tolerated, according to ... - Cancerpage.com,
The Washington Legal Foundation (WLF) today called on DDMAC to ... Oct 4, 2005
...to withdraw a warning letter sent to Nephrx, LLC on September 30, 2005 regarding Nephrx's allegedly improper promotion of Calcitriol on Nephrx's web site and ... - PharmaLive.com (press release),
Tumor-Induced Osteomalacia Sep 13, 2005
...severe pain persisted. Once calcitriol was added to the phosphorus, my symptoms improved substantially within 6 months. DR JAN DE ... - Journal of American Medical Association (subscription),
Rejuvenon Corp. Changes Name to Sapphire Therapeutics, Inc. ... Oct 5, 2005
The second drug, RC-8800, is a small molecule that acts on the vitamin D (calcitriol) metabolic pathway, being developed as a treatment for various cancers ... - Genetic Engineering News,
Calcitriol [Vitamin D] with combination of painkillers for cancer ... Sep 7, 2005
The research team is testing the effect of Calcitriol, which is a form of Vitamin D that is efficiently metabolized by the body and more effective than other ... - MedIndia,
Calcitriol and NSAIDs Together Block Rrostate Cancer Cell Growth Sep 2, 2005
NEW YORK SEP 01, 2005 (Reuters Health) - Findings from a laboratory study show that calcitriol and NSAIDs act synergistically to inhibit the growth of prostate ... - Cancerpage.com,
Prostate Cancer Growth Slowed Dramatically by Vitamin D with Pain ... Sep 1, 2005
...senior author, Feldman, who has been studying vitamin D for 25 years, had shown in previous studies that a form of the vitamin, known as calcitriol, limits the ... - SeniorJournal.com,
Vitamin D, NSAIDS Provide Double Whammy Against Prostate Cancer ... Sep 1, 2005
...professor of medicine, who has been studying vitamin D for 25 years, had shown in previous studies that a form of the vitamin, known as calcitriol, limits the ... - Science Daily (press release)
Activated vitamin D and NSAIDs form one-two punch against prostate ... Aug 31, 2005
...in the journal "Cancer Research", scientists from Stanford University discovered that the amount of both -- activated vitamin D, or calcitriol, and the NSAIDs ... - EurekAlert,
Vitamin D boosts NSAID cancer-fighting power Sep 2, 2005
Writing in Cancer Research, a team from Stanford University says it discovered that the amount of both activated vitamin D, or calcitriol, and NSAIDs could be ... - NutraIngredients.com,
Vitamin D, NSAIDS Provide Double Whammy Against Prostate Cancer Sep 1, 2005
Calcitriol, the active form of vitamin D, is the metabolite that is created in the body after consumption of vitamin D-containing food or exposure to the sun. ... - eMaxHealth.com,
Vitamin D Can Halt Growth Of Cancer Cells Sep 5, 2005
The trial used Calcitriol, a form of vitamin D available only by prescription, and Naproxen, sold over the counter as Aleve, and other brand names. ... - 13WHAM-TV,
Double whammy of vitamin D and anti-inflammatory zaps prostrate ... Sep 6, 2005
In this study, activated vitamin D or calcitriol was shown to act as a triple threat against this pathway, in prostate cancer cells by first limiting the ... - News-Medical.net,
Vitamin D and Painkiller Slow Prostate Cancer Sep 1, 2005
The trial used calcitriol, a form of vitamin D available only by prescription, and naproxen, sold over the counter as Aleve and other brand names. ... - Forbes
Vitamin D, painkillers battle prostate cancer Sep 1, 2005
Feldman stressed that his team is testing calcitriol, a form of vitamin D that is efficiently used by the body and different from the sort found in vitamin ... - Reuters AlertNet,
Vitamin D, painkillers battle prostate cancer: Sep 2, 2005
It's hard to make an exact comparison, as we are talking about cells in a dish and not a person.'' Feldman stressed that his team is testing calcitriol, a form ... - NewKerala.com,
Vitamin D-NSAID Duo Shows Promise Against Prostate Cancer Sep 1, 2005
1-When Rocaltrol (calcitriol) and various over-the-counter NSAIDs join forces, they pack a powerful punch against prostate cancer cells -- at least in a Petri ... - MedPage Today,
Vitamin D-NSAID Duo Shows Promise Against Prostate Cancer Sep 4, 2005
1-When Rocaltrol (calcitriol) and various over-the-counter NSAIDs join forces, they pack a powerful punch against prostate cancer cells -- at least in a Petri ... - Borsa-Italia.Net,
Drugs 'may combat prostate cancer' Sep 1, 2005
...in its "active" form. Active vitamin D, known as calcitriol, also holds back prostate cancer on its own. But the research indicates ... - Daily Mail - UK,
Vitamin D and NSAIDs Slow Prostate Cancer Aug 31, 2005
In a study published in the journal Cancer Research, Stanford University researchers say the dosage of both activated vitamin D, or calcitriol, and the NSAIDs ... - RedNova.com,
Little Miss Muffet's whey found to aid weight loss Aug 3, 2005
One of those hormones (calcitriol) unfortunately also sends messages to your fat cells that interfere with the biochemical machinery involved with fat breakdown ... - South Bend Tribune
Rejuvenon's RC-8800 for Prostate Cancer Enters Human Testing; RC ... Jul 20, 2005
...disorders, has initiated a Phase I study of its second investigational drug, RC-8800, a small molecule that acts on the vitamin D (calcitriol) metabolic pathway ... - PharmaLive.com (press release)
Vitamin D, Taxotere Combination Promising For Advanced Prostate ... Jul 12, 2005
Results of a new study strongly suggest that DN-101, a new high-dose calcitriol pill designed specifically as a cancer therapy, given in combination with ... - eMaxHealth.com
Diet experts tackle 12 weight-loss questions Jul 25, 2005
Zemel explains that a high-calcium diet -- 1,200 milligrams per day -- inhibits the production of calcitriol, a hormone that "tells" cells to generate more fat ... - DetNews.com
Elderly benefit from calcium and vitamin D combo, confirms review Jul 21, 2005
Synthetic vitamin D in drugs such as calcitriol (Rocaltrol) did not appear to have any advantage in preventing bone fracture and may be more likely to cause ... - NutraIngredients.com
ON NUTRITION: HELAYNE WALDMAN Vitamin D plays crucial role in well ... Jul 12, 2005
...is exposed to the UVB part of the ultraviolet spectrum, a compound in the skin is transformed into a precursor of vitamin D (called D3 or calcitriol), which is ... - Contra Costa Times
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Vitamin D: The New Wonder Vitamin Jul 1, 2005
If your dietary intake of calcium is inadequate, calcitriol in combination with parathyroid hormone can mobilize calcium stores from your bones. ... - Christian Post
A Long-Term, Open-Label Extension Study on the Safety of Treatment ... Jun 11, 2005
Increasing serum phosphorus levels disrupt the delicate balance between calcium, parathyroid hormone (PTH), and calcitriol, and directly stimulate PTH ... - RedNova.com,
Other information
Indication
Used to treat vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis.
Pharmacology
Calcitriol, a pharmaceutical form of vitamin D, has anti-osteoporotic, immunomodulatory, anticarcinogenic, antipsoriatic, antioxidant, and mood-modulatory activities. Calcitriol has been found to be effective in the treatment of psoriasis when applied topically. Calcitriol has been found to induce differentiation and/or inhibit cell proliferation in a number of malignant cell lines including human prostate cancer cells. Vitamin D deficiency has long been suspected to increase the susceptibility to tuberculosis. The active form of Calcitriol, 1,25 (OH)2 D, has been found to enhance the ability of mononuclear phagocytes to suppress the intracellular growth of Mycobacterium tuberculosis. 1,25(OH)2D has demonstrated beneficial effects in animal models of such autoimmune diseases as rheumatoid arthritis. It has also been found to induce monocyte differentiation and to inhibit lymphocyte proliferation and production of cytokines, including interleukin IL-1 and IL-2, as well as to suppress immunoglobulin secretion by B lymphocytes. Vitamin D appears to demonstrate both immune-enhancing and immunosuppressive effects.
Mechanism Of Action
The mechanism of action of Calcitriol in the treatment of psoriasis is accounted for by their antiproliferative activity for keratinocytes and their stimulation of epidermal cell differentiation. The anticarcinogenic activity of the active form of Calcitriol appears to be correlated with cellular vitamin D receptor (VDR) levels. Vitamin D receptors belong to the superfamily of steroid-hormone zinc-finger receptors. VDRs selectively bind 1,25(OH)2D and retinoic acid X receptor (RXR) to form a heterodimeric complex that interacts with specific DNA sequences known as vitamin D-responsive elements. VDRs are ligand-activated transcription factors. The receptors activate or repress the transcription of target genes upon binding their respective ligands. It is thought that the anticarcinogenic effect of Calcitriol is mediated via VDRs in cancer cells. The immunomodulatory activity of Calcitriol is thought to be mediated by vitamin D receptors (VDRs) which are expressed constitutively in monocytes but induced upon activation of T and B lymphocytes. 1,25(OH)2D has also been found to enhance the activity of some vitamin D-receptor positive immune cells and to enhance the sensitivity of certain target cells to various cytokines secreted by immune cells.
Drug Category
ATC:A11CC04; ATC:D05AX03; Antihypocalcemic Agents; Antihypoparathyroid Agents; Essential Vitamin; Vitamins (Vitamin D)
Brand Names/Synonyms
Calcijex; Calcitriol; Rocaltrol
Dosage Forms
Capsule, solution
Absorption
Rapidly absorbed from the intestine.
Interactions