CCNU: profile and news

Garage fire reveals marijuana operation Feb 25, 2006
Agents with CCNU, the Law Enforcement Against Drugs task force from the Lower Valley and the federal Drug Enforcement Administration spent much of the day ... - Yakima Herald-Republic,

Differential Chemosensitivity of Tumor Components in a Malignant ... Feb 11, 2005
...year-old man who underwent diffusion-weighted, perfusion-weighted, and volumetric MR imaging before and after PCV (procarbazine, CCNU, vincristine) chemotherapy ... - Am J Neuroradiology (subscription)

Other information

Indication
For use as a single agent in addition to other treatment modalities to treat brain tumors and Hodgkin's disease

Pharmacology
Although it is generally agreed that CeeNU alkylates DNA and RNA, it is not cross resistant with other alkylators. As with other nitrosoureas, it may also inhibit several key enzymatic processes by carbamoylation of amino acids in proteins.

Mechanism Of Action
Lomustine is a highly lipophilic nitrosourea compound which undergoes hydrolysis in vivo to form reactive metabolites. These metabolites cause alkylation and cross-linking of DNA. Other biologic effects include inhibition of DNA synthesis and some cell cycle phase specificity. Nitrosureas generally lack cross-resistance with other alkylating agents

Drug Category
Antineoplastic Agents; ATC:L01AD02

Brand Names/Synonyms
Belustine; CCNU; CCRIS 860; CHEMBANK4359; Ccnu [Chloroethyl Nitrosoureas]; Cecenu; Ceenu; Ceenu®; Chloroethylcyclohexylnitrosourea; Cinu; Cyclohexyl Chloroethyl Nitrosourea; HSDB 6519; ICIG 1109; Lomustina [Inn-Spanish]; Lomustine; Lomustine [Usan:Ban:Inn]; Lomustinum [Inn-Latin]; RB 1509; SRI 2200; [Inn-Spanish]

Dosage Forms
CAPSULES

Absorption
Rapidly and completely absorbed (in 30-60 minutes)

Interactions
Interactions for Lomustine:

No Information Provided.

Chemical IUPAC Name
1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-urea

Chemical Formula
C9H16ClN3O2

Half Life
16 hours-2 days

Drug Type
Approved Drug

# Accession No
APRD00292

CAS Registry Number
13010-47-4