Butabarbital: profile and news

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The non-medical use of drugs belonging to this class, including, but not limited to, Amobarbital (Amytal), Butabarbital (Butisol), Butalbital (Anolor 300, Esgic ... - Pro Wrestling Insider,

Other information

Indication
For short-term treatment of insomnia and anxiety disorders

Pharmacology
Butabarbital, a barbiturate, is used for the treatment of short term insomnia. It belongs to a group of medicines called central nervous system (CNS) depressants that induce drowsiness and relieve tension or nervousness. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation.

Mechanism Of Action
Butabarbital binds at a distinct binding site associated with a Cl^- ionopore at the GABA_A receptor, increasing the duration of time for which the Cl^- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. All of these effects are associated with marked decreases in GABA-sensitive neuronal calcium conductance (gCa). The net result of barbiturate action is acute potentiation of inhibitory GABAergic tone. Barbiturates also act through potent (if less well characterized) and direct inhibition of excitatory AMPA-type glutamate receptors, resulting in a profound suppression of glutamatergic neurotransmission.

Drug Category
Anti-anxiety Agents; Hypnotics and Sedatives; Barbiturates; ATC:N05CA

Brand Names/Synonyms
Butabarb; Butabarbital; Butabarbital Sodium; Butabarbitone; Butalan; Butatab; Butatal; Buticaps; Butisol; Butisol Sodium; Butrate; Medarsed; Nilox; Sarisol; Sarisol No. 1; Secbubarbital; Secbutabarbital; Secbutobarbital; Secbutobarbitone; Sodium Butabarbital; Unicelles

Dosage Forms
TABLET

Absorption
Not Available

Interactions
Interactions for Butabarbital:
Interactions may occur with the following: adrenocorticoids (cortisone-like medicine), anticoagulants (blood thinners), carbamazepine, corticotropin (barbiturates may decrease the effects of these medicines), central nervous system (CNS) depressants (using these medicines with barbiturates may result in increased CNS depressant effects), divalproex sodium, valproic acid (using these medicines with barbiturates may change the amount of either medicine that you need to take), and oral contraceptives containing estrogens (barbiturates may decrease the effectiveness of these oral contraceptives, and you may need to change to a different type of birth control).

Chemical IUPAC Name
5-ethyl-5-(1-methylpropyl)hexahydropyrimidine-2,4,6-trione

Chemical Formula
C10H16N2O3

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00752

CAS Registry Number
125-40-6