Buspirone: profile and news
Jagged little pills Mar 2, 2006
...of his bedroom dresser. "Buspirone, Paxil, Trazodone, Celexa, Zyprexa," he continues. "Those are the main ones.". He threw out the ... - Silver Chips Online,
STAR*D Preliminary Findings Provide Clearer Picture of Major ... Feb 27, 2006
SR (Wellbutrin SR), sertraline (Zoloft), venlafaxine XR (Effexor XR) or cognitive therapy (CT) as monotherapies, or CT, bupropion SR or buspirone (BuSpar) as ... - Psychiatric Times,
Class-action suit filed against Omnicare Feb 6, 2006
...of Fluoxetine, a generic form of the antidepressant Prozac; and substituting two 7.5 milligram tablets for a single 15 milligram tablet of Buspirone, a generic ... - Louisville Business First,
Omnicare Shares Skid on Downgrade Sparked by Raid Feb 5, 2006
...has been substituting antacid drug Ranitidine capsules for tablets; fluoxetine tablets for capsules; and switching one 15 milligram tablet of Buspirone, an anti ... - ChallengerNKY.com,
Shareholder Class Action Filed Against Omnicare, Inc. by the Law ... Feb 13, 2006
Specifically, that the Company improperly substituted two 7.5-milligram Buspirone anti-anxiety tablets for one 15-milligram tablet, Fluoxetine anti-depression ... - Yahoo! News (press release)
Class-action suit filed against Omnicare Feb 6, 2006
...of Fluoxetine, a generic form of the antidepressant Prozac; and substituting two 7.5 milligram tablets for a single 15 milligram tablet of Buspirone, a generic ... - Louisville Business First,
Omnicare Shares Skid on Downgrade Sparked by Raid Feb 5, 2006
...has been substituting antacid drug Ranitidine capsules for tablets; fluoxetine tablets for capsules; and switching one 15 milligram tablet of Buspirone, an anti ... - ChallengerNKY.com,
Probe News Punishes Omnicare Jan 17, 2006
Specifically, the filing indicates, the government is questioning whether Omnicare improperly substituted two 7.5-milligram Buspirone anti-anxiety tablets for ... - TheStreet.com
Omnicare subpoenaed in generic drug probe Jan 16, 2006
Substituting two 7.5 milligram tablets for a single 15 milligram tablet of Buspirone, a generic form of the anti-anxiety drug BuSpar. ... - Louisville Business First,
Omnicare drug 'relationships' come under federal scrutiny Jan 13, 2006
...substituting two 7.5 mg. tablets of buspirone for a single 15 mg. tablet. Buspirone is used to treat anxiety disorders. After a series of ... - Cincinnati Post,
Comorbid Tobacco Dependence and Psychiatric Disorders Jan 23, 2006
Cinciripini and colleagues (1995) found that smokers with high levels of trait anxiety taking buspirone (BuSpar) versus placebo were more likely to be ... - Psychiatric Times,
Update 1-Omnicare says gets subpoena from US Attorney Jan 13, 2006
Co's (LLY.N: Quote, Profile, Research) antidepressant Prozac; and the substitution of two 7.5 milligram tablets for one 15 mg tablet of Buspirone, a generic of ... - Reuters
Business digest Jan 17, 2006
...are investigating allegations of drug substitutions involving ranitidine (an anti-heartburn medication), fluoxetine (an antidepressant) and buspirone (an anti ... - Cincinnati Enquirer,
City Councilman resigns Jan 12, 2006
...and July 5. Those drugs included hydrocodone, marijuana, OxyContin, Zyrtec 10, buspirone hydrochloride and ranitidine. He also is ... - Myrtle Beach Sun News,
CREATURE FEATURE Dec 7, 2005
The vet has prescribed a drug called buspirone. So far it seems to work. ... Anti-anxiety medications like buspirone often produce instant positive results. ... - Arkansas Democrat-Gazette (subscription),
Woman's 'crime' was never illegal Nov 15, 2005
No one had noticed that a prescription drug found in Isaac's possession, an anti-anxiety medication called Buspirone, is not a controlled substance. ... - Rocky Mountain News,
Possessing drug was not a crime Nov 16, 2005
Prosecutors, the previous defense attorney and even the judge said they were unaware that Buspirone was not a controlled substance, as police alleged when they ... - United Press International
Predix Pharmaceuticals Obtains Special Protocol Assessment for PRX ... Nov 30, 2005
Buspirone is currently the only 5-HT1A agonist approved in the United States for GAD but is generally taken three times a day, requires approximately three ... - Genetic Engineering News,
Oestrogen's role in treating schizophrenia Nov 12, 2005
The normal subjects were given a drug, buspirone, that affects the serotonin 1A receptor) — disrupting their ability to block extraneous noise (mimicking ... - The Age (subscription),
Watercooler Stories Nov 17, 2005
Prosecutors, the previous defense attorney and even the judge said they were unaware that Buspirone was not a controlled substance, as police alleged when they ... - Monsters and Critics.com,
Breaking the Teeth -- Grinding Habit Sep 22, 2005
If you take an SSRI, your doctor may suggest decreasing the dosage or possibly taking the antianxiety drug buspirone (BuSpar, others) in addition to your SSRI. ... - Newswise (press release)
The Exclusion of Benzodiazepine Coverage in Medicare: Simple Steps ... Sep 7, 2005
...the Part D benefit (14) in which benzodiazepine derivatives were removed from the category of suggested covered anticonvulsants, and buspirone and meprobamate ... - Psychiatric Services (subscription)
Worrying all the time? Aug 31, 2005
These include benzodiazepines, buspirone, hydroxyzine, and antidepressants. ... Buspirone (or Buspar) is the only medication in its particular class. ... - Health24.com,
Loris Councilman Herring suspended Aug 31, 2005
...and July 5. Those drugs included hydrocodone, marijuana, OxyContin, Zyrtec 10, buspirone hydrochloride and ranitidine. He also is ... - Myrtle Beach Sun News,
Herring's city seat in danger Aug 30, 2005
July 5. Those drugs included hydrocodone, lorcet, marijuana, OxyContin, Zyrtec 10, buspirone, hydrochloride and ranitidine. He also ... - Myrtle Beach Sun News,
Predix Pharmaceuticals Initiates Phase III Clinical Trial of PRX ... Aug 15, 2005
Buspirone is currently the only 5-HT1A agonist approved in the United States for GAD, but must be taken three times a day, requires approximately three weeks ... - Business Wire (press release),
What Is the Meaning of Football? Aug 3, 2005
Or try Prozac, Zoloft, Seroxat, Aropax, Ativan, Trazolan, Buspirone, Clonazepam, Xanax, Valium, anything that comes with a frickin' prescription. ... - Broward New Times
Womans cause of death undetermined Jul 19, 2005
Although a cause of death remains unknown, Yost said an autopsy and toxicology tests showed Moreira suffered chronic renal failure and buspirone intoxication. ... - Tri-Valley Herald
Treating Alcohol and Drug Abuse: An Evidence Based Review Jul 29, 2005
...brain. Researchers have tried antidepressants, dopamine agonists, anticonvulsants, and buspirone without encouraging results. The ... - Am J Psychiatry (subscription)
Friends try to understand drug arrest Jul 8, 2005
...found was four 40mg OxyContin tablets, one hydrocodone capsule and 187 noncontrolled, prescription medicines (Zyrtec 10, buspirone hydrochloride, ramitidine). ... - Myrtle Beach Sun News
<**results**>
Friends try to understand drug arrest Jul 8, 2005
...found was four 40mg OxyContin tablets, one hydrocodone capsule and 187 noncontrolled, prescription medicines (Zyrtec 10, buspirone hydrochloride, ramitidine). ... - Myrtle Beach Sun News
Psychopharmacology of Autism Spectrum Disorders Jun 20, 2005
Buspirone (BuSpar) has been shown to reduce aggressive symptoms and anxiety in a small group of adults with mental retardation (Ratey et al., 1991). ... - Psychiatric Times
Multi-Modal Integrated Treatment for Youth With Bipolar Disorder Jun 20, 2005
Benzodiazepines (Bernstein et al., 1990; Graae et al., 1994; Simeon et al., 1992) and buspirone (BuSpar) follow as alternative choices. ... - Psychiatric Times,
Other information
Indication
For the management of anxiety disorders or the short-term relief of the symptoms of anxiety
Pharmacology
Buspirone is used in the treatment of generalized anxiety where it has advantages over other antianxiety drugs because it does not cause sedation (drowsiness) and does not cause tolerance or physical dependence. Buspirone differs from typical benzodiazepine anxiolytics in that it does not exert anticonvulsant or muscle relaxant effects. It also lacks the prominent sedative effect that is associated with more typical anxiolytics. in vitro preclinical studies have shown that buspirone has a high affinity for serotonin (5-HT1A) receptors. Buspirone has no significant affinity for benzodiazepine receptors and does not affect GABA binding in vitro or in vivo when tested in preclinical models. Buspirone has moderate affinity for brain D2-dopamine receptors. Some studies do suggest that buspirone may have indirect effects on other neurotransmitter systems.
Mechanism Of Action
Buspirone binds to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus, thus, inhibiting the firing rate of 5-HT-containing neurons in the dorsal raphe. Buspirone also binds at dopamine type 2 (DA2) receptors, blocking presynaptic dopamine receptors. Buspirone increases firing in the locus ceruleus, an area of brain where norepinephrine cell bodies are found in high concentration. The net result of buspirone actions is that serotonergic activity is suppressed while noradrenergic and dopaminergic cell firing is enhanced.
Drug Category
Anti-anxiety Agents; Anxiolytics sedatives and hypnotics; ATC:N05BE01
Brand Names/Synonyms
Ansial; Axoren; B119; B7148; Bespar; Buspar; Buspar Dividose; Buspimen; Buspinol; Buspirona [Inn-Spanish]; Buspirone; Buspirone Hcl; Buspironum [Inn-Latin]; Buspisal; Bustab; CHEMBANK1504; Censpar; Narol; Travin
Dosage Forms
in 5 and 10 mg tablets
Absorption
Rapidly absorbed in man and undergoes extensive first pass metabolism
Interactions
Interactions for Buspirone:
It is recommended that buspirone hydrochloride not be used concomitantly with MAO inhibitors Because the
effects of concomitant administration of buspirone HCl with most other psychotropic drugs have not been studied, the
concomitant use of buspirone HCl with other CNS-active drugs should be approached with caution.
There is one report suggesting that the concomitant use of trazodone hydrochloride (Desyrel) and buspirone HCl may
have caused 3- to 6-fold elevations on SGPT (ALT) in a few patients. In a similar study, attempting to replicate this
finding, no interactive effect on hepatic transaminases was identified.
In a study in normal volunteers, concomitant administration of buspirone HCl and haloperidol resulted in increased
serum haloperidol concentrations. The clinical significance of this finding is not clear.
In vitro, buspirone does not displace tightly bound drugs like phenytoin, propranolol, and warfarin from
serum proteins. However, there has been one report of prolonged prothrombin time when buspirone was added to the
regimen of a patient treated with warfarin. The patient was also chronically receiving phenytoin, phenobarbital,
digoxin, and levothyroxine sodium. In vitro, buspirone may displace less firmly bound drugs like digoxin. The
clinical significance of this property is unknown.
Chemical IUPAC Name
8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione
Chemical Formula
C21H31N5O2
Half Life
2-3 hours
Drug Type
Approved Drug
# Accession No
APRD00222
CAS Registry Number
36505-84-7