Bupivacaine: profile and news

Regulation of Intracellular Calcium by Bupivacaine Isomers in ...  Feb 22, 2006
In this study we investigated the effects of a racemic mixture of bupivacaine (RS(±)bupivacaine) and its isomers (S(-)bupivacaine and R(+)bupivacaine) on the ... - Anesthesia & Analgesia (subscription),

A Randomized Comparison of Programmed Intermittent Epidural Bolus ...  Feb 21, 2006
In this randomized, double-blind study we compared total bupivacaine consumption, need for supplemental epidural analgesia, quality of analgesia, and patient ... - Anesthesia & Analgesia (subscription),

Blurred Vision as the only Symptom of a Positive Epidural Test ...  Feb 21, 2006
Test dose was negative. She was bolused with 10 mL of 0.125% bupivacaine and placed on continuous patient-controlled epidural analgesia. ... - Anesthesia & Analgesia (subscription),

Continuous Epidural Block Versus Continuous Popliteal Nerve Block ...  Feb 21, 2006
After general anesthesia, 0.5 to 1 mL/kg of an equal-volume mixture of 0.25% bupivacaine and 1% lidocaine with 1:200000 epinephrine was injected via epidural ... - Anesthesia & Analgesia (subscription),

DURECT Corporation Reports Fourth Quarter and Year End 2005 ...  Feb 8, 2006
...fiscal year 2005 include the following: -- We achieved positive preliminary data from an 81 patient Phase II study of our SABER-Bupivacaine development product ... - PR Newswire (press release),

Combined Spinal Epidural Causes Higher Level of Block than ...  Feb 14, 2006
All patients intrathecally received 2 mL of 0.5% hyperbaric bupivacaine. The patients were randomized into one of the two groups using sealed opaque envelopes. ... - Anesthesia & Analgesia (subscription),

Pain In Horses  Feb 4, 2006
...potential. The drugs lidocaine, bupivacaine, and mepivacaine are the most commonly used local anesthetics in veterinary medicine today. ... - TheHorse.com,

SkyePharma Issues EGM Notice and Recommends Shareholders to Vote ...  Feb 17, 2006
...formulations of a number of biological products and DepoBupivacaine(TM), a long-acting injectable formulation of the local anaesthetic bupivacaine for the ... - PR Newswire (press release),

DURECT Corporation Reports Fourth Quarter and Year End 2005 ...  Feb 8, 2006
The increases were primarily attributable to the higher development costs related to our SABER-Bupivacaine, Memryte, Remoxy and transdermal patch development ... - PharmaLive.com (press release),

Is the Interscalene Brachial Plexus Block the Best Approach?  Feb 14, 2006
Interscalene brachial plexus block with bupivacaine and ropivacaine in patients with chronic renal failure: diaphragmatic excursion and pulmonary function ... - Anesthesia & Analgesia (subscription),

DURECT to Expand Clinical Program to Additional Surgical ...  Jan 26, 2006
...announced today that it plans to expand its worldwide development program for its post-operative pain relief depot, SABER(TM)-Bupivacaine, by initiating ... - PR Newswire (press release),

The Effects of Local Anesthetics on Bile Flow, Potassium ...  Jan 29, 2006
As it is unknown whether local anesthetics influence liver function, we examined the influence of lidocaine, bupivacaine, and ropivacaine in concentrations of ... - Anesthesia & Analgesia (subscription),

Local Anesthetics Suppress Nerve Growth Factor-Mediated Neurite ...  Jan 29, 2006
We examined the effects of lidocaine, bupivacaine, and procaine on NGF signaling under suppression of NGF-stimulated neurite outgrowth in PC12 cells, which is ... - Anesthesia & Analgesia (subscription),

Pain In Horses  Feb 4, 2006
...potential. The drugs lidocaine, bupivacaine, and mepivacaine are the most commonly used local anesthetics in veterinary medicine today. ... - TheHorse.com,

SkyePharma Announces Appointment of New Chairman and Outcome of ...  Feb 2, 2006
...formulations of a number of biological products and DepoBupivacaine(TM), a long-acting injectable formulation of the local anaesthetic bupivacaine for the ... - PR Newswire (press release),

Epidural Won't Lessen Long-Term Shingles Pain  Jan 19, 2006
...therapy (oral antivirals and analgesics) or standard therapy with one additional injection of steroids (methylprednisolone) plus local anesthetics (bupivacaine ... - Forbes

Shingles, Epidural Injection Does Not Reduce Long-term Pain  Jan 22, 2006
...oral antivirals and analgesics) or standard therapy with one additional epidural injection of steroids (methylprednisolone) and local anaesthetics (bupivacaine ... - Medical News Today (press release),

Perioperative Nimodipine and Postoperative Analgesia  Jan 29, 2006
Spinal anesthesia was induced with hyperbaric bupivacaine 0.5% (2.4–3.0 mL) and fluids and ephedrine were given at the discretion of the anesthesiologist. ... - Anesthesia & Analgesia (subscription),

Epidural Steroid Injection Not Useful for Chronic Shingles Pain  Jan 19, 2006
...oral antivirals and analgesics), and half received standard therapy plus an epidural injection of 80 mg of methylprednisolone acetate and 10 mg of bupivacaine. ... - MedPage Today,

Injection Doesn't end Shingles Pain  Jan 19, 2006
...standard treatment with the oral drugs or standard treatment plus a single injection of the steroid methylprednisolone and the local anesthetic bupivacaine. ... - Ivanhoe,

Can’t Blame Ropivacaine  Sep 30, 2005
I would like to thank Dr. Zeidan for his comments regarding the case we presented (1). The case cited with bupivacaine and fentanyl does indeed show an ... - Anesthesia & Analgesia (subscription),

DURECT Corporation Announces Completion of Dosing in Cohort 3 of ...  Sep 19, 2005
...and final cohort of the Phase II dose escalation study in hernia patients in Australia for DURECT's post-operative pain relief depot, SABER(TM)-Bupivacaine. ... - Yahoo! News (press release)

DURECT to Present Preliminary Phase II Clinical Data for Cohort 3 ...  Sep 21, 2005
...it plans to present preliminary cohort 3 clinical data from its Phase II study for DURECT's post-operative pain relief depot, SABER(TM)-Bupivacaine, during the ... - PR Newswire (press release),

Can’t Blame Ropivacaine  Sep 30, 2005
...exceptionally prolonged anesthesia (36 h) after spinal anesthesia has been reported, but the local anesthetic was an hyperbaric bupivacaine (2). Interestingly ... - Anesthesia & Analgesia (subscription),

The Anticatabolic Effect of Neuraxial Blockade After Hip Surgery  Sep 30, 2005
...surgery received either general anesthesia followed by IV patient-controlled analgesia with piritramide (control; n = 8) or CSE using bupivacaine 0.5% for ... - Anesthesia & Analgesia (subscription),

Plasma Bupivacaine Concentrations Are Too Low to Explain Reduced ...  Aug 22, 2005
...epidural anesthesia decreases the hypnotic, opioid, and muscle relaxant requirement during a general anesthetic with or without bupivacaine injected epidurally ... - Anesthesia & Analgesia (subscription),

Plasma Bupivacaine Concentrations Are Too Low to Explain Reduced ...  Aug 22, 2005
Marked reduction in the requirement of vecuronium in our study could have been the result of either additive or synergistic action of bupivacaine and propofol ... - Anesthesia & Analgesia (subscription),

The Myocardial and Vascular Effects of Bupivacaine ...  Aug 22, 2005
...au. Ropivacaine and levobupivacaine were developed to reduce the risk of fatal accidental overdose reported with bupivacaine. The ... - Anesthesia & Analgesia (subscription),

Determining the Plasma Concentration of Ketamine That Enhances ...  Aug 22, 2005
The plasma concentration of ketamine, an NMDA receptor antagonist that enhances epidural morphine-and-bupivacaine-induced analgesia, is not known. ... - Anesthesia & Analgesia (subscription),

The Effects of Femoral Nerve Blockade in Conjunction with Epidural ...  Aug 22, 2005
Forty-one patients received a single-injection femoral nerve block with 0.375% bupivacaine and 5 µg/mL epinephrine; 39 patients served as controls. ... - Anesthesia & Analgesia (subscription),

Spinal Versus Epidural Anesthesia for Cesarean Delivery in Severe ...  Aug 22, 2005
...morphine after delivery. The spinal group (n = 53) received 2.2 mL of 0.5% hyperbaric bupivacaine plus 0.2 mg morphine. We hypothesized ... - Anesthesia & Analgesia (subscription),

Spinal Anesthesia-Induced Hypotension: A Risk Comparison Between ...  Aug 22, 2005
...n = 65) and parturients with preterm pregnancies (n = 71), undergoing spinal anesthesia for cesarean delivery (0.5% bupivacaine, sufentanil, morphine). ... - Anesthesia & Analgesia (subscription),

Ultrasound-Guided Infraclavicular Versus Supraclavicular Block  Aug 22, 2005
The anesthetic mixture consisted of 0.5 mL/kg of bupivacaine 0.5% and lidocaine hydrocarbonate 2% (1:3 vol.) with epinephrine 1:200,000. ... - Anesthesia & Analgesia (subscription),

Continuous Intra- and Postoperative Thoracic Epidural Analgesia ...  Aug 22, 2005
...undergoing major abdominal surgery received either general anesthesia supplemented with a continuous thoracic epidural infusion of 1.25 mg/mL bupivacaine and 1 ... - Anesthesia & Analgesia (subscription),

Ketamine Sedation During Spinal Anesthesia for Arthroscopic Knee ...  Aug 22, 2005
...divided into two groups. Spinal anesthesia induced with 12.5 mg bupivacaine was administered to all patients. In the ketamine group ... - Anesthesia & Analgesia (subscription),

Reduction in Requirement of Propofol During Combined Epidural ...  Jul 21, 2005
Effect of epidural bupivacaine on induction and maintenance doses of propofol (evaluated by bispectral index) and maintenance doses of fentanyl and vecuronium. ... - Anesthesia & Analgesia (subscription)

The Comparative Neurotoxicity of Intrathecal Lidocaine and ...  Jul 21, 2005
We investigated whether lidocaine and bupivacaine differ with respect to sensory impairment and histologic damage when equipotent doses of the two are ... - Anesthesia & Analgesia (subscription)

The Long Term Myotoxic Effects of Bupivacaine and Ropivacaine ...  Jul 21, 2005
Address e-mail to bernhard_graf{at}med.uni-heidelberg.de. Compared with bupivacaine, acute myotoxicity of ropivacaine is less severe. ... - Anesthesia & Analgesia (subscription)

Improved pain management outcomes with continuous infusion of a ...  Aug 5, 2005
CONCLUSION: A continuous infusion of 0.25% bupivacaine at 4 mL/h through the ON-Q elastomeric infusion pump is a safe and effective adjunct in postoperative ... - The Journal of Thoracic and Cardiovascular Surgery

DURECT Announces Start of Dosing in Cohort 3 of Its Phase II Study ...  Jul 11, 2005
...and final cohort of the Phase II dose escalation study in hernia patients in Australia for DURECT's post-operative pain relief depot, SABER(TM)-Bupivacaine. ... - Yahoo News (press release)

The Short-Lasting Analgesia and Long-Term Antihyperalgesic Effect ...  Jul 21, 2005
Patients were randomized to receive prior to general anesthesia a 2-mL intrathecal (IT) injection of 300 µg of clonidine or saline, or 10 mg of bupivacaine. ... - Anesthesia & Analgesia (subscription)

DURECT Corporation Announces Second Quarter 2005 Financial Results  Jul 22, 2005
We announced exciting preliminary results from cohort 2 of the Phase II study for our post-operative pain relief depot, SABER(TM)-Bupivacaine. ... - Yahoo News (press release)

The Influence of Lumbosacral Cerebrospinal Fluid Volume on Extent ...  Jul 21, 2005
...present study to examine the influence of lumbosacral cerebrospinal fluid (CSF) volume on the spread and duration of hyperbaric bupivacaine spinal anesthesia ... - Anesthesia & Analgesia (subscription)

Intrathecal Morphine for Postpartum Bilateral Tubal Ligation  Jul 21, 2005
In our study, the surgeons provided local anesthetic infiltration before skin incision with 0.5% bupivacaine for a possible preemptive analgesic effect. ... - Anesthesia & Analgesia (subscription)

A Novel Technique for Experimental Stellate Ganglion Block in Rats  Jul 21, 2005
Group I (n = 4) underwent right sided SGB, Group II (n = 5) underwent left-sided SGB, and Group III (n = 5) underwent bilateral SGB using bupivacaine 0.25%. ... - Anesthesia & Analgesia (subscription)

Anesthetic Management Using Echocardiography for Surgery of Lower ...  Jul 21, 2005
After spinal anesthesia was induced with 0.5% bupivacaine (10 mg), the epidural catheter was introduced to the epidural space via the L4-5 space. ... - Anesthesia & Analgesia (subscription)

Nerve Stimulation for Regional Anesthesia of the Face: Use of the ...  Jul 21, 2005
On elicitation of a bilateral blink with 0.5 mA of stimulating current, bupivacaine 0.5% 3–7 mL was injected. Operative conditions were excellent. ... - Anesthesia & Analgesia (subscription)

The administration of local anesthetic solutions containing epinephrine or norepinephrine to patients receiving monoamine oxidase inhibitors or tricyclic antidepressants may produce severe, prolonged hypertension. Concurrent use of these agents should generally be avoided. In situations in which concurrent therapy is necessary, careful patient monitoring is essential.

Concurrent administration of vasopressor drugs and of ergot-type oxytocic drugs may cause severe, persistent hypertension or cerebrovascular accidents.

Phenothiazines and butyrophenones may reduce or reverse the pressor effect of epinephrine.