BuSpar: profile and news






STAR*D Preliminary Findings Provide Clearer Picture of Major ...  Feb 27, 2006
SR), sertraline (Zoloft), venlafaxine XR (Effexor XR) or cognitive therapy (CT) as monotherapies, or CT, bupropion SR or buspirone (BuSpar) as augmenting agents ... - Psychiatric Times,

Class-action suit filed against Omnicare  Feb 6, 2006
...antidepressant Prozac; and substituting two 7.5 milligram tablets for a single 15 milligram tablet of Buspirone, a generic form of the anti-anxiety drug BuSpar ... - Louisville Business First,

Attorney General Announces BuSpar Settlement  Jan 24, 2006
Arkansas and other states reached with Bristol-Myers Squibb after allegations that the company tried to keep generic versions of the drug BuSpar off the market ... - Arkansas Business Online,

Class-action suit filed against Omnicare  Feb 6, 2006
...antidepressant Prozac; and substituting two 7.5 milligram tablets for a single 15 milligram tablet of Buspirone, a generic form of the anti-anxiety drug BuSpar ... - Louisville Business First,

Drug Company Settlement To Help Mental Illness Group  Jan 24, 2006
The settlement stems from allegations that the pharmaceutical company tried to keep generic versions of the anti-anxiety drug BuSpar off the market. ... - Today's THV,

Omnicare subpoenaed in generic drug probe  Jan 16, 2006
Substituting two 7.5 milligram tablets for a single 15 milligram tablet of Buspirone, a generic form of the anti-anxiety drug BuSpar. ... - Louisville Business First,

Update 1-Omnicare says gets subpoena from US Attorney  Jan 13, 2006
Prozac; and the substitution of two 7.5 milligram tablets for one 15 mg tablet of Buspirone, a generic of Bristol-Myers Squibb Co's BuSpar anti-anxiety drug. - Reuters

Bristol-Myers establishes Vanlev fund  Jan 23, 2006
In 2003, the company agreed to settle antitrust suits concerning its methods of blocking generic competitors to its anxiety treatment BuSpar and cancer drug ... - BusinessWeek

Comorbid Tobacco Dependence and Psychiatric Disorders  Jan 23, 2006
Cinciripini and colleagues (1995) found that smokers with high levels of trait anxiety taking buspirone (BuSpar) versus placebo were more likely to be ... - Psychiatric Times,

Extra-marital affairs: are women really to blame? (2)  Nov 14, 2005
Inside the walls of the school, Prozac, Ritalin, Buspar, Celexa are the drugs of choice. He wants to run to the court system for help. ... - Vanguard,

Extra-marital affairs: are women really to blame?  Nov 9, 2005
Outside the walls of school, tomorrow’s men sell and smoke crack. Inside the walls of the school, Prozac, Ritalin, Buspar, Celexa are the drugs of choice. ... - Vanguard,

Anxiety Disorders Discoverable by Blood Test  Oct 10, 2005
Quite often people are diagnosed with general anxiety disorder and are treated with benzos or schedule 5 drugs like BuSpar when in fact they do not have GAD ... - Slashdot

Lexapro and Go Go GO!  Sep 13, 2005
...than depression! We discussed the possibility of adding Buspar to my medication regime, but finally settled for something else. For ... - bipolar.about.com

How to break teeth-grinding habit  Sep 23, 2005
If you take an SSRI, your doctor may suggest decreasing the dosage or possibly taking the antianxiety drug buspirone (BuSpar, others) in addition to your SSRI. ... - myDNA.com,

Doctor faces lawsuit over patient death  Sep 25, 2005
During visits, Alexanderian prescribed Valium, Vicodin, Darvocet, Darvon, Ampicillin, Motrin, Buspar and Soma Tabs with only a few examinations, the suit says. ... - Wilkes Barre Times-Leader,

Worrying all the time?  Aug 31, 2005
...due to subtle cognitive impairment. Buspirone (or Buspar) is the only medication in its particular class. A major advantage of this ... - Health24.com,

Low-Dose Birth Control Pill Treats Severe PMS  Aug 31, 2005
The SSRIs Prozac, Zoloft, and Paxil CR are approved by the FDA for the treatment of PMDD. Other SSRIs used to treat PMDD include Celexa, Effexor, and Buspar. - WebMD

Drug-suit proceeds to benefit Medicaid  Jul 8, 2005
...over the company’s anxiety drug BuSpar. ... The states argued the company’s action had kept BuSpar’s price artificially high, according to the release. ... - Arkansas Democrat-Gazette (subscription)

Drug firm to pay $600,000 to state  Jul 9, 2005
...over the company’s anxiety drug BuSpar. The state Medicaid program, which primarily provides healthcare coverage for the poor, will receive $579,500. ... - Arkansas Democrat-Gazette (subscription)

The Legislated Drugging of the American People  Jul 14, 2005
Prozac, Zoloft, Adderall, Buspar, Wellbutron, Zyban, Paxil, and many, many others - have you noticed the non-stop, televised prime-time advertising of the TMAP ... - SierraTimes.com <**results**>

Drug-suit proceeds to benefit Medicaid  Jul 8, 2005
...over the company’s anxiety drug BuSpar. ... The states argued the company’s action had kept BuSpar’s price artificially high, according to the release. ... - Arkansas Democrat-Gazette (subscription)

Drug firm to pay $600,000 to state  Jul 9, 2005
...over the company’s anxiety drug BuSpar. The state Medicaid program, which primarily provides healthcare coverage for the poor, will receive $579,500. ... - Arkansas Democrat-Gazette (subscription)

Psychopharmacology of Autism Spectrum Disorders  Jun 20, 2005
Buspirone (BuSpar) has been shown to reduce aggressive symptoms and anxiety in a small group of adults with mental retardation (Ratey et al., 1991). ... - Psychiatric Times

Multi-Modal Integrated Treatment for Youth With Bipolar Disorder  Jun 20, 2005
Benzodiazepines (Bernstein et al., 1990; Graae et al., 1994; Simeon et al., 1992) and buspirone (BuSpar) follow as alternative choices. ... - Psychiatric Times,


Other information


Indication
For the management of anxiety disorders or the short-term relief of the symptoms of anxiety

Pharmacology
Buspirone is used in the treatment of generalized anxiety where it has advantages over other antianxiety drugs because it does not cause sedation (drowsiness) and does not cause tolerance or physical dependence. Buspirone differs from typical benzodiazepine anxiolytics in that it does not exert anticonvulsant or muscle relaxant effects. It also lacks the prominent sedative effect that is associated with more typical anxiolytics. in vitro preclinical studies have shown that buspirone has a high affinity for serotonin (5-HT1A) receptors. Buspirone has no significant affinity for benzodiazepine receptors and does not affect GABA binding in vitro or in vivo when tested in preclinical models. Buspirone has moderate affinity for brain D2-dopamine receptors. Some studies do suggest that buspirone may have indirect effects on other neurotransmitter systems.

Mechanism Of Action
Buspirone binds to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus, thus, inhibiting the firing rate of 5-HT-containing neurons in the dorsal raphe. Buspirone also binds at dopamine type 2 (DA2) receptors, blocking presynaptic dopamine receptors. Buspirone increases firing in the locus ceruleus, an area of brain where norepinephrine cell bodies are found in high concentration. The net result of buspirone actions is that serotonergic activity is suppressed while noradrenergic and dopaminergic cell firing is enhanced.

Drug Category
Anti-anxiety Agents; Anxiolytics sedatives and hypnotics; ATC:N05BE01

Brand Names/Synonyms
Ansial; Axoren; B119; B7148; Bespar; Buspar; Buspar Dividose; Buspimen; Buspinol; Buspirona [Inn-Spanish]; Buspirone; Buspirone Hcl; Buspironum [Inn-Latin]; Buspisal; Bustab; CHEMBANK1504; Censpar; Narol; Travin

Dosage Forms
in 5 and 10 mg tablets

Absorption
Rapidly absorbed in man and undergoes extensive first pass metabolism

Interactions
Interactions for Buspirone:

It is recommended that buspirone hydrochloride not be used concomitantly with MAO inhibitors Because the effects of concomitant administration of buspirone HCl with most other psychotropic drugs have not been studied, the concomitant use of buspirone HCl with other CNS-active drugs should be approached with caution.

There is one report suggesting that the concomitant use of trazodone hydrochloride (Desyrel) and buspirone HCl may have caused 3- to 6-fold elevations on SGPT (ALT) in a few patients. In a similar study, attempting to replicate this finding, no interactive effect on hepatic transaminases was identified.

In a study in normal volunteers, concomitant administration of buspirone HCl and haloperidol resulted in increased serum haloperidol concentrations. The clinical significance of this finding is not clear.

In vitro, buspirone does not displace tightly bound drugs like phenytoin, propranolol, and warfarin from serum proteins. However, there has been one report of prolonged prothrombin time when buspirone was added to the regimen of a patient treated with warfarin. The patient was also chronically receiving phenytoin, phenobarbital, digoxin, and levothyroxine sodium. In vitro, buspirone may displace less firmly bound drugs like digoxin. The clinical significance of this property is unknown.



Chemical IUPAC Name
8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione

Chemical Formula
C21H31N5O2

Half Life
2-3 hours

Drug Type
Approved Drug

# Accession No
APRD00222

CAS Registry Number
36505-84-7

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