Brevital: profile and news

Mother Can Sue Abortion Business Over Daughter's Abortion Death Jun 10, 2005
According to court records, Bell was given 150 milligrams (mg) of Brevital as an induction dose and three subsequent maintenance doses of 100 mg, 100 mg, and ... - LifeNews.com,

Other information

Indication
Indicated for use as an intravenous anaesthetic.

Pharmacology
Methohexital, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation.

Mechanism Of Action
Methohexital binds at a distinct binding site associated with a Cl^- ionopore at the GABA_A receptor, increasing the duration of time for which the Cl^- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

Drug Category
Anesthetics; Barbiturates; ATC:N01AF01; ATC:N05CA15

Brand Names/Synonyms
Brevital; Brevital Sodium; Brietal; Methodrexitone; Methohexital; Methohexitone

Dosage Forms
POWDER FOR SOLUTION

Absorption
The absolute bioavailability of rectal methohexital sodium is 17%.

Interactions
-->Interactions for Methohexital:

Prior chronic administration of barbiturates or phenytoin (e.g. for seizure disorder) appears to reduce the effectiveness of Brevital Sodium. Barbiturates may influence the metabolism of other concomitantly used drugs, such as phentyoin, halothane, anticoagulants, corticosteroids, ethyl alcohol, and propylene glycol-containing solutions.

Chemical IUPAC Name
1-methyl-5-(1-methylpent-2-ynyl)-5-prop-2-enyl-hexahydropyrimidine-2,4,6-trione

Chemical Formula
C14H18N2O3

Half Life
5.6 ą 2.7 minutes

Drug Type
Approved Drug

# Accession No
APRD00058

CAS Registry Number
151-83-7