Bicillin: profile and news

Back from boot camp, Marine relishes comforts of home Nov 21, 2005
The shot was a form of penicillin called bicillin. The exercise from the hike helps spread the serum through a recruit's system ... - Brunswick Times Record,

Zithromax Equivalent to Bicillin LA in Treating Syphilis Sep 21, 2005
...issue of the New England Journal of Medicine, compared a 2 g oral dose of Zithromax with a 2.4 million unit intramuscular injection of Bicillin LA (penicillin ... - MedPage Today,

Zithromax Equivalent to Bicillin LA in Treating Syphilis Sep 22, 2005
MBEYA, Tanzania, Sept. 21-A single dose of the oral antibiotic Zithromax is as effective as a standard intramuscular injection of ... - Borsa-Italia.Net,

Azithromycin versus Penicillin G Benzathine for Early Syphilis Sep 24, 2005
Penicillin G benzathine is now marketed in the United States as Bicillin LA (not to be confused with Bicillin CR, a combination of penicillin G benzathine and ... - New England Journal of Medicine (subscription),

Lyme disease symptoms still affect local resident Sep 25, 2005
...the PICC line dressing.". She's also had more than 200 bicillin shots, which are approximately $50 each. The main symptoms she's ... - Keyser Mineral Daily News Tribune,

Inadvertent Use of Bicillin ® CR to Treat Syphilis Infection ... Apr 26, 2005
The clinic had inadvertently used Bicillin ® CR, a mixture of 1.2 million units (MU) benzathine penicillin G (BPG) and 1.2 MU procaine penicillin G, rather ... - Journal of American Medical Association (subscription)

The Rest of Our World Apr 11, 2005
The clinic used Bicillin CR, rather than Bicillin LA. Bicillin ... streptococci. The efficacy of Bicillin CR in treating syphilis is unknown. ... - Richmond Out in the Mountains,

Inadvertent Use of Bicillin® CR to Treat Syphilis Infection - Los ... Mar 11, 2005
The clinic had inadvertently used Bicillin® CR, a mixture of 1.2 million units (MU) benzathine penicillin G (BPG) and 1.2 MU procaine penicillin G, rather ... - Medical News Today,

WRONG PENICILLIN GIVEN TO 650 LA PATIENTS FOR SYPHILIS Mar 13, 2005
...of syphilis. The figure of the deaths is an expected number. The Gay & Lesbian Center had administered Bicillin CR. but that formulation ... - Express Newsline,

LA gay center dispensed wrong syphilis medication Mar 14, 2005
There are several different formulas of penicillin, health authorities say, and the medication that was dispensed--Bicillin CR--contains only half the dose the ... - The Advocate,

More Patients Got Wrong Syphilis Medication at Gay Center, CDC ... Mar 11, 2005
Clients at the Center got Bicillin CR instead of Bicillin LA, the trade name for benzathine penicillin G. Bicillin CR contains only ... - Los Angeles Times (subscription),

GAY CENTER GIVES WRONG PENICILLIN TO 650 PATIENTS Mar 14, 2005
The Gay and Lesbian Center had administered Bicillin CR but that formulation has not been recommended to treat syphilis, according to the study, which was ... - Out In America,

Los Angeles Clinic Used Wrong Drug for Syphilis Mar 10, 2005
The recommended drug, Bicillin LA, contains 2.4 million units (MU) of benzathine penicillin G. The preparation that was used by mistake, Bicillin CR, contains ... - Reuters

Gay clinic gave wrong syphilis meds Mar 11, 2005
But in a joint report with the Centers of Disease Control and Prevention (CDC), the center said 663 patients at the Center got Bicillin CR, which contains only ... - PlanetOut,

Feds: Wrong penicillin given to 650 LA patients for syphilis Mar 11, 2005
The Gay & Lesbian Center had administered Bicillin CR but that formulation is not intended to treat syphilis, federal officials said. ... - San Jose Mercury News

Health News Briefs Mar 11, 2005
The clinic prescribed a drug called Bicillin CR when it should have used Bicillin LA. That meant patients with syphilis got half the proper dose of penicillin. ... - NPR,

WRONG PENICILLIN GIVEN TO 650 LA PATIENTS FOR SYPHILIS 14 Mar 2005
...of syphilis. The figure of the deaths is an expected number. The Gay & Lesbian Center had administered Bicillin CR. but that formulation ... - Express Newsline,

Other information

Indication
Infections (penicillin sensitive when extended)

Pharmacology
Penicillin G is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Penicillin G has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Penicillin G results from the inhibition of cell wall synthesis and is mediated through Penicillin G binding to penicillin binding proteins (PBPs). Penicillin G is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.

Mechanism Of Action
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Penicillin G inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Penicillin G interferes with an autolysin inhibitor.

Drug Category
Anti-bacterial Agents; Penicillins; ATC:J01CE01

Brand Names/Synonyms
Abbocillin; Ayercillin; Benzopenicillin; Benzylpenicillin; Benzylpenicillin G; Benzylpenicillinic Acid; Bicillin; Bicillin L-A; Cillora; Cilloral; Cilopen; Compocillin G; Cosmopen; Crysticillin 300 A.S.; Dropcillin; Duracillin A.S.; Free Benzylpenicillin; Free Penicillin G; Free Penicillin Ii; Galofak; Gelacillin; Liquacillin; Megacillin; Pencillin G; Penicillin; Penicillin G; Penicillin G Potassium; Penicillin G Potassium in Plastic Container; Penicillin G Procaine; Penicillin G Sodium; Penicillin-G Potassium; Penicillinic Acid, Benzyl-; Pentids; Pentids '200'; Permapen; Pfizerpen; Pfizerpen G; Pfizerpen-As; Pharmacillin; Phenylacetamidopenicillanic Acid; Pradupen; Specilline G; Ursopen; Wycillin

Dosage Forms
SUSPENSION

Absorption
Not Available

Interactions
Drug Interactions for Penicillin G:

Concurrent administration of bacteriostatic antibiotics (e.g., erythromycin, tetracycline) may diminish the bactericidal effects of penicillins by slowing the rate of bacterial growth. Bactericidal agents work most effectively against the immature cell wall of rapidly proliferating microorganisms. This has been demonstrated in vitro; however, the clinical significance of this interaction is not well documented. There are few clinical situations in which the concurrent use of ''static'' and ''cidal '' antibiotics are indicated. However, in selected circumstances in which such therapy is appropriate, using adequate doses of antibacterial agents and beginning penicillin therapy first, should minimize the potential for interaction.

Penicillin blood levels may be prolonged by concurrent administration of probenecid which blocks the renal tubular secretion of penicillins.

Displacement of penicillin from plasma protein binding sites will elevate the level of free penicillin in the serum.

Chemical IUPAC Name
3,3-dimethyl-6-oxo-7-(2-phenylacetyl)amino-2-thia-5-azabicyclo[3.2.0]heptane-4-carboxylicacid

Chemical Formula
C16H18N2O4S

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00646

CAS Registry Number
61-33-6