Betamethasone: profile and news

Topical therapies show promise for Psoriasis 06 Mar 2006
A combination of calcipotriene and betamethasone dipropionate, a vitamin D analogue and a potent corticosteroid, was recently approved by the FDA in an ... - News-Medical.net,

Betamethasone Affects Cerebral Expressions of NF- B and Cytokines ... Feb 24, 2006
The effects of topical betamethasone on neuropathic pain and cerebral expression of NF- B and cytokines were studied in a rat model of L5 spinal nerve ... - Annals of Clinical & Laboratory Science,

Harper’s Findings Mar 5, 2006
It was discovered that betamethasone, a synthetic glucocorticoid drug given to mothers who are at risk of giving birth prematurely, can cause harmful side ... - Arkansas Democrat-Gazette (subscription),

TODAY ON PHARMALIVE.COM Mar 3, 2006
...foam drug delivery vehicle VersaFoam(R). The Company's marketed products are OLUX(R) (clobetasol propionate) Foam, 0.05%, Luxiq(R) (betamethasone valerate) Foam ... - PharmaLive.com (press release),

President leaves PediaMed after sales force sold Feb 27, 2006
...said the PediaMed group would begin selling Evoclin (clindamycin) Foam, 1 percent, a topical treatment for acne, and Luxiq (betamethasone valerate) Foam, 0.12 ... - Cincinnati Business Courier,

Kav's Undoubtedly last but not least Feb 5, 2006
Play To Win) and Joe Hall (Chicago Sun) will attend similar inquiries after their respective horses returned positive swabs to the pain-killer Betamethasone. - Advertiser Adelaide,

Riders finally to receive medals Feb 5, 2006
Beerbaum appealed that the banned substance Betamethasone, an anti-inflammatory drug, was in an ointment used for a skin irritation on the horse. ... - Sun-Sentinel.com,

America awarded Olympic gold Feb 6, 2006
...a test for prohibited substances immediately after the Athens competition and subsequent tests tested positive to the anti-inflammatory drug betamethasone. ... - Horse & Hound Online,

Prices of 112 formulations reduced Feb 1, 2006
...killer), chloroquine (anti-malarial), cloxacillin (antibiotic), theophylline & salbutamol (respiratory drugs), betamethasone (corticosteriods), sulphamethaxole ... - Financial Express,

NPPA Fixes/Revises Prices Of Bulk Drugs And Formulations Feb 1, 2006
Killer), Chloroquine (Anti-Malarial), Cloxacillin (Antibiotic), Theophylline & Salbutamol (Respiratory Drugs), Betamethasone (Corticosteriods), Sulphamethaxole ... - Indlaw.com,

NPPA reduces prices of 112 formulations Feb 1, 2006
...of derivative formulations of the bulk drugs namely, Ibuprofen, Chloroquine, Cloxacillin, Theophylline & Salbutamol, Betamethasone, Sulphamethaxole, Pyrantal ... - India Infoline.com,

Taro Receives Tentative Approval for Augmented Betamethasone ... Jan 26, 2006
...has received tentative approval from the US Food and Drug Administration ("FDA") for its Abbreviated New Drug Application for Betamethasone Dipropionate Lotion ... - Genetic Engineering News,

FDA Approves Taclonex (Calcipotriene/Betamethasone Dipropionate) ... Jan 10, 2006
Taclonex is a topical ointment containing a combination of calcipotriene 0.005% and betamethasone dipropionate 0.064% for the treatment of psoriasis vulgaris ... - DG News

Connetics Names Freddie Park Vice President, Intellectual Property ... Feb 6, 2006
...foam drug delivery vehicle VersaFoam(R). The Company's marketed products are OLUX(R) (clobetasol propionate) Foam, 0.05%, Luxiq(R) (betamethasone valerate) Foam ... - Genetic Engineering News,

Taro tentatively OK'd for Diprolene Jan 26, 2006
The company said the Food and Drug Administration approved Taro's generic version of Schering's augmented betamethasone dipropionate lotion, 0.05 percent. ... - United Press International

Hayes keeps nine options for Blue Diamond Jan 31, 2006
Kavanagh's galloper Play To Win returned a swab containing the substance Betamethasone after racing at Cheltenham on December 10. - The Age,

Connetics Acquires PediaMed Sales Organization; Enters Pediatric ... Jan 10, 2006
...in early February, the group will begin selling Evoclin(TM) (clindamycin) Foam, 1%, a topical treatment for acne, and Luxiq(R) (betamethasone valerate) Foam ... - Genetic Engineering News,

Burbs: Atlas Air CEO to step down Jan 31, 2006
...of Hawthorne has received tentative approval from the US Food and Drug Administration for its new drug application for Betamethasone Dipropionate Lotion. ... - The Journal News.com,

FDA Approves Taclonex(R) - Once Daily Therapy for Treatment of ... Jan 10, 2006
Taclonex(R) is a topical ointment containing a combination of calcipotriene 0.005% and betamethasone dipropionate 0.064% for the treatment of psoriasis ... - PR Newswire (press release),

Pregnancy drugs can affect grandkids Nov 30, 2005
...the 1970s, doctors have been injecting women at risk of having a very premature baby with synthetic glucocorticoid drugs, such as betamethasone, which hasten ... - EurekAlert (press release),

Concern over pregnancy drug Nov 30, 2005
Since the 1970s synthetic glucocorticoid drugs, such as betamethasone, have been used to speed the development of premature babies' lungs. ... - Daily Mail - UK,

Warner Chilcott Reports Results for the Quarter and Nine Months ... Nov 11, 2005
...said "On July 1st we realigned our sales forces in anticipation of the expected launch of DOVOBET(R) (calcipotriol / betamethasone dipropionate) for psoriasis. ... - PR Newswire (press release),

Connetics Names Srabasti Mukherjee Associate Director, Business ... Nov 10, 2005
...foam drug delivery vehicle VersaFoam(R). The Company's marketed products are OLUX(R) (clobetasol propionate) Foam, 0.05%, Luxiq(R) (betamethasone valerate) Foam ... - PharmaLive.com (press release),

Investigational Psoriasis Therapy May Represent an Effective New ... Oct 25, 2005
25 /PRNewswire-FirstCall/ -- Researchers reported today that the investigational topical combination therapy calcipotriene/betamethasone dipropionate may ... - PR Newswire (press release),

Investigational Psoriasis Therapy May Represent an Effective New ... Oct 26, 2005
ROCKAWAY, NJ -- October 26, 2005 -- Researchers reported that the investigational topical combination therapy calcipotriene/betamethasone dipropionate may ... - DG News

Neonatal Morbidity and Growth in Very Low Birth-Weight Infants ... Oct 26, 2005
Vermillion ST, Soper DE, Chasedunn-Roark J. Neonatal sepsis after betamethasone administration to patients with preterm premature rupture of membranes. ... - Nature.com (subscription),

Drugs and Competition Oct 23, 2005
Steroids (corticosteroids)--These include drugs such as dexamethasone, methylprednisolone, betamethasone, etc., are allowed when administered for a therapeutic ... - TheHorse.com,

Connetics Founder Eugene A. Bauer Steps Down as Director after 11 ... Oct 17, 2005
...foam drug delivery vehicle VersaFoam(R). The Company's marketed products are OLUX(R) (clobetasol propionate) Foam, 0.05%, Luxiq(R) (betamethasone valerate) Foam ... - Genetic Engineering News,

Rockingham Memorial Hospital Oct 16, 2005
I also use a soluble steroid (betamethasone [Celestone], Schering-Plough Corp, Kenilworth, NJ) for all cervical injections and place the needle outside the ... - Am J Neuroradiology (subscription)

Enters into co-promotion agreement with Bristol-Myers Squibb for ... Oct 3, 2005
...a Development Agreement with LEO Pharma to develop Dovobet®, LEO Pharma’s combination product containing calcipotriene and betamethasone dipropionate, for ... - Biotechnology Investment Today (Press Release),

Connetics Launches AcneMedicine.com; A New Online Resource to Help ... 11 Oct 2005
...foam drug delivery vehicle VersaFoam(R). The Company's marketed products are OLUX(R) (clobetasol propionate) Foam, 0.05%, Luxiq(R) (betamethasone valerate) Foam ... - Genetic Engineering News,

Two-Drug Topical Treatment Effective in Early Mycosis Fungoides Sep 28, 2005
Study Group of Cutaneous Lymphomas examined the effects of twice-weekly application of mechlorethamine hydrochloride and betamethasone dipropionate cream in 63 ... - Cancerpage.com,

FIXATION/REVISION OF PRICES OF BULK DRUGS UNDER DPCO, 1995. Sep 19, 2005
The prices of bulk drugs Betamethasone Alcohol, Betamethasone Valerate and Betamethasone Di-Sodium Phosphate has been revised down ward from Rs.221/gm., Rs.210 ... - Press Information Bureau (press release),

NPPA revises 16 bulk drug prices Sep 19, 2005
The prices of bulk drugs Betamethasone Alcohol, Betamethasone Valerate and Betamethasone Di-Sodium Phosphate has been revised down ward from Rs221per gram ... - India Infoline.com,

NPPA cuts prices of asthma, anti-inflammatory drugs Sep 19, 2005
The prices of bulk drugs used for inflammation, betamethasone alcohol, betamethasone valerate and betamethasone di-sodium phosphate has also been revised ... - Hindu Business Line,

NPPA revises 16 bulk drug prices Sep 20, 2005
Betamethasone alcohol, betamethasone valerate and betamethasone di-sodium phosphate has been cut from Rs 221 per gm., Rs210 per gm and Rs176 per gm to Rs220 ... - domain-B,

Foamix Commences Phase II Study of TerbiFoam(TM) 2% Foam for the ... Sep 12, 2005
Company Concurrently Conducts Phase II Study of Betamethasone 0.12% Emollient Foam for the Treatment of Psoriasis NESS ZIONA, Israel, September 12 /PRNewswire ... - PR Newswire (press release),

Foamix to commence Phase II clinical trial of athlete’s foot ... Sep 12, 2005
It was also announced today that Foamix is concurrently conducting a controlled Phase II clinical trial of its proprietary betamethasone 0.12% emollient foam ... - Globes,

Foamix Commences Phase II Study of TerbiFoam 2% Foam for the ... Sep 12, 2005
It was also announced today that Foamix is concurrently conducting a controlled Phase II clinical trial of its proprietary Betamethasone 0.12% Emollient Foam ... - PharmaLive.com (press release),

Alliance aims at foam-based treatment for scabies Sep 22, 2005
Most foam dosage forms used in dermatology to date have incorporated corticosteroids, notably Connetics' Luxiq (betamethasone) formulation for scalp psoriasis ... - in-PharmaTechnologist,

NPPA FIXES/REVISES THE PRICES OF 308 FORMULATION PACKS Sep 19, 2005
It also includes 81 cases of Betamethasone Dipropionate and certain others formulations, formulated namely by M/s. Cipla, Sun Pharma, Wockhardt, Alkem and USV ... - Press Information Bureau (press release),

Foamix begins phase II athlete's foot trial Sep 13, 2005
The company has also announced that it is concurrently conducting a controlled phase II clinical trial of its proprietary betamethasone 0.12% emollient foam ... - Pharmaceutical Business Review

Other information

Indication
For relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses

Pharmacology
Betamethasone and its derivatives, betamethasone sodium phosphate and betamethasone acetate, are synthetic glucocorticoids. Used for its antiinflammatory or immunosuppressive properties, betamethasone is combined with a mineralocorticoid to manage adrenal insufficiency and is used in the form of betamethasone benzoate, betamethasone dipropionate, or betamethasone valerate for the treatment of inflammation due to corticosteroid-responsive dermatoses. Betamethasone and clotrimazole are used together to treat cutaneous tinea infections.

Mechanism Of Action
Betamethasone is a glucocorticoid Receptor Agonist. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Betamethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin.

Drug Category
Corticosteroid; Glucocorticoids; Anti-inflammatory, steroidal; Immunosuppressant; ATC:A07EA04; ATC:C05AA05; ATC:D07AC01; ATC:D07XC01; ATC:H02AB01; ATC:R01AD06; ATC:R03BA04; ATC:S01BA06; ATC:S01CB04; ATC:S02BA07; ATC:S03BA03

Brand Names/Synonyms
Alphatrex; Bebate; Becort; Bedifos; Beta-Methasone; Beta-Methasone Alcohol; Beta-Val; Betacorlan; Betacortril; Betaderm; Betadexamethasone; Betafluorene; Betamamallet; Betametasona [Inn-Spanish]; Betametasone [Dcit]; Betamethasone; Betamethasone Alcohol; Betamethasone Base; Betamethasone Cream; Betamethasone Dipropionate; Betamethasone Sodium Phosphate; Betamethasone Valearate; Betamethasone Valerate; Betamethasone [Usan:Ban:Inn:Jan]; Betamethasonum [Inn-Latin]; Betamethasonvalerat Mikron.; Betamethazone; Betapredol; Betasolon; Betatrex; Betnelan; Betsolan; Celestene; Celestone; Celestone Syrup and Tablets; Cidoten; Dermabet; Desacort-Beta; Diproderm; Diprolene; Diprolene Af; Diprosone; Flubenisolone; HSDB 3015; Hormezon; Lotrisone; Luxiq; Luxiqo; Maxivate; Methazon; Rinderon; Rinderon A; Sch 4831; Uticort; Valisone; Valnac; Visubeta

Dosage Forms
Syrup; Tablet

Absorption
Minimal if applied topically

Interactions
Interactions for Betamethasone:
APRD00513_IN,txt

Chemical IUPAC Name
9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

Chemical Formula
C22H29FO5

Half Life
5.6 hours

Drug Type
Approved Drug

# Accession No
APRD00513

CAS Registry Number
378-44-9