Benzonatate: profile and news

COUGHING: Causes & cures Mar 5, 2006
Even at normal doses, they can cause you to feel bad all over, like the flu only not quite as bad.". The second is benzonatate. It ... - Charlotte Observer,

Been coughing? That's not necessarily a bad thing Feb 28, 2006
..."A narcotic can be addictive," he says. "And if you take a lot of it, narcotics can cause respiratory depression.". The second is benzonatate. ... - Detroit Free Press,

Other information

Indication
For the symptomatic relief of cough

Pharmacology
Benzonatate, a non-narcotic antitussive agent chemically related to tetracaine and other ester-type local anesthetics, is used to suppress cough associated with both acute and chronic respiratory conditions.

Mechanism Of Action
Benzonatate acts peripherally, anesthetizing the stretch receptors of vagal afferent fibers in the alveoli of the lungs, bronchi, and pleura. When applied locally, Benzonatate binds within the intracellular portion of voltage-gated sodium channels, decreasing the rate of membrane depolarization and increasing the threshold for electrical excitability.

Drug Category
Antitussives; ATC:R05DB01

Brand Names/Synonyms
Benzonatate; Benzonatate [Usan:Ban:Inn]; Benzonatato [Inn-Spanish]; Benzonatatum [Inn-Latin]; Benzononantin; Benzononatine; Exangit; KM65; Tesalon; Tessalin; Tessalon; Tessalon Perles; Tessalon-Ciba; Ventussin; Ventussin-Loz

Dosage Forms
soft gelatin capsule containing 100mg benzonatate

Absorption
Not Available

Interactions
Interactions for Benzonatate:

No information provided.

Chemical IUPAC Name
2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl4-butylaminobenzoate

Chemical Formula
C30H53NO11

Half Life
3- 8 hours

Drug Type
Approved Drug

# Accession No
APRD00629

CAS Registry Number
104-31-4