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Bendroflumethiazide: profile and news
King Pharmaceuticals Reports Year-End and Fourth-Quarter 2005 ... Feb 28, 2006 Other information Indication For the treatment of high blood pressure and management of edema Pharmacology Bendroflumethiazide, a thiazide diuretic, removes excess water from the body by increasing how often you urinate (pass water) and also widens the blood vessels which helps to reduce blood pressure. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue. Mechanism Of Action As a diuretic, bendroflumethiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like bendroflumethiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of bendroflumethiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle. Drug Category Diuretics, Thiazide; Antihypertensive Agents; ATC:C03AA01 Brand Names/Synonyms Aprinox; BHFT; BL H368; Bendrofluazide; Bendroflumethazide; Bendroflumethiazide; Bendroflumethiazide [Inn]; Bendroflumethiazidum [Inn-Latin]; Bendroflumetiazida [Inn-Spanish]; Bendroflumetiazide [Dcit]; Bendrofumethiazide; Bentride; Benuron; Benzhydroflumethiazide; Benzy-Rodiuran; Benzydroflumethiazide; Benzylhydroflumethiazide; Benzylrodiuran; Berkozide; Bhft; Bristuric; Bristuron; CHEMBANK917; Centyl; Corzide; FT 8; FT 81; Flumersil; Flumesil; HSDB 3293; Intolex; Livesan; Naigaril; Nateretin; Naturetin; Naturetin-2.5; Naturine; Neo-Naclex; Neo-Rontyl; Niagaril; Nikion; Orsile; Pluryl; Pluryle; Plusuril; Poliuron; Rautrax N; Rauzide; Relan Beta; Repicin; Salural; Salures; Sinesalin; Sodiuretic; Thiazidico; Urlea Dosage Forms TABLET Absorption Absorbed relatively rapidly after oral administration Interactions Interactions for Bendroflumethiazide: May interact with the following: cholestyramine, colestipol (use with thiazide diuretics may prevent the diuretic from working properly; take the diuretic at least 1 hour before or 4 hours after cholestyramine or colestipol), digitalis glycosides (use with thiazide diuretics may cause high blood levels of digoxin, which may increase the chance of side effects), and lithium (use with thiazide diuretics may cause high blood levels of lithium, which may increase the chance of side effects). Chemical IUPAC Name 3-benzyl-5,5-dioxo-9-(trifluoromethyl)-5$l^{6}-thia-2,4-diazabicyclo[4.4.0]deca-7,9,11-triene-8-sulfonamide Chemical Formula C15H14F3N3O4S2 Half Life 8.5 hours Drug Type Approved Drug # Accession No APRD00666 CAS Registry Number 73-48-3 |
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