Beconase_AQ: profile and news

Rigel Announces Disappointing Results from Phase II Study of R112 ... Dec 1, 2005
The randomized, double-blind study compared R112 and Beconase AQ(R) (beclomethasone) nasal spray to placebo, over a 7-day period. ... - PR Newswire (press release),

Poor drug trial trips Rigel Pharma Dec 1, 2005
The same trial also showed another allergy drug, Beconase AQ, was effective when compared to a placebo in treating allergy symptoms. ... - MarketWatch

Drugs stocks climb while Rigel dives on drug data Dec 1, 2005
The same trial showed that another drug, Beconase AQ, was effective. ... Rigel's bad news appeared to give a boost to GlaxoSmithKline, which markets Beconase AQ. ... - Investor's Business Daily (subscription)

UPDATE 1-Rigel hay fever treatment fails in clinical trial Dec 1, 2005
In the phase II trial, a randomized, double-blind study over seven days, a rival treatment, Beconase AQ nasal spray, demonstrated superior results relative to ... - Reuters

UPDATE 2-Rigel hay fever treatment fails in clinical trial Dec 1, 2005
Phase II trial. But a rival treatment, Beconase AQ nasal spray, proved superior to placebo in the seven-day study. Rigel Chief Executive ... - Reuters

Poor drug trial trips Rigel Pharma Dec 1, 2005
...allergy symptoms. , , ) , over a 7-day period. Beconase AQ was found to be superior to the placebo treatment in the trial. "We are ... - MarketWatch

Health Stocks in Motion Dec 1, 2005
...phase II 'Park' study of R112 demonstrated a statistically significant reduction in the symptoms associated with the allergies." Beconase AQ, a GlaxoSmithKline ... - TheStreet.com

Rigel, Serono Enter $160M Aurora Kinase Inhibitor Deal Oct 25, 2005
In August, the company enrolled the first patient in a 375-patient study comparing the compound with placebo and Beconase AQ (beclomethasone) nasal spray over ... - BioWorld Online (subscription),

Comparative Phase II Clinical Trial of R112 for Allergy Treatment Aug 10, 2005
...which is expected to enroll approximately 375 patients, will be a randomized, double-blind study comparing R112 to placebo and Beconase AQ(R) (beclomethasone ... - Medical News Today (press release),

Health Northwest: Dealing with springtime allergies Mar 25, 2005
Prescription nasal corticosteroid sprays include beclomethasone (Beconase AQ), fluticasone (Flonase) and budesonide (Rhinocort). ... - The Daily Astorian (subscription),

Other information

Indication
For the maintenance treatment of asthma as prophylactic therapy in patients 5 years of age and older

Pharmacology
Beclomethasone, a synthetic halogenated glucocorticoid with antiinflammatory and vasoconstrictive effects, is used for treating steroid-dependent asthma, allergic or nonallergic rhinitis, or recurrent nasal polyps.

Mechanism Of Action
Unbound corticosteroids cross cell membranes and bind with high affinity to specific cytoplasmic receptors. The result includes inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

Drug Category
Antiarrhythmic Agents; Glucocorticoids; Anti-inflammatory Agents; Corticosteroids; ATC:A07EA07; ATC:D07AC15; ATC:R01AD01; ATC:R03BA01

Brand Names/Synonyms
Aerobec; Aldecin; Anceron; Andion; Beclacin; Becloforte; Beclomet; Beclometasona [Inn-Spanish]; Beclometasondipropionat Mikron; Beclometasondipropionat Mikron.; Beclometasone; Beclometasonum [Inn-Latin]; Beclomethasone; Beclorhinol; Becloval; Beclovent; Becodisks; Beconase; Beconase Aq; Beconasol; Becotide; Clenil-A; Entyderma; Inalone; Korbutone; Propaderm; Qvar; Qvar 80; Rino-Clenil; Sanasthmax; Sanasthmyl; Vancenase; Vancenase Aq; Vanceril; Vanceril Double Strength; Viarex; Viarox

Dosage Forms
Oral inhalation; Nasal inhalation; Nasal Spray

Absorption
mean peak plasma concentration was 88pg/ml at 0.5 hour

Interactions
Interactions for Beclomethasone:
Albuterol, Antihistamines, antidiabetic drugs, diuretics, digitalis.

Chemical IUPAC Name
[9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-propanoyloxyacetyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate

Chemical Formula
C28H37ClO7

Half Life
2.8 hours

Drug Type
Approved Drug

# Accession No
APRD00564

CAS Registry Number
4419-39-0