Beconase: profile and news






Rigel Announces Disappointing Results from Phase II Study of R112 ...  Dec 1, 2005
The randomized, double-blind study compared R112 and Beconase AQ(R) (beclomethasone) nasal spray to placebo, over a 7-day period. ... - PR Newswire (press release),

Poor drug trial trips Rigel Pharma  Dec 1, 2005
The same trial also showed another allergy drug, Beconase AQ, was effective when compared to a placebo in treating allergy symptoms. ... - MarketWatch

Rigel allergy drug fades in Phase 2 trial  Dec 1, 2005
Rigel said its potential treatment, which was pitted against GlaxoSmithKline's Beconase nasal spray, failed to show a statistically significant difference from ... - United Press International

About this Author  Dec 1, 2005
They ran about 400 patients through a seven-day course of either their inhaled drug, a placebo, or Beconase, an inhaled steroid from GSK. ... - Corante

UPDATE 1-Rigel hay fever treatment fails in clinical trial  Dec 1, 2005
In the phase II trial, a randomized, double-blind study over seven days, a rival treatment, Beconase AQ nasal spray, demonstrated superior results relative to ... - Reuters

UPDATE 2-Rigel hay fever treatment fails in clinical trial  Dec 1, 2005
Phase II trial. But a rival treatment, Beconase AQ nasal spray, proved superior to placebo in the seven-day study. Rigel Chief Executive ... - Reuters

Rigel down on disappointing allergy drug study  Dec 1, 2005
...symptoms. In the same seven-day study, the GlaxoSmithKline PLC Beconase nasal spray was superior to placebo treatment, Rigel said. ... - San Jose Mercury News,

Rigel's Failure Could Cause Jitters For Pfizer  Dec 1, 2005
..."In light of the fact that allergen exposure and the performance of the active control (Beconase, an intranasal steroid) was as expected, we speculate that the ... - Forbes

Drugs stocks climb while Rigel dives on drug data  Dec 1, 2005
The same trial showed that another drug, Beconase AQ, was effective. ... Rigel's bad news appeared to give a boost to GlaxoSmithKline, which markets Beconase AQ. ... - Investor's Business Daily (subscription)

Poor drug trial trips Rigel Pharma  Dec 1, 2005
...allergy symptoms. , , ) , over a 7-day period. Beconase AQ was found to be superior to the placebo treatment in the trial. "We are ... - MarketWatch

Health Stocks in Motion  Dec 1, 2005
...the earlier phase II 'Park' study of R112 demonstrated a statistically significant reduction in the symptoms associated with the allergies." Beconase AQ, a ... - TheStreet.com

Nasal Sprays  Sep 24, 2005
Vancenase and Beconase (beclomethasone), Nasarel (flunisolide), Rhinocort (budesonide), Nasonex (mometasone), and Flonase (fluticasone), to name a few, can get ... - allergies.about.com

Comparative Phase II Clinical Trial of R112 for Allergy Treatment  Aug 10, 2005
This trial, which is expected to enroll approximately 375 patients, will be a randomized, double-blind study comparing R112 to placebo and Beconase AQ(R ... - Medical News Today (press release),

Over the counter: nasal steroids for blocked noses  Aug 19, 2005
Cost of treating Beconase Hay Fever, £8.99 for 180 sprays (generic £3.38) and Flixonase Allergy, £6.79 for 60 sprays (no generic). ... - Times Online, <**results**>

Two lines of attack to contain allergy symptoms  Jun 26, 2005
These should be used as sprays or inhalers rather than taken by mouth or given by injection. The nasal sprays include such brands as Flixonase or Beconase. ... - Times Online

Pharma Focus Now on Building Their Respiratory Portfolios  Jun 29, 2005
Major players like GlaxoSmithKline have pipeline products like Beconase (allergies), Becotide/Beclovent (asthma and chronic obstructive pulmonary disease ... - PharmaLive.com (press release)

Dr Thomas Stuttaford: hay fever  Jun 24, 2005
A steroid nasal spray such as Flixonase, Beconase, Nasonex or Rhinocort, taken with either a second-generation antihistamine or as a complete treatment, is ... - Times Online

Wit Animation Creates CG Spot for McDonald's  Jun 11, 2005
...content. Wit Animation landed its first TV commercial in 2001 for Beconase Hay Fever Spray via ad agency McCann-Erickson in the UK. ... - Media Workstation,

Two lines of attack to contain allergy symptoms  Jun 26, 2005
These should be used as sprays or inhalers rather than taken by mouth or given by injection. The nasal sprays include such brands as Flixonase or Beconase. ... - Times Online,

Dr Thomas Stuttaford: hay fever  Jun 24, 2005
A steroid nasal spray such as Flixonase, Beconase, Nasonex or Rhinocort, taken with either a second-generation antihistamine or as a complete treatment, is ... - Times Online,

Wit Animation Creates CG Spot for McDonald's  Jun 17, 2005
...content. Wit Animation landed its first TV commercial in 2001 for Beconase Hay Fever Spray via ad agency McCann-Erickson in the UK. ... - DTV Professional,

Medicines Help Nip Allergy Season in the Bud  Apr 12, 2005
Examples include Beconase, Rhinocort, Nasarel, Flonase, Nasonex and Nasacort, which are all prescription-only. Mast cell stabilizers. ... - Press-Enterprise (subscription),

Allergy agony begins early  Feb 24, 2005
...alcohol. But, the only drug I'm interested in is Beconase, the stuff I squirt up my nose to get my symptoms under control. Early ... - Seattle Times


Other information


Indication
For the maintenance treatment of asthma as prophylactic therapy in patients 5 years of age and older

Pharmacology
Beclomethasone, a synthetic halogenated glucocorticoid with antiinflammatory and vasoconstrictive effects, is used for treating steroid-dependent asthma, allergic or nonallergic rhinitis, or recurrent nasal polyps.

Mechanism Of Action
Unbound corticosteroids cross cell membranes and bind with high affinity to specific cytoplasmic receptors. The result includes inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

Drug Category
Antiarrhythmic Agents; Glucocorticoids; Anti-inflammatory Agents; Corticosteroids; ATC:A07EA07; ATC:D07AC15; ATC:R01AD01; ATC:R03BA01

Brand Names/Synonyms
Aerobec; Aldecin; Anceron; Andion; Beclacin; Becloforte; Beclomet; Beclometasona [Inn-Spanish]; Beclometasondipropionat Mikron; Beclometasondipropionat Mikron.; Beclometasone; Beclometasonum [Inn-Latin]; Beclomethasone; Beclorhinol; Becloval; Beclovent; Becodisks; Beconase; Beconase Aq; Beconasol; Becotide; Clenil-A; Entyderma; Inalone; Korbutone; Propaderm; Qvar; Qvar 80; Rino-Clenil; Sanasthmax; Sanasthmyl; Vancenase; Vancenase Aq; Vanceril; Vanceril Double Strength; Viarex; Viarox

Dosage Forms
Oral inhalation; Nasal inhalation; Nasal Spray

Absorption
mean peak plasma concentration was 88pg/ml at 0.5 hour

Interactions
Interactions for Beclomethasone:
Albuterol, Antihistamines, antidiabetic drugs, diuretics, digitalis.

Chemical IUPAC Name
[9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-propanoyloxyacetyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate

Chemical Formula
C28H37ClO7

Half Life
2.8 hours

Drug Type
Approved Drug

# Accession No
APRD00564

CAS Registry Number
4419-39-0

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