Bactroban: profile and news

GlaxoSmithKline's Topical Antibacterial Retapamulin Accepted for ... Feb 14, 2006
...established heritage in the development of novel anti-infectives to meet clinical needs, including the topical antibacterial agent Bactroban® (mupirocin) as ... - Yahoo! News (press release)

Fougera Introduces the First Unit-of-Use Delivery System for ... Dec 1, 2005
This product is AB-rated to Bactroban(R) by GlaxoSmithKline and is now available in a 0.9 g unit-of-use foilpac(R), box of 72 as well as a 22 g tube (see ... - PR Newswire (press release),

Taro Gets FDA OK for Generic Bactroban Sep 23, 2005
...said Friday it received Food and Drug Administration approval for its generic version of GlaxoSmithKline PLC's Bactroban ointment, used to treat impetigo. ... - MSN Money

Taro gets FDA OK for generic impetigo ointment Sep 23, 2005
Profile, Research) on Friday said US regulators approved its generic version of GlaxoSmithKline Plc's (GSK.L: Quote, Profile, Research) Bactroban ointment to ... - Reuters

Taro Receives Approval For Mupirocin Ointment USP, 2% ANDA Sep 23, 2005
Taro's mupirocin ointment is bioequivalent to GlaxoSmithKline's Bactroban Ointment(R), 2%. Mupirocin ointment is a prescription antibiotic product used for the ... - PrimeZone (press release),

Nabi Biopharmaceuticals Appoints Vice President of Sales and ... 08 Sep 2005
...efforts for antibiotic products for infectious diseases and Staphylococcal infections, including Augmentin(R), Zinnat(R), Timentin(R), and Bactroban(R). Mr ... - PR Newswire (press release),

Intertrigo and Common Secondary Skin Infections Aug 30, 2005
...patients (adults and children) with GABHS may be a concomitant or independent regimen of topical therapies (eg, mupirocin [Bactroban], erythromycin); oral ... - American Family Physician

Free Health Stuff for Your Kids Aug 19, 2005
...have sample of topical antibiotics, such as Oculfox, Vigamox and Ciloxan for pink-eye, Floxin, Cipro-DEX and Cipro HC for swimmers ear, and Bactroban for skin ... - pediatrics.about.com

The joy of giving Jul 16, 2005
...maintenance medicine are: unasyn 750 mg (twice a day); ensure powder (Robert cannot eat solid foods): celocoxib 200 mg; oraallex gargle; and bactroban ointment ... - Manila Bulletin <**results**>

Picking nose likely resulted in infection ASK DR. H MITCHELL HECHT Jul 5, 2005
The good news is that Mupirocin (Bactroban) nasal ointment applied three times a day for a period of 5-7 days should that care of your infection. ... - Wilkes Barre Times-Leader

Free Health Stuff for Your Kids Jun 21, 2005
...have sample of topical antibiotics, such as Oculfox, Vigamox and Ciloxan for pink-eye, Floxin, Cipro-DEX and Cipro HC for swimmers ear, and Bactroban for skin ... - pediatrics.about.com

Other information

Indication
For the treatment of staphylococci nasal carriers

Pharmacology
Mupirocin, an antibiotic produced from Pseudomonas fluorescens, is structurally unrelated to any other topical or systemic antibiotics. Mupirocin is used to treat infection caused by Staphylococcus aureus and beta-hemolytic streptococci including Streptococcus pyogenes. This antibiotic has little, if any, potential for cross-resistance with other antibiotics.

Mechanism Of Action
Mupirocin reversibly binds to bacterial isoleucyl-tRNA synthetase, an enzyme which promotes the conversion of isoleucine and tRNA to isoleucyl-tRNA, resulting in the inhibition of bacterial protein and RNA synthesis.

Drug Category
Anti-bacterial Agents; Antibiotics; ATC:D06AX09; ATC:R01AX06

Brand Names/Synonyms
Bactoderm; Bactroban; Bactroban Nasal; Centany; MRC; Mupirocin; Mupirocine; PSEUDOMONIC ACID; Turixin

Dosage Forms
Topical ointment, nasal spray

Absorption
no measurable systemic absorption

Interactions
Interactions for Mupirocin:

No information provided.

Chemical IUPAC Name
13-[3,4-dihydroxy-5-[[3-(2-hydroxy-1-methyl-propyl)oxiran-2-yl]methyl]tetrahydropyran-2-yl]-12-methyl-10-oxo-tridec-11-enoicacid

Chemical Formula
C26H44O8

Half Life
20 to 40 minutes

Drug Type
Approved Drug

# Accession No
APRD00162

CAS Registry Number
12650-69-0