Bactrim: profile and news






Does God Heal Today?  Feb 4, 2006
Later I went on still other drugs, and took Bactrim to fight off infections. Although I didn't have any serious side effects, I just didn't feel right.. ... - Blogcritics.org,

OUTBREAK INVESTIGATION  Feb 1, 2006
...it would be presumptively Staphylococcus aureus. He was placed on a course of antibiotics, Bactrim® DS. The outer edge of the area ... - Infection Control Today,

AIDS drugs don't work for all  Feb 4, 2006
...one pill a day each to interfere with the virus' ability to make DNA); Zithromax (one pill a week to prevent opportunistic infections); and Bactrim (one pill a ... - Pittsburgh Post Gazette,

CROI News Feature: Experts divided over the future of treatment ...  Feb 9, 2006
...fourteen occurred with documented bacteraemia, despite everyone in this arm being prophylactically prescribed the antibiotic co-trimoxazole (Bactrim/Septrin). ... - Aidsmap,

Bactrim could help HIV-infected children in poor countries  Jan 25, 2006
A new systematic review highlights strong results from a single study at the center of mounting support for worldwide use of the low-cost drug Bactrim to help ... - News-Medical.net,

Does God Heal Today?  Feb 4, 2006
Later I went on still other drugs, and took Bactrim to fight off infections. Although I didn't have any serious side effects, I just didn't feel right.. ... - Blogcritics.org,

OUTBREAK INVESTIGATION  Feb 1, 2006
...it would be presumptively Staphylococcus aureus. He was placed on a course of antibiotics, Bactrim® DS. The outer edge of the area ... - Infection Control Today,

AIDS drugs don't work for all  Feb 4, 2006
...one pill a day each to interfere with the virus' ability to make DNA); Zithromax (one pill a week to prevent opportunistic infections); and Bactrim (one pill a ... - Pittsburgh Post Gazette,

A prescription for practicing bad medicine  Jan 29, 2006
With another antibiotic, bactrim, an unfortunate few will develop a severe reaction called Stevens-Johnson syndrome, where the skin and mucous membranes ... - San Francisco Chronicle,

Whooping cough case confirmed in Olean  Jan 31, 2006
...to spread pertussis may be reduced with antibiotic treatment, such as Zithromax, for five days or Erythromyein for two weeks, as well as Riaxin or Bactrim. ... - Olean Times Herald,

UC scientist awarded for fungus study  Jan 17, 2006
New medication is needed because the commonly used antibiotic, Bactrim, works well against pneumocystis when it comes to AIDS, but half the patients can't ... - News Record,

FLAVORx Enhances Treatment Options for Pediatric Oncology Patients  Jan 19, 2006
3. Acyclovir (to prevent viral infections)- Orange Cream, Banana, Cherry. 4. Septra/Bactrim (to prevent some types of pneumonia)- Grape, Bubblegum, Watermelon. ... - PR Web (press release),

Tips on how to treat sinusitis  Dec 7, 2005
...production. For the first shot at treatment, the guidelines call for simple antibiotics like amoxicillin or bactrim for 10 to 14 days. ... - WTNH,

Dear Doctor: How does MRSA spread?  Nov 22, 2005
In the one to two days before lab results are available, drugs effective against MRSA such as sulfamethoxazole/trimethoprim (Bactrim) and clindamycin may be ... - Pittsburgh Post Gazette,

Help! What do I do about 'honeymoon cystitis'?  Nov 14, 2005
...regular basis. The most common antibiotics are Macrodantin, Bactrim, Levoquin, Cipro (in low doses), though there are others as well. - Standard-Speaker,

Interpharm Announces Revenue and Earnings for the Fiscal Quarter ...  Nov 22, 2005
...revenue. Also, the Company launched Sulfamethoxazole and Trimethoprim ("SMT"), commonly known as Bactrim, in September, 2005. The ... - Black Enterprise,

Avian flu threat real, but staph infection here now  Nov 15, 2005
...to penicillin and its derivatives and is most often treated with alternative drugs such as Trimethoprim-Sulfamethoxazole (Bactrim), ciprofloxacin (Cipro) and ... - Buffalo News,

Lannett Selling Generic Bactrim  Sep 14, 2005
...and is used to treat infections. Lannett said the medication is generic equivalent of Bactrim. According to NDC Health, sales for ... - TheStreet.com

Lannett begins selling generic Bactrim  Sep 14, 2005
...said Wednesday it began selling its generic version of United Research Laboratories Inc.'s Bactrim, which is used to treat various types of infection. ... - BusinessWeek

Interpharm Launches Generic Equivalent of Bactrim(R) Antibiotic  Sep 21, 2005
IPA) today announced the launch of Sulfamethoxazole and Trimethoprim ("SMT") single and double strength tablets, which are sold under the name Bactrim(R). SMT ... - Business Wire (press release),

Web Extra: Consumer Reports: Reducing risks for getting a super ...  Oct 9, 2005
...however, these infections can usually be treated with common oral medications such as clindamycin (Cleocin) and trimethoprim-sulfamethoxazole (Bactrim, Septra ... - Asbury Park Press,

Lannett Company Launches New Generic Product  Sep 14, 2005
...tract infections, bronchitis, ear infections (otitis), traveler's diarrhea, and Pneumocystis carinii pneumonia and is the generic equivalent of Bactrim(R) and ... - Business Wire (press release),

URL/Mutual Tracking to Achieve Another Record Year in Sales ...  Sep 12, 2005
URL/Mutual currently holds 3 approved NDA applications for the Bactrim product family, which it acquired in late 2004. URL/Mutual's ... - PR Newswire (press release),

Staph Infections Are Becoming More Common  Sep 15, 2005
..."The two antibiotics we will typically use now are bactrim, which is not a super duper antibiotic, but the community-acquired MRSA is sensitive to bactrim. ... - Pittsburgh Channel.com,

Many meds don't mix with the sun  Sep 21, 2005
...oxytetracycline (Terra-mycin), pyrazinamide, ritonavir (Norvir), saquinavir (Fortovase, Invirase), sulfamethoxazole/tri-methoprim (Bactrim), sulfasala-zine ... - Pioneer Press,

HIV skeptic faces child's death  Sep 25, 2005
...positive. That would have meant giving her a stronger antibiotic, such as Bactrim, instead of the relatively low-powered amoxicillin. ... - Seattle Times,

Help! What do I do about 'honeymoon cystitis'?  Sep 6, 2005
...regular basis. The most common antibiotics are Macrodantin, Bactrim, Levoquin, Cipro (in low doses), though there are others as well. - MSNBC

Sharing hair items can be a lousy idea  Aug 30, 2005
...said. A type of antibiotic called Bactrim also can be used, but some resistance has been reported with that treatment, he said. ... - Baxter Bulletin,

Heads up! Return to school may mean discovery of lice  Aug 28, 2005
...internally. Trimethoprim-sulfamethoxazole (Septra, Bactrim) is an oral antibiotic, which has been shown to be effective against head lice. ... - KPCnews.com,

Quad City not RGV’s only enemy this week  Aug 3, 2005
...big calf. Rasmussen was immediately treated with the antibiotics Keflex and Bactraban and the antibiotic ointment Bactrim. The Dorados ... - Monitor

Shigellosis Outbreak Expands Beyond Day Care  Jul 29, 2005
Rowe said that the health department is alerting doctors that this strain of shigella is resistant to ampicillin and Bactrim, two common antibiotics, so ... - RedNova.com

pedi-CURE chyron script  Jul 24, 2005
...resistant to certain antibiotics.". Julie Kim Hirota on videotape: "Augmentin, Bactrim, Dicoxyclin, Refampin and Bioxin.". Dr. Anne Lucky ... - WCPO

Cancer Chronicles | Pulling for life  Jul 25, 2005
...infection. But months of treatment with both oral and intravenous antibiotics - Keflex, vancomycin and Bactrim - didn't help. So ... - Philadelphia Inquirer <**results**>

Native Americans lose out on AIDS funds  Jul 4, 2005
...old Mississippi Choctaw from Oklahoma City, keeps his pills in a tin box decorated with pictures of angels: Kaletra, Viread, Emtriva and Bactrim, three anti ... - Arizona Republic

Drug-induced hypoglycemia  Jun 12, 2005
Rarer causes of low blood glucose include the use of quinidine, quinine, beta-blocker drugs, MAO inhibitors (a type of antidepressant), Bactrim (an antibiotic ... - drkoop.com

Sun, heat and medications  Jun 22, 2005
These include the diurectics hydrochlorothiazide and furosemide; the antibiotics ciprofloxacin, bactrim and tetracycline; nonsteroidal anti-inflammatory drugs ... - Rochester Democrat and Chronicle,


Other information


Indication
For the treatment of bronchitis, prostatitis and urinary tract infections

Pharmacology
Sulfamethoxazole is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA). Sulfamethoxazole is normally given in combination with Trimethoprim (a dihydrofolate reductase inhibitor). Studies have shown that bacterial resistance develops more slowly with the combination of the two drugs than with either Trimethoprim or Sulfamethoxazole alone.

Mechanism Of Action
Sulfonamides inhibit bacterial dihydrofolate synthetase, causing interference in the conversion of p-aminobenzoic acid (PABA) into folic acid. As folic acid is a coenzyme responsible for the transport of one-carbon fragments from one molecule to another, it is an essential component of bacterial development. Pyrimethamine and trimethoprim inhibit dihydrofolate reductase, the immediate next step, and therefore act synergistically with the sulfonamides.

Drug Category
Anti-Infectives; Sulfonamides; ATC:J01EC01

Brand Names/Synonyms
A047; Apo-Sulfamethoxazole; Azo Gantanol; Azo-Gantanol; Bactrim; Bactrim Ds; Bactrim Pediatric; Bactrimel; Co-Trimoxazole; Cotrim; Cotrim D.S.; Eusaprim; Fectrim; Gamazole; Gantanol; Gantanol-Ds; MS 53; Metoxal; Radonil; SIM; Septra; Septra Ds; Septra Grape; Septran; Septrin; Simsinomin; Sinomin; Sulfamethalazole; Sulfamethoprim; Sulfamethoprim-Ds; Sulfamethoxazol; Sulfamethoxazole; Sulfamethoxazole & Trimethoprim; Sulfamethoxazole Trimethoprim; Sulfamethoxizole; Sulfamethylisoxazole; Sulfatrim; Sulfatrim Pediatric; Sulfatrim-Ds; Sulfatrim-Ss; Sulfisomezole; Sulmeprim; Sulmeprim Pediatric; Sulpha-Methoxizole; Sulphamethalazole; Sulphamethoxazol; Sulphamethoxazole; Sulphamethoxazole Bp 98; Sulphamethylisoxazole; Sulphisomezole; Trib; Trimeth/Sulfa; Trimetoprim-Sulfa; Urobak; Uroplus Ds; Uroplus Ss

Dosage Forms
TABLET

Absorption
Sulfamethoxazole is rapidly absorbed following oral administration.

Interactions
Interactions for Sulfamethoxazole:

In elderly patients concurrently receiving certain diuretics, primarily thiazides, an increased incidence of thrombopenia with purpura has been reported.

It has been reported that sulfamethoxazole may prolong the prothrombin time in patients who are receiving the anticoagulant warfarin. This interaction should be kept in mind when Gantanol is given to patients already on anticoagulant therapy, and the coagulation time should be reassessed.

Sulfamethoxazole may inhibit the hepatic metabolism of phenytoin. At a 1.6-g dose, sulfamethoxazole produced a slight but significant increase in the half-life of phenytoin but did not produce a corresponding decrease in the metabolic clearance rate. When administering these drugs concurrently, one should be alert for possible excessive phenytoin effect.

Sulfonamides can also displace methotrexate from plasma protein-binding sites, thus increasing free methotrexate concentrations.

The presence of sulfamethoxazole may interfere with the Jaffé alkaline picrate reaction assay for creatinine, resulting in overestimations of about 10% in the range of normal values.



Chemical IUPAC Name
4-amino-N-(5-methyloxazol-3-yl)-benzenesulfonamide

Chemical Formula
C10H11N3O3S

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00076

CAS Registry Number
723-46-6

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