Altace: profile and news






'Viagra' heart problem treatment  07 Mar 2006
People with pulmonary arterial hypertension (PAH) could be offered a new treatment, Revatio, with the same active ingredient, sildenafil citrate, as Viagra. ... - Scotsman,

Myogen Reports 2005 Results  07 Mar 2006
The Company recently completed a Phase 1 study examining the potential for drug-drug interactions between ambrisentan and sildenafil. ... - Business Wire (press release),

Sildenafil in the Treatment of Antipsychotic-Induced Erectile ...  Mar 2, 2006
This report studied the efficacy and tolerability of sildenafil citrate in patients with antipsychotic-induced erectile dysfunction. ... - Am J Psychiatry (subscription)

What could be causing my night sweats?  Mar 5, 2006
Other implicated medications include tamoxifen (often used in breast cancer), hydralazine for blood pressure treatment and Sildenafil (Viagra). ... - The Herald,

Viagra for overcoming sexual failure  Mar 3, 2006
And all the credit behind Viagra’s growing success rate is attributed to the presence of its active ingredient Sildenafil citrate. ... - LiveArticles.org,

Director-General's Statement Under Section 98  Feb 28, 2006
A second herbal product Nasutra, has been found to contain the prescription medicine Sildenafil, which is prescribed for the treatment of erectile dysfunction. ... - Scoop.co.nz (press release),

Warnings issued for two herbal products  Feb 28, 2006
Nasutra – labelled as "the natural choice for maximum sexual performance" – has been found to contain the prescription medicine Sildenafil, which is ... - Stuff.co.nz,

Ministry warns of dangers of products  Feb 28, 2006
The product Nasutra contains the prescription medicine Sildenafil which is known to interfere with some heart medication and may be fatal to some users. ... - Newstalk ZB,

* MACLEANS PROTECT TOOTHPASTES * ILLEGAL HERBAL MEDICINES ...  Mar 2, 2006
One contains sildenafil, the other contains sibutramine. ... Sildenafil is known to interfere with some heart medication and could be fatal to some individuals. ... - newswire.co.nz,

The Viagra Hardsell  Feb 27, 2006
...“Till date, pharma companies have not made it clear that Sildenafil Citrate and Tadafil tablets are only for those who suffer from ED and are not for ... - Business Standard,

Illegal Herbal Medicines  Mar 1, 2006
A second herbal product, Nasutra, has been found to contain the prescription medicine sildenafil, which is prescribed for the treatment of erectile dysfunction ... - Consumer Online,

Rock Solid Radiofrequency Identification  Mar 3, 2006
In January, Pfizer became the first pharmaceutical company to track a product’s production RFID technology with its popular product Viagra (sildenafil citrate ... - Pharmaceutical Processing,

Medicines that made a difference  Mar 3, 2006
They found that sildenafil citrate had the side effect of causing erections. In 1991, development began in earnest, and Viagra hit the pharmacies in 1998. ... - Saga Health News,

Viagra Hates Erectile Dysfunction  Feb 23, 2006
...male persons with Erectile Dysfunction. The miracle drug is Sildenafil Citrate commonly known as Viagra. The Viagra pills will help ... - LiveArticles.org,

Generic Drugs- Combo of Effectuality and Safety  Feb 22, 2006
2. Generic drugs are of the same composition as that of Viagra or Cialis and contain the same chemical compounds called Sildenafil and Tadalafil. ... - LiveArticles.org,

(PZ) Actelion Announces Full Year 2005 Financial Results  Feb 22, 2006
...costs associated with the COMPASS program, a comprehensive clinical effort to evaluate the long-term outcome of either the bosentan/sildenafil combination or ... - Houston Chronicle,

Famed cardiologist shares insights  Feb 24, 2006
Viagra, or sildenafil, was originally developed to treat angina, a kind of heart pain associated with constricted coronary arteries, but it is more famous as a ... - Johns Hopkins News-Letter,

VCU study shows Levitra may protect the heart  Feb 15, 2006
PDE-5 inhibitor drugs, such as vardenafil, sildenafil, the generic term for Viagra, and tadalafil, the generic name for Cialis, are able to preserve cGMP, and ... - Innovations-Report,

VIVUS Reports 2005 Fourth Quarter and Full-Year Financial Results  Feb 23, 2006
...hemodynamic effects (blood pressure and heart rate) of glyceryl trinitrate (GTN) in subjects pretreated with placebo, avanafil, and sildenafil citrate showed ... - MSN Money

Study: Viagra increases self-esteem  Feb 28, 2006
...administered the Self-Esteem and Relationship Questionnaire to a group of 93 men with erectile dysfunction before and after treatment with sildenafil, the drug ... - United Press International

Pfizer's Viagra could help Crohn's disease  Feb 27, 2006
...infected sites. The team used impotence drug Viagra (sildenafil) to artificially correct the blood flood response to normal levels. The ... - Pharmaceutical Business Review

Chinese medicines found containing western ingredients  Mar 2, 2006
One sample contained Tadalafil, the main ingredient of Cialis, and Sildenafil Citrate, the main ingredient of Viagra, while the other contained Tadalafil and ... - eTaiwan News,

Drug Control Authority needs to perk up  Feb 27, 2006
Ministry's warning on the dangers of consuming "Orgacare Unik Plus-1" which was found to contain the restricted drug ingredients "sildenafil" and "tadalafil". ... - Malaysia Kini,

Use Of Statins Shows Improvement In Erectile Performance Of Some ...  Feb 23, 2006
The article is titled, "Can Atorvastatin Improve the Response to Sildenafil in Men with Erectile Dysfunction Not Initially Responsive to Sildenafil? ... - Science Daily (press release)

New Insight Into Cause Of Crohn's Disease  Feb 27, 2006
The researchers, who report their findings in an Article in this week's issue of The Lancet, also suggest that sildenafil (Viagra) might help in the treatment ... - Medical News Today (press release),

Viagra plays saviour of the deprived sex  Feb 13, 2006
Viagra is said to be the most effective with 80 percent success rate. This effectiveness is due to the presence of its active ingredient Sildenafil citrate. ... - LiveArticles.org,

Viagra an answer for Impotence  Feb 4, 2006
...of love making due to erectile dysfunction. Viagra has Sildenafil Citrate as an active ingredient. The effect of Viagra could be ... - LiveArticles.org,

GENERIC VIAGRA: VITAL KEY IN RELATIONSHIPS  Feb 16, 2006
...to a large extent. Generic Viagra also primarily contains sildenafil citrate and works in the same way as Viagra. It controls the ... - LiveArticles.org,

When Viagra Doesn't Work, Lipitor May Assist  Feb 21, 2006
PHILADELPHIA, June 21 - If Viagra (sildenafil) doesn't go the job, maybe all it needs is a kick start with Lipitor (atorvastatin), a small study here suggested ... - MedPage Today,

China & Hong Kong: Recent Developments In Intellectual Property  Feb 23, 2006
The Viagra patent, which is owned by Pfizer in China and which covers the use of sildenafil in the treatment of erectile dysfunction, was invalidated in a much ... - Mondaq News Alerts,

Ignite Your Cold Romance With Viagra  Feb 20, 2006
Viagra contains the chemical sildenafil citrate, which helps the male sex organ to get engorged with blood, by increasing the blood flow into the male sex ... - LiveArticles.org,

Oral Pentoxifylline May Have Efficacy In The Treatment Of ...  Feb 23, 2006
The patient also had an hourglass deformity of his penis on exam. Erections were less firm than previously but did respond to sildenafil. ... - Medical News Today (press release),

Weak immune response may cause Crohn's disease  Feb 24, 2006
...study, told New Scientist. The researchers then tested Viagra (sildenafil) to see its effect on blood flow. “This resulted in ... - New Scientist (subscription),

Multimedia News Release - Heart Failure Society Supports the Use ...  Feb 23, 2006
...effect. Caution should be exercised if BiDil is used with MAO inhibitors, alcohol, sildenafil, vardenafil or tadalafil. Headache ... - PR Newswire (press release),

SEX: FUNDAMENTAL AND LONG-LASTING HUMAN DRIVE  Feb 16, 2006
Actually, sildenafil citrate (generic name for Viagra) had been in use for the treatment of angina for the past 20 years – but without much success. ... - LiveArticles.org,

Current outcomes and risk factors for the Norwood procedure  Feb 9, 2006
...size. However, recent advances in postoperative management, such as inhaled nitric oxide and sildenafil, might also have an effect. ... - The Journal of Thoracic and Cardiovascular Surgery

Analysis: Do ED Drugs Have Heart Benefit?  Feb 15, 2006
Furthermore, it is proof that the positive findings of prior studies on (Viagra) sildenafil extend to another PDE-5 inhibitor, he added. - International News Service,

Bullous disease of the lung and cannabis smoking: insufficient ...  Feb 9, 2006
Some people who take Viagra (sildenafil) die (indeed all people who take Viagra will eventually die) but it took the medical statistician Stephen Senn to ... - Journal of the Royal Society of Medicine

'Big Science': Top Funding For EU Lung Research Project ...  Feb 17, 2006
Richard Trembath (King's College, London, United Kingdom) or the introduction of sildenafil (Viagra®) into the treatment of PH by a team of physicians led by ... - Medical News Today (press release),

Boehringer Ingelheim Announces 48-week Results from Aptivus(R) ...  Feb 9, 2006
Caution should be used when taking APTIVUS/r with drugs to treat impotence, including sildenafil, tadalafil or vardenafil because blood levels of these drugs ... - PR Newswire (press release),

Myogen Reports Positive Top Line Results for Ambrisentan LFT ...  Feb 13, 2006
...aminotransferase abnormalities. Also, 17 (47%) of the patients were receiving concomitant sildenafil therapy. Patients received ... - Yahoo! News (press release)

Although the Erectile Dysfunction Drugs Market in Japan was worth ...  Feb 6, 2006
The ED market in Japan is currently dominated by the two phosphodiesterase (PDE)-5 inhibitors sildenafil (Pfizer's Viagra) and vardenafil (Bayer's Levitra). ... - Business Wire (press release),

Pfizer plans Viagra lessons for doctors to push up sales  Feb 1, 2006
...“For that, one would rather prescribe tadalafil. It acts better and is the latest development over sildenafil citrate.�. Some ... - Daily News & Analysis,

Head-to-Head Trials Published in the Third Quarter of 2005 ...  Feb 2, 2006
The approval of Pfizer's Revatio (sildenafil) and Servier's Procoralan (ivabradine) is likely to have the largest impact on the cardiovascular market. ... - International News Service,

Generic Drugs Or Brand-Name Drugs – An Eternal Dilemma  Feb 1, 2006
...name counterparts. A very good example of generic drug is sildenafil citrate which is better known by its brand-name Viagra. The ... - LiveArticles.org,

Gene Logic: Rescue Squad  Feb 1, 2006
Viagra (sildenafil), Botox (botulinum), and even thalidomide, for instance, have become successful drugs when they proved effective for indications their ... - PharmExec.com,


Other information


Indication
Indicated for diuretics and digitalis in congestive heart failure as adjunctive therapy; prophylaxis in post MI.

Pharmacology
Ramipril is an angiotensin-converting enzyme (ACE) inhibitor similar to benazepril, fosinopril, and quinapril. An inactive prodrug, ramipril is converted to ramiprilat in the liver and is used to treat hypertension and heart failure, to reduce proteinuria and renal disease in patients with nephropathies, and to prevent stroke, myocardial infarction, and cardiac death in high-risk patients.

Mechanism Of Action
Ramiprilat, the active metabolite, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and an increase in plasma renin. Ramiprilat may also act on kininase II, an enzyme identical to ACE that degrades the vasodilator bradykinin.

Drug Category
Antihypertensive Agents; Angiotensin-converting Enzyme Inhibitors; ATC:C09AA05

Brand Names/Synonyms
Acovil; Altace; Carasel; Cardace; Delix; HOE 498; Hytren; Lostapres; Pramace; Quark; Ramace; Ramipril; Ramipril [Usan:Ban:Inn]; Ramiprilum [Latin]; Triatec; Tritace; Unipril; Vesdil

Dosage Forms
CAPSULE

Absorption
The extent of absorption is at least 50-60% and is not significantly influenced by the presence of food in the GI tract, although the rate of absorption is reduced.

Interactions
Interactions for Ramipril:

With nonsteroidal anti-inflammatory agents: Rarely, concomitant treatment with ACE inhibitors and nonsteroidal anti-inflammatory agents have been associated with worsening of renal failure and an increase in serum potassium.

With Diuretics: Patients on diuretics, especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with ramipril. The possibility of hypotensive effects with ramipril can be minimized by either discontinuing the diuretic or increasing the salt intake prior to initiation of treatment with ramipril. If this is not possible, the starting dose should be reduced.

With Potassium Supplements and Potassium-sparing Diuretics: Ramipril can attenuate potassium loss caused by thiazide diuretics. Potassium-sparing diuretics (spironolactone, amiloride, triamterene, and others) or potassium supplements can increase the risk of hyperkalemia. Therefore, if concomitant use of such agents is indicated, they should be given with caution, and the patient's serum potassium should be monitored frequently.

With Lithium: Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving ACE inhibitors during therapy with lithium. These drugs should be coadministered with caution, and frequent monitoring of serum lithium levels is recommended. If a diuretic is also used, the risk of lithium toxicity may be increased.

Other: Neither ramipril nor its metabolites have been found to interact with food, digoxin, antacid, furosemide, cimetidine, indomethacin, and simvastatin. The combination of ramipril and propranolol showed no adverse effects on dynamic parameters (blood pressure and heart rate). The co-administration of ramipril and warfarin did not adversely affect the anticoagulant effects of the latter drug. Additionally, co-administration of ramipril with phenprocoumon did not affect minimum phenprocoumon levels or interfere with the subjects' state of anti-coagulation.



Chemical IUPAC Name
4-[2-(1-ethoxycarbonyl-3-phenyl-propyl)aminopropanoyl]-4-azabicyclo[3.3.0]octane-3-carboxylicacid

Chemical Formula
C23H32N2O5

Half Life
2-4 hours

Drug Type
Approved Drug

# Accession No
APRD00009

CAS Registry Number
87333-19-5

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