|
![]() |
|
|
Alphagan: profile and news
Fitch Places Allergan's Ratings on Rating Watch Negative Nov 15, 2005 Allergan Receives Positive Opinions for COMBIGAN(TM) from 21 ... Sep 28, 2005 FDA Approvals: Aceon, 0.1% Alphagan P, Namenda Oral Solution Aug 25, 2005 New Formulation of Allergan's ALPHAGAN(R) P Receives US FDA ... Aug 19, 2005 Allergan Bolsters Generic Defense Strategy Aug 22, 2005 Eye On Stocks For Monday, Aug. 22 Aug 19, 2005 Stocks to Watch Northwest, Merck, HJ Heinz Aug 20, 2005 Movers & Shakers Aug 22, 2005 Today's Orange County business briefs Aug 20, 2005 Northwest, Merck, HJ Heinz, Motorola, more Aug 20, 2005 Allergan Reports Second Quarter Operating Results and Increases ... Jul 27, 2005 Fitch Affirms Allergan's 'A+' Rating; Outlook Stable Jul 18, 2005 Allergan Reports Second Quarter Operating Results and Increases ... Jul 27, 2005 Fitch Affirms Allergan's 'A+' Rating; Outlook Stable Jul 18, 2005 JPMorgan Upgrades Allergan Jun 2, 2005 Allergan Reports First Quarter Operating Results and Increases ... Apr 27, 2005 Anne Loomis Joins Torre Lazur McCann West 08 Apr 2005 Other information Indication For the lowering of intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Pharmacology Brimonidine significantly lowers intraocular pressure with minimal effects on cardiovascular and pulmonary parameters. It lowers intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow. Mechanism Of Action Brimonidine is an alpha adrenergic receptor agonist. It has a peak ocular hypotensive effect occurring at two hours post-dosing. Fluorophotometric studies in animals and humans suggest that Brimonidine has a dual mechanism of action by reducing aqueous humor production and increasing uveoscleral outflow. Drug Category Antihypertensive Agents; EENT Drugs; ATC:S01EA05 Brand Names/Synonyms Alphagan; Alphagan P; Brimonidine; Brimonidine Tartrate; Bromoxidine; CHEMBANK1623 Dosage Forms 0.2% solution Absorption Minimal systemic absorption occurs after ocular insertion. Interactions -->Interactions for Brimonidine: Although specific drug interaction studies have not been conducted with ALPHAGAN® P, the possibility of an additive or potentiating effect with CNS depressants (alcohol, barbiturates, opiates, sedatives, or anesthetics) should be considered. Alpha-agonists, as a class, may reduce pulse and blood pressure. Caution in using concomitant drugs such as beta-blockers (ophthalmic and systemic), anti-hypertensives and/or cardiac glycosides is advised. Tricyclic antidepressants have been reported to blunt the hypotensive effect of systemic clonidine.It is not known whether the concurrent use of these agents with ALPHAGAN® P in humans can lead to resulting interference with the IOP lowering effect. No data on the level of circulating catecholamines after ALPHAGAN® P administration are available. Caution, however, is advised in patients taking tricyclic antidepressants which can affect the metabolism and uptake of circulating amines. Chemical IUPAC Name 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine Chemical Formula C11H10BrN5 Half Life 2 hours Drug Type Approved Drug # Accession No APRD00034 CAS Registry Number 59803-98-4 |
|
Home | About | Cancers | Treatment | Medications Copyright onconews.org 2005. All Rights Reserved. |