Aloxi: profile and news
Community-Acquired MRSA a Leading Cause of Skin and Soft-Tissue ... 07 Mar 2006
...acquired MRSA isolates (87%) were resistant only to beta-lactams and erythromycin; between 1% and 10% were also resistant to levofloxacin, clindamycin, rifampin ... - Medscape (subscription)
Antibiotic Tequin risky to diabetes patients Mar 5, 2006
Along with gatifloxacin, cephalosporin, levofloxacin, moxifloxacin, or ciprofloxacin were also studied, but no risk was found to be with these antibiotics. ... - Food Consumer,
Tequin Linked to High Risk of Dangerous Glucose Changes Mar 1, 2006
With the exception of slight increase in risk of hypoglycemia with levofloxacin, these risks were not shared by other fluoroquinolones, wrote Laura Y. Park ... - MedPage Today,
Outpatient Gatifloxacin Therapy and Dysglycemia in Older Adults Mar 1, 2006
...after outpatient treatment with a macrolide, a second-generation cephalosporin, or a respiratory fluoroquinolone (gatifloxacin, levofloxacin, moxifloxacin, or ... - New England Journal of Medicine (subscription),
National Report Card reveals antibiotic resistance and antibiotic ... Mar 2, 2006
The Report also examined another class of antibiotics called quinolones, and in particular levofloxacin, primarily used to treat respiratory and urinary tract ... - Canada NewsWire (press release),
Bristol-Myers drug raises diabetes risk -study Mar 1, 2006
In their survey of 1.4 million records, the researchers also found that a related drug, levofloxacin, also increased the risk of low blood sugar, but only by ... - Reuters
Antibiotic linked to blood-sugar changes: Study Mar 1, 2006
While one other drug in the class, called levofloxacin, appeared to slightly increase the risk of low blood sugar, Juurlink said the adverse effects on blood ... - Toronto Star,
Bristol-Myers's Tequin Linked to Blood-Sugar Swings (Update1) Mar 1, 2006
The only other drug implicated in blood-sugar abnormalities during the study was levofloxacin, a generic medication originally sold by Johnson & Johnson as ... - Bloomberg
Antibiotic gatifloxacin (Tequin) poses health risks Mar 1, 2006
...transmitted diseases. Other antibiotics in the same class include ciprofloxacin (Cipro, others) and levofloxacin (Levaquin, others). In ... - MayoClinic.com
Elusys' Anthrax Drug, Anthim, Superior to Antibiotic as a Post ... Feb 16, 2006
This study was designed to determine if the co-administration of Anthim and the antibiotic levofloxacin after exposure to a lethal, aerosolized anthrax-spore ... - PharmaLive.com (press release),
Elusys' Anthrax Drug, Anthim(TM), Superior to Antibiotic as a Post ... Feb 16, 2006
...and in combination with an antibiotic." This study was designed to determine if the co-administration of Anthim and the antibiotic levofloxacin after exposure ... - PR Newswire (press release),
Clostridium difficile: Old Scourge Becomes Far Worse Feb 9, 2006
...of previously identified molecular markers for increased virulence, and susceptibility to clindamycin and fluoroquinolones (levofloxacin, gatifloxacin, and ... - AAP Grand Rounds (subscription)
New Yorker infected with inhaled anthrax Feb 23, 2006
Health-care providers will use antibiotics (such as ciprofloxacin, levofloxacin, doxycycline, or penicillin) combined with the anthrax vaccine to prevent ... - Food Consumer,
Elusys: Anthrax drug bests antibiotic Feb 16, 2006
...of the drug in rabbits showed that 100 percent of the anthrax-exposed animals treated with Anthim in combination with the antibiotic levofloxacin survived, and ... - United Press International
Tamiflu prescribed concurrently with Warfarin: suspected increase ... Jan 28, 2006
In 2 cases, Clarithromycin and Levofloxacin respectively were reported as co-suspect medications; these drugs are known to interact with Warfarin and may cause ... - Xagena.it,
Head-To-Head Study Shows More Elderly Patients With Community ... Jan 24, 2006
...community-acquired pneumonia (CAP) recovered at days 3 to 5 of a 7 to 14 day course of treatment than those treated with LEVAQUIN (levofloxacin), according to ... - PR Newswire (press release),
SA study cites drug's role Jan 25, 2006
Doctors compared the effectiveness of moxifloxacin, a newer antibiotic sold under the brand name Avelox, with levofloxacin, or Levaquin, which has been the ... - San Antonio Express (subscription),
Newer Antibiotic More Effective At Treating Elders' Pneumonia Jan 26, 2006
...patients recovered within three to five days of therapy onset, compared to 90 percent of patients treated with the standard medication, levofloxacin. ... - Medical News Today (press release),
Newer Antibiotic more Effective at Treating Pneumonia in Senior ... Jan 24, 2006
...patients recovered within three to five days of therapy onset, compared to 90 percent of patients treated with the standard medication, levofloxacin, which is ... - SeniorJournal.com,
Newer antibiotic battles pneumonia better Jan 24, 2006
Antibiotic moxifloxacin HCI is 8 percentage points more effective in curing elderly pneumonia than the other standard drug, levofloxacin, researchers say. ... - United Press International
Bayer Drug Better Than Leading Pneumonia Treatment Jan 28, 2006
...acquired pneumonia (CAP) recovered at days three to five of a seven to 14 day course of treatment than those treated with Levaquin (levofloxacin), according to ... - International News Service,
KAI Pharmaceuticals, Inc. and Sankyo Company, Limited Enter Global ... Jan 9, 2006
...products on the Japanese market, including the antihypertensive Benicar® (olmesartan medoxomil) and the synthetic antibacterial agent Cravit® (levofloxacin). ... - Yahoo! News (press release)
(PRN) - Emerging Market for Omega-3 Fatty Acids Gains Ground ... ... Jan 24, 2006
Shows More Elderly Patients With Community-Acquired Pneumonia Recovered at Days 3 to 5 With AVELOX(R) (Moxifloxacin HCl) Compared to LEVAQUIN (Levofloxacin ... - Bolsamania.com,
New, virulent staph infection sparks health fears Jan 20, 2006
Writing in the November 2005 Annals of Emergency Medicine, Dr. Frazee says the man was discharged with a prescription for levofloxacin, a cousin of Cipro that ... - Pittsburgh Post Gazette,
Researchers find improved treatment for pneumonia in elderly Jan 24, 2006
The antibiotic moxifloxacin HCI has proved more effective in battling community-acquired pneumonia in patients 65 and older than levofloxacin, the antibiotic ... - San Antonio Business Journal,
E. Coli Defense Mechanism May Provide Key to Disrupting Bacteria ... Jan 16, 2006
In more severe cases of gastroenteritis, antibiotics such as erythromycin, clarithromycin, azithromycin ciprofloxacin, levofloxacin, gatifloxacin, or ... - Newsinferno.com,
Johnson & Johnson: Fourth Quarter and Year End 2005 Financial ... Jan 24, 2006
Inflammatory Diseases; TOPAMAX® (topiramate), an antiepileptic and a treatment for the prevention of migraine headaches; LEVAQUIN® (levofloxacin), an anti ... - PharmaLive.com (press release),
Other information
Indication
For the treatment of aausea and vomiting associated with cancer chemotherapy
Pharmacology
Palonosetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Palonosetron is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors.
Mechanism Of Action
Palonosetron is a selective serotonin 5-HT3 receptor antagonist. The serotonin 5-HT3 receptors are located on the nerve terminals of the vagus in the periphery and centrally in the chemoreceptor trigger zone of the area postrema. It is thought that chemotherapeutic agents produce nausea and vomiting by releasing serotonin from the enterochromaffin cells of the small intestine, and that the released serotonin then activates 5-HT3 receptors located on vagal efferents to initiate the vomiting reflex. Therefore Palonosetron works by blocking the reception of serotonin at these 5-HT3 receptors.
Drug Category
Antiemetics; ATC:A04AA
Brand Names/Synonyms
Aloxi; Onicit; Palonosetron; Raloxifene
Dosage Forms
Not Available
Absorption
Not Available
Interactions
-->Interactions for Palonosetron:
Palonosetron is eliminated from the body through both renal excretion and metabolic pathways.
Therefore, the potential for clinically significant drug interactions with palonosetron appears to be low.
Chemical IUPAC Name
Not Available
Chemical Formula
C19H24N2O
Half Life
Approximately 40 hours
Drug Type
Approved Drug
# Accession No
APRD00351
CAS Registry Number
119904-90-4