Alora: profile and news

2 -Adrenergic Receptor Genotype and Survival After Acute Coronary ...  Feb 14, 2006
...metabolic effects have been associated with -receptor antagonists as well as the 2 genetic variants we investigated, 3 and the effects of metoprolol may vary ... - Journal of American Medical Association (subscription),

KV Pharmaceutical Reports Record Revenues for Fiscal 2006 Third ...  Feb 7, 2006
This ruling positions us for exclusivity on two key dosage strengths of our generic metoprolol equivalent, pending FDA approval. ... - PR Newswire (press release),

Restarting hearts of all ages  Feb 15, 2006
The Carvedilol or Metoprolol European Trial (COMET) tested 3,029 patients from 15 European countries and 317 centers over a period of six years. ... - Saturday Evening Post,

Toprol XL uncertainty weighs heavy on AstraZeneca  Feb 3, 2006
But loss of a crucial patent infringement lawsuit for Toprol XL (metoprolol succinate) in the USA last month is giving AstraZeneca investors the jitters, and ... - Pharma Times (subscription),

SLEEPLESS IN NORTH AMERICA  Jan 31, 2006
I am 74. I take low-dose aspirin, metoprolol, Coumadin and an oral diabetes pill. My blood pressure and blood sugar are well-controlled. My problem? ... - Charlotte Sun-Herald,

Generics Erosion will Result in Slow Growth of Market to Treat ...  Feb 1, 2006
...blockers should spur near- term increased sales of carvedilol, GlaxoSmithKline's Coreg and Roche's Dilatrend, as well as metoprolol succinate, AstraZeneca's ... - PR Newswire (press release),

TOPROL-XL® (metoprolol succinate): AstraZeneca to appeal decision ...  Jan 18, 2006
...received a decision of Judge Rodney Sippel of the US District Court for the Eastern District of Missouri in litigation titled In Re Metoprolol Succinate Patent ... - Biotech Intelligence (press release),

Generics Erosion will Result in Slow Growth of Market to Treat ...  Feb 1, 2006
...blockers should spur near- term increased sales of carvedilol, GlaxoSmithKline's Coreg and Roche's Dilatrend, as well as metoprolol succinate, AstraZeneca's ... - PR Newswire (press release),

Toprol XL uncertainty weighs heavy on AstraZeneca  Feb 3, 2006
But loss of a crucial patent infringement lawsuit for Toprol XL (metoprolol succinate) in the USA last month is giving AstraZeneca investors the jitters, and ... - Pharma Times (subscription),

Medicines most likely aren't responsible for sleeplessness  Feb 2, 2006
I am 74. I take low-dose aspirin, metoprolol, Coumadin and an oral diabetes pill. My blood pressure and blood sugar are well-controlled. My problem? ... - SouthCoastToday.com,

FDA Grants Priority Review to PLAVIX(R) (Clopidogrel Bisulfate) ...  Jan 17, 2006
...therapy. In the COMMIT/CCS-2 (ClOpidogrel and Metoprolol in Myocardial Infarction Trial) trial, patients were followed for 28 days. ... - Boursorama,

Andrx Granted Summary Judgment for Generic Toprol-XL  Jan 18, 2006
...companies with respect to each company's abbreviated new drug applications (ANDA) for the generic version of Toprol-XL(R) (metoprolol succinate extended ... - Genetic Engineering News,

AstraZeneca’s patents on Toprol-XL invalidated  Jan 18, 2006
AstraZeneca said its patents on Toprol-XL extended release tablets, known generically as metoprolol succinate, were due to expire on Sept. 17 next year. ... - philly.com,

Patients' Genes Can Be Bad Medicine  Jan 12, 2006
These drugs included the antidepressant fluoxetine, the beta blocker metoprolol, the high blood pressure drug diltiazem and the anticoagulant warfarin. ... - Forbes

Amiodarone Plus Beta-Blocker Prevents ICD Shocks  Jan 11, 2006
...assessed the occurrence of ICD shocks in 412 patients who were randomized to receive amiodarone plus a beta-blocker (either metoprolol, carvedilol, or ... - Medscape (subscription)

Birth-control pills and libido: Study finds link  Jan 17, 2006
...breath. Beta blockers like atenolol, metoprolol and propranolol have been first choices for treating high blood pressure for decades. ... - SouthCoastToday.com,

AstraZeneca loses exclusive rights to drug  Jan 19, 2006
Toprol-XL extended release tablets, known generically as metoprolol succinate, is AstraZeneca's third-best-selling blockbuster, behind Nexium for heartburn and ... - philly.com,

Genes’ influence on common drugs may affect health-care quality ...  Jan 9, 2006
Among these drugs are fluoxetine (Prozacâ„¢), metoprolol (a beta-blocker), diltiazem (used to treat high blood pressure), and warfarin (an anticoagulant). ... - innovations report,

Culprit in breathing difficulties  Jan 15, 2006
Beta blockers such as atenolol, metoprolol and propranolol have been first choices for treating high blood pressure for decades. ... - Los Angeles Times,

KV Pharmaceutical Company Wins Summary Judgment in Patent ...  Jan 18, 2006
Company by AstraZeneca based on the Company's submission of ANDAs seeking approval to market generic formulations of Toprol-XL® (metoprolol succinate extended ... - Yahoo! News (press release)

KV Pharmaceutical Reports Record Revenues for Fiscal 2006 Third ...  Feb 7, 2006
This ruling positions us for exclusivity on two key dosage strengths of our generic metoprolol equivalent, pending FDA approval. ... - PR Newswire (press release),

Just see, before it catches you  Dec 9, 2005
Ergot used for headache and migraine, B-blockers (Atenolol, Propranolol, Metoprolol, Nadolol) used for cold control, Phenylpropanolamine (Ephedrine) (Allerest ... - GreaterKashmir.com (press release),

PHO impact seen in subsidised prescribing jump  Dec 5, 2005
Antibiotics filled the next two places followed by treatments for asthma (salbutamol and fluticasone) and raised blood pressure (metoprolol, quinapril and ... - Scoop.co.nz (press release),

New Scan Gives Doctors Better Picture of Heart  Dec 5, 2005
If your heart rate is greater than 65 beats per minute, you may be given some intravenous beta-blocker (metoprolol) to slow your heart rate. ... - KSDK,

Mixing Up Drugs with Similar Names Can Cause Potentially Deadly ...  Nov 28, 2005
The drugs are: ? TOPROL-XL® (metoprolol succinate) – AstraZeneca – a beta blocker used to treat high blood pressure, heart failure, and angina used to ... - Newsinferno.com,

FDA warns of risk from mixed-up prescriptions  Nov 27, 2005
Toprol-XL, also known by the generic name metoprolol succinate, which is for treating hypertension, chest pain and some kinds of heart failure. ... - Standard-Speaker,

Advocates fear drug-plan confusion  Nov 20, 2005
...with elder advocate Alice Corson, Townsend learned his annual costs for five drugs, including blood-thinning Warfarin and beta-blocker Metoprolol, would be ... - MaineToday.com,

AstraZeneca Provides Additional Support to Hurricane Victims  Nov 17, 2005
TURBUHALER® (budesonide inhalation powder), RHINOCORT AQUA® (budesonide), SEROQUEL® (quetiapine fumarate), TOPROL-XL® (metoprolol succinate), ZOLADEX ... - Yahoo! News (press release)

AstraZeneca Provides Additional Support to Hurricane Victims  Nov 17, 2005
TURBUHALER(R) (budesonide inhalation powder), RHINOCORT AQUA(R) (budesonide), SEROQUEL(R) (quetiapine fumarate), TOPROL-XL(R) (metoprolol succinate), ZOLADEX(R ... - PR Newswire (press release),

TOPROL-XL(R) (metoprolol succinate) US Patent Litigation  Sep 30, 2005
...announced that it had received confirmation that its pending litigation to enforce its patents associated with TOPROL-XL(R) (metoprolol succinate extended ... - PR Newswire (press release),

Clonidine taker wonders if vision loss is a concern  Oct 4, 2005
...omega-3 fatty acids. I take Toprol (metoprolol) for high blood pressure and would like to know if this is true. A Fish oil (source ... - Contra Costa Times,

Warning about drug mix-ups  Sep 29, 2005
The three drugs are: Toprol-XL, also known as metoprolol succinate (the South African trade name is Lopressor); Topamax, also known as topiramate; and Tegretol ... - Health24.com,

FDA warns of risk from mixed-up prescriptions  Sep 27, 2005
Toprol-XL, also known by the generic name metoprolol succinate, which is for treating hypertension, chest pain and some kinds of heart failure. ... - MSNBC

FDA Warns of Risk From Prescription Mix-Up  Sep 27, 2005
..._Toprol-XL, also known by the generic name metoprolol succinate, which is for treating hypertension, chest pain and some kinds of heart failure. ... - San Francisco Chronicle,

Plan B predicament has FDA in hot water  Sep 11, 2005
I checked online and found that metoprolol has a warning to contact the doctor immediately if you experience wheezing, shortness of breath or swelling of hands ... - Houston Chronicle,

(HUG) - DSM sells styrene-butadiene rubber business to Lion ...  Sep 30, 2005
...(PRN) - DTE Energy Subsidiary Gains FERC Approval; Closes Metro Energy Deal ... [+. PRN) - TOPROL-XL(R) (metoprolol succinate) US Patent Litigation ... [+. ... - Bolsamania.com,

Prescription drug mix-ups prompt FDA admonition  Sep 28, 2005
...â–  Toprol-XL, also known by the generic name metoprolol succinate, which is used to treat hypertension, chest pain and some kinds of heart failure. ... - Kansas City Star,

Doctors, Pharmacists Warned of Drug Mix-Ups  Sep 28, 2005
The drugs are Toprol-XL, Topamax, and Tegretol. Toprol-XL, generic name metoprolol succinate, treats hypertension, chest pain, and some kinds of heart failure. ... - All Headline News

Valley business week in review  Oct 3, 2005
...warned that mix-ups in prescriptions of three drugs with similar names but vastly different effects - Toprol-XL and its generic metoprolol succinate; Topamax ... - The Desert Sun,

Letter Warns About Drug Mix-Ups  Sep 28, 2005
The three drugs are: Toprol-XL, also known as metoprolol succinate; Topamax, also known as topiramate; and Tegretol, also known as carbamazepine. ... - HealthCentral.com

Sensitivity to beta blockers  Sep 11, 2005
I checked online and found that metoprolol has a warning to contact the doctor immediately if you experience wheezing, shortness of breath or swelling of hands ... - Los Angeles Times,

Best Treatments: Managing Heart Failure  Sep 24, 2005
Research has shown that beta blockers like carvedilol, bisoprolol and sustained-release metoprolol lower mortality by 30 percent or more. ... - Newsweek

Sleep aid Rozerem available soon  Sep 12, 2005
Can this medication cause these symptoms? Metoprolol is a beta blocker that helps prevent the heart from overworking. It can also lower blood pressure. ... - Charlotte Observer,

D. Drug and Laboratory Test Interactions

1. Accelerated prothrombin time, partial thromboplastin time, and platelet aggregation time; increased platelet count; increased factors II, VII antigen, VIII antigen, VIII coagulant activity, IX, X, XII, VII-X complex, II-VII-X complex, and beta-thromboglobulin; decreased levels of anti-factor Xa and antithrombin III, decreased antithrombin III activity; increased levels of fibrinogen and fibrinogen activity; increased plasminogen antigen and activity.

2. Increased thyroid-binding globulin (TBG) leading to increased circulating total thyroid hormone levels, as measured by protein-bound iodine (PBI), T₄ levels (by column or by radioimmunoassay) or T₃ levels by radioimmunoassay. T₃ resin uptake is decreased, reflecting the elevated TBG. Free T₄ and T₃ concentrations are unaltered. Patients on thyroid replacement therapy may require higher doses of thyroid hormone.

3. Other binding proteins may be elevated in serum, i.e., corticosteroid binding globulin (CBG), sex hormone-binding globulin (SHBG), leading to increased total circulating corticosteroids and sex steroids, respectively. Free hormone concentrations may be decreased. Other plasma proteins may be increased (angiotensinogen/renin substrate, alpha-1-antitrypsin, ceruloplasmin).

4. Increased plasma HDL and HDL₂ cholesterol subfraction concentrations, reduced LDL cholesterol concentration, increased triglyceride levels.

5. Impaired glucose tolerance.

6. Reduced response to metyrapone test.