Alinia: profile and news






Tampa Firm's Medication Has Enormous Potential As Hepatitis ...  Feb 24, 2006
Romark has been testing its diarrhea drug Alinia, approved for use against intestinal parasites, to combat a host of demons: Crohn's disease, a chronic ... - International News Service,

Romark to Develop Alinia (nitazoxanide) as New Treatment for ...  Jan 10, 2006
10, 2006 /PRNewswire/ -- Romark Laboratories announced that it is initiating US clinical development of Alinia(R) (nitazoxanide) tablets for treating chronic ... - PharmaLive.com (press release),

Romark Laboratories to Develop Alinia as New Treatment for Chronic ...  Jan 10, 2006
TAMPA, Fla. -- Romark Laboratories announced that it is initiating US clinical development of Alinia (nitazoxanide) tablets for treating chronic hepatitis C. ... - EndoNurse,

Plan to achieve self-sufficiency in rice will be launched next ...  Jan 16, 2006
...to achieve self-sufficiency in rice will be launched next year (Iranian year starts March 21) across the country, noted Monday, Faramarz Alinia, director of ... - MehrNews.com,

(PRN) - CYIOS Corporation Announces Record Quarterly and Annual ...  Jan 10, 2006
Awards ... [+. PRN) - Romark to Develop Alinia(R) (nitazoxanide) as New Treatment for Chronic Hepatitis C ... [+. PRN) - Spartan ... - Bolsamania.com,

Romark Advances Development of Alinia in Treating Clostridium ...  Dec 8, 2005
8 /PRNewswire/ -- Romark Laboratories announced another advance in its development of Alinia (nitazoxanide) for treating Clostridium difficile-associated ... - PR Newswire (press release),

Romark Advances Development of Alinia in Treating Clostridium ...  Dec 8, 2005
TAMPA, Fla., December 08, 2005 /PRNewswire/ -- Romark Laboratories announced another advance in its development of Alinia (nitazoxanide) for treating ... - PharmaLive.com (press release),

Development of Alinia in Treating Clostridium Difficile-Associated ...  Dec 8, 2005
...-- Romark Laboratories announced another advance in its development of Alinia (nitazoxanide) for treating Clostridium difficile-associated disease (CDAD). ... - EndoNurse,

Romark Completes Clinical Study of Alinia in Treating Clostridium ...  Nov 18, 2005
18 /PRNewswire/ -- Romark Laboratories announced completion of a prospective, randomized, double-blind clinical trial comparing Alinia (nitazoxanide) to ... - PR Newswire (press release),

(PRN) - Reinvented Bodies, Rejuvenated Lives: Who Will Win The $1 ...  Dec 8, 2005
Services ... [+. PRN) - Romark Advances Development of Alinia in Treating Clostridium Difficile-Associated Disease ... [+. PRN ... - Bolsamania.com,

(BMS) - Preapertura EE.UU. » Según las indicaciones de... [+]  Dec 8, 2005
...[+]. (PRN) - Blue Cross and Blue Shield of Florida Credit and Financial... [+. PRN) - Romark Advances Development of Alinia in Treating... [+. ... - Bolsamania.com,

Romark drug demonstrates efficacy in Clostridium difficile  Nov 21, 2005
Romark Laboratories has completed a trial evaluating its drug Alinia in treating hospitalized adults with Clostridium difficile-associated disease. ... - Pharmaceutical Business Review

(PRN) - NYFIX Appoints New Auditors, Announces Management ...  Nov 18, 2005
Denver ... [+. PRN) - Romark Completes Clinical Study of Alinia in Treating Clostridium Difficile-Associated Disease ... [+. PRN ... - Bolsamania.com,

Local firm's unique aid is a nice pill to swallow  Sep 15, 2005
The pharmaceutical company will donate up to $1-million worth of its gastrointestinal, anti-infective drug Alinia to public health authorities in the gulf ... - St. Petersburg Times,

Romark Laboratories to Distribute Alinia to Public Health ...  08 Sep 2005
8 /PRNewswire/ -- Romark Laboratories announced today it will donate up to $1 million of its gastrointestinal anti-infective drug, Alinia (nitazoxanide), to ... - PR Newswire (press release),

(PRN) - Pennsylvania Health Department Receives More Than $3 ...  08 Sep 2005
...[+]. (PRN) - Romark Laboratories to Distribute Alinia to Public Health Authorities in Gulf States Following Hurricane Katrina ... [+. ... - Bolsamania.com,

Romark Labs donates $1 million in drugs for Gulf states  08 Sep 2005
...gastrointestinal infections. Romark Laboratories said it would donate up to $1 million of the drug, Alinia (nitazoxanide). The drug ... - Tampa Bay Business Journal,

Romark Laboratories Announces Clinical Study Evaluating Alinia(R) ...  Aug 24, 2005
24 /PRNewswire/ -- Romark Laboratories has begun enrolling patients in a clinical trial evaluating Alinia (nitazoxanide) for treatment of mild to moderate ... - PR Newswire (press release),

Romark Laboratories Announces Clinical Study Evaluating Alinia for ...  Aug 24, 2005
TAMPA, Fla., August 24, 2005 /PRNewswire/ -- Romark Laboratories has begun enrolling patients in a clinical trial evaluating Alinia (nitazoxanide) for ... - PharmaLive.com (press release),

Romark Laboratories to begin study into Crohn's disease  Aug 25, 2005
Romark Laboratories has begun enrolling patients in a clinical trial evaluating its drug Alinia for treatment of mild to moderate active Crohn's disease in ... - Pharmaceutical Business Review

Use of Nitazoxanide As a New Therapeutic Option for Persistent ...  Aug 12, 2005
Antiprotozoal agents used in the management of persistent diarrhea include metronidazole (Flagyl*) and, more recently, nitazoxanide (Alinia[dagger]). ... - RedNova.com,

Class action suit possible over spraypark  Aug 24, 2005
...tortured,� said Melissa DeWall, noting that the medical bills included a brief hospital stay, multiple doctors visits and money for the antibiotic, Alinia. ... - Finger Lakes Times,

Cryptosporidiosis at New York Water Park Sickens a Baker's Dozen  Aug 22, 2005
The most common treatment for cryptosporidium infection is the drug Alinia (nitazoxanide), an antiparasitic drug that treats diarrhea caused by the organism. ... - MedPage Today,

Spraypark test results due today  Aug 19, 2005
In June, the US Food and Drug Administration approved a new drug in tablet form, Alinia, to treat the cryptosporidium infection. ... - Finger Lakes Times,

Carterville defends its title at Marion tourney  Aug 22, 2005
Ashton's two-run double in the fifth was the difference. Kaylie Siefert plated Alinia Brown in the seventh for an insurance tally. ... - Marion Daily Republican, <**results**>

Alinia Approved by FDA to Treat Cryptosporidium in Adults  Jun 27, 2005
Tampa, Fla., infozine - The US Food and Drug Administration (FDA) has approved Alinia® (nitazoxanide) tablets and oral suspension for treating diarrhea caused ... - Kansas City infoZine

Crypto Drug May Get Wider Application; Alinia Appears to Work on ...  Jun 27, 2005
Alinia appears to be effective against diarrhea caused by C.difficile, the bacteria responsible for antibiotic-associated diarrhea and colitis. ... - RedNova.com

FDA Approvals: Revatio, Xeloda, Alinia  Jun 23, 2005
On June 16, the FDA approved an expanded indication for nitazoxanide 500-mg tablets and 100-mg/5-mL oral solution (Alinia, made by Romark Laboratories ... - Medscape (subscription)

FDA Approves First-Ever Treatment for Adults, Teens with Diarrhea ...  Jun 16, 2005
...— The US Food and Drug Administration (FDA) has approved Alinia(R) (nitazoxanide ... The study also showed that Alinia was safe and well-tolerated by patients. ... - Drug Newswire (press release)

FDA Approves First-Ever Treatment for Adults, Teens with Diarrhea ...  Jun 16, 2005
TAMPA, Fla., June 16, 2005 /PRNewswire/ -- The US Food and Drug Administration (FDA) has approved Alinia(R) (nitazoxanide) tablets and oral suspension for ... - PharmaLive.com (press release)

FDA approves treatment for diarrhea caused by Cryptosporidium ...  Jun 19, 2005
The US Food and Drug Administration (FDA) has approved Alinia (nitazoxanide) tablets and oral suspension for treating diarrhea caused by Cryptosporidium parvum ... - News-Medical.net

FDA approves diarrhea drug  Jun 17, 2005
Having completed a prior review, the FDA has now extended its approval for Romark Laboratories' Alinia tablets and oral suspension for treating diarrhea caused ... - Pharmaceutical Business Review

Crypto Drug May Get Wider Application; Alinia Appears to Work on ...  12 Sep 2002
Alinia appears to be effective against diarrhea caused by C.difficile, the bacteria responsible for antibiotic-associated diarrhea and colitis. ... - RedNova.com,

Alinia Approved by FDA to Treat Cryptosporidium in Adults  12 Sep 2002
Tampa, Fla., infozine - The US Food and Drug Administration (FDA) has approved Alinia® (nitazoxanide) tablets and oral suspension for treating diarrhea caused ... - Kansas City infoZine,

FDA Approvals: Revatio, Xeloda, Alinia  Jun 23, 2005
On June 16, the FDA approved an expanded indication for nitazoxanide 500-mg tablets and 100-mg/5-mL oral solution (Alinia, made by Romark Laboratories ... - Medscape (subscription)

FDA Approves First-Ever Treatment for Adults, Teens with Diarrhea ...  Jun 16, 2005
...— The US Food and Drug Administration (FDA) has approved Alinia(R) (nitazoxanide ... The study also showed that Alinia was safe and well-tolerated by patients. ... - Drug Newswire (press release),

FDA Approves First-Ever Treatment for Adults, Teens with Diarrhea ...  Jun 16, 2005
TAMPA, Fla., June 16, 2005 /PRNewswire/ -- The US Food and Drug Administration (FDA) has approved Alinia(R) (nitazoxanide) tablets and oral suspension for ... - PharmaLive.com (press release),

FDA approves treatment for diarrhea caused by Cryptosporidium ...  Jun 19, 2005
The US Food and Drug Administration (FDA) has approved Alinia (nitazoxanide) tablets and oral suspension for treating diarrhea caused by Cryptosporidium parvum ... - News-Medical.net,

FDA approves diarrhea drug  Jun 17, 2005
Having completed a prior review, the FDA has now extended its approval for Romark Laboratories' Alinia tablets and oral suspension for treating diarrhea caused ... - Pharmaceutical Business Review


Other information


Indication
For the treatment of diarrhea in adults and children caused by the protozoa Giardia lamblia; For the treatment of diarrhea in children caused by the protozoa Cryptosporidium parvum

Pharmacology
Not Available

Mechanism Of Action
The antiprotozoal activity of nitazoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction which is essential to anaerobic energy metabolism. Studies have shown that the PFOR enzyme from Giardia lamblia directly reduces nitazoxanide by transfer of electrons in the absence of ferredoxin. The DNA-derived PFOR protein sequence of Cryptosporidium parvum appears to be similar to that of Giardia lamblia. Interference with the PFOR enzyme-dependent electron transfer reaction may not be the only pathway by which nitazoxanide exhibits antiprotozoal activity.

Drug Category
Antiparasitics

Brand Names/Synonyms
Alinia; BRN 1225475; DRG-0242; NITAZOXANIDE; Nitazoxanid; Nitazoxanida [Inn-Spanish]; Nitazoxanide; Nitazoxanide Metabolite; Nitazoxanide [Usan:Inn]; Nitazoxanidum [Inn-Latin]; Tizoxanide Glucuronide

Dosage Forms
Oral suspension; Tablet

Absorption
70%

Interactions
Interactions for Nitazoxanide:

Tizoxanide is highly bound to plasma protein (>99.9%). Therefore, caution should be used when administering nitazoxanide concurrently with other highly plasma protein-bound drugs with narrow therapeutic indices, as competition for binding sites may occur (e.g., warfarin). In vitro metabolism studies have demonstrated that tizoxanide has no significant inhibitory effect on cytochrome P450 enzymes. Although no drug-drug interaction studies have been conducted in vivo, it is expected that no significant interaction would occur when nitazoxanide is co-administered with drugs that either are metabolized by or inhibit cytochrome P450 enzymes.



Chemical IUPAC Name
[2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl]ethanoate

Chemical Formula
C12H9N3O5S

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00558

CAS Registry Number
55981-09-4

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