Alavert: profile and news






2004 Spring Allergy Capitals  06 Mar 2006
..."When prevention is not enough, allergy sufferers have the option of non-drowsy, 24-hour allergy medication, such as Alavert™ and Claritin®, that are ... - About - News & Issues,

Healthcare changes to take effect  Feb 23, 2006
Over-the-counter medications, such as Prilosec OTC, Claritin, Claritin-D and Alavert, will also be available through physician's prescription, according to the ... - Independent Collegian (subscription),

Keeping tabs on cold pills  11 Dec 2005
For the last six months, anything with pseudoephedrine — like Claritin-D, Alavert or Contac — has had to be asked for in a pharmacy. ... - WHAS 11.com (subscription),

Histamine blockers fight allergy symptoms  Dec 4, 2005
...of advances in research, several newer, second-generation antihistamines have been developed such as Zyrtec, Allegra, Claritin, Clarinex and Alavert that do ... - Daytona Beach News-Journal,

Saving Money On Prescription Drugs  Sep 28, 2005
...alternatives, Hunter says. Loratadine is the active ingredient in Claritin, Alavert, and some generic allergy medicines. The doctor's ... - FDA.gov

Drugs can help during allergy season  Sep 24, 2005
Newer over-the-counter antihistamines such as Claritin and Alavert seem to work better than other products and do not produce the drowsiness associated with ... - Stevens Point Journal,

Tons of online coupons waiting for you  Jul 22, 2005
Allow eight to 10 weeks for delivery. - Print out a form for a $6.50 refund on Alavert at www.alavert.com/Rebate_Form.pdf. To receive ... - Nashua Telegraph <**results**>

Anthem Blue Cross and Blue Shield to offer discounts on over-the ...  Jun 28, 2005
The medications included in this program are allergy medications Alavert, Claritin, and Loratidine; pain medications Advil, Motrin, Alleve, and other generic ... - Foster's Daily Democrat

Allergy medicine discounted on BCBS Web site  Jun 21, 2005
The site offers a $4 discount coupon for Alavert, 12-count capsules or more, and will add other coupons as manufacturing companies make them available, said ... - Wilson Daily Times (subscription)

Pollen attacking region's noses  Jun 17, 2005
For people with less severe symptoms, Shah recommends an over-the-counter medication such as Loratadine (Claritin, Alavert) or Benadryl. ... - Foster's Daily Democrat

The Patriot Ledger  Jun 21, 2005
My preferred regimen for treating the itch includes non-sedating Claritin (loratidine, Alavert) in the morning and sedating Benadryl (diphenhydramine) at ... - The Patriot Ledger,

Allergy medicine discounted on BCBS Web site  Jun 21, 2005
The site offers a $4 discount coupon for Alavert, 12-count capsules or more, and will add other coupons as manufacturing companies make them available, said ... - Wilson Daily Times (subscription),

Icky, yellow pine pollen coating everything in sight  Jun 23, 2005
For people with less severe symptoms, Shah recommends an over-the-counter medication such as Loratadine (Claritin, Alavert) or Benadryl. ... - Foster's Daily Democrat,

The Patriot Ledger  Jun 21, 2005
My preferred regimen for treating the itch includes non-sedating Claritin (loratidine, Alavert) in the morning and sedating Benadryl (diphenhydramine) at ... - The Patriot Ledger,

Ah, ah, ah-choo!  Jun 7, 2005
Several antihistamines are available over the counter, and some of the newer versions - such as Claritin and Alavert - don’t cause drowsiness as severely as ... - Gilroy Dispatch (subscription),

Tiny pills, big headache  Jun 6, 2005
Sudafed and some forms of Actifed, Advil, Alavert, Aleve, Benadryl, Claritin, Contact, Motrin, Theraflu and Tylenol are among more than 200 cough, cold, flu ... - Kalamazoo Gazette,

Doctors: Allergies are worse this year  21 May 2005
...on days when the pollen count is high; and trying an over-the-counter, non-sedating antihistamine, such as Claritin (generic name loratadine) and Alavert. ... - Bloomington Pantagraph

Pills clear allergies, wallets  Apr 23, 2005
The costs of the different drugs do differ. Alavert is a generic form of Claritin that is also available over the counter and is cheaper than Claritin. ... - Kansas.com

Learn To Enjoy Spring Despite Having Allergies  May 9, 2005
But more than half of spring allergy sufferers respond well to over-the-counter medications like Alavert, Benadryl and Claritin or the prescription medications ... - WRAL.com

Anti-Meth Law Inconveniencing Allergy Sufferers  Apr 28, 2005
Pharmacists recommend these five drugs that are still on store shelves: Claritin, Alavert, Benadryl, Tavist and Chlor-Trimeton. - WHO-TV

The truth about allergies  Apr 25, 2005
Antihistamines: "They're always good, but most produce drowsiness. So, active working people need a nonsedating medicine like Alavert," Boggs said. ... - Shreveport Times

Carroll Police Blotter  Apr 17, 2005
Shoplifting: A shift supervisor at the Rite Aid Pharmacy in the 3000 block of Gamber Road reported the theft of 34 packages of Claritin and Alavert about 5:30 ... - Baltimore Sun

Anti-Meth Law Inconveniencing Allergy Sufferers  28 Apr 2005
Pharmacists recommend these five drugs that are still on store shelves: Claritin, Alavert, Benadryl, Tavist and Chlor-Trimeton. - WHO-TV

Pills clear allergies, wallets  Apr 23, 2005
The costs of the different drugs do differ. Alavert is a generic form of Claritin that is also available over the counter and is cheaper than Claritin. ... - Kansas.com

The truth about allergies  Apr 25, 2005
Antihistamines: "They're always good, but most produce drowsiness. So, active working people need a nonsedating medicine like Alavert," Boggs said. ... - Shreveport Times

Treat Allergies Effectively  Apr 4, 2005
The symptoms can be treated by over-the-counter medications, such as Claritin and Alavert, which contain loratadine a non-drowsy antihistamine. ... - Omaha Channel.com

What's An Allergy Sufferer To Do?  Apr 6, 2005
1 allergy medicine people are buying at Marley Drug in Winston-Salem. Doug Marley suggests Clariten to his customers, followed by Alavert. ... - WXii 12.com

Carroll Police Blotter  Apr 17, 2005
Shoplifting: A shift supervisor at the Rite Aid Pharmacy in the 3000 block of Gamber Road reported the theft of 34 packages of Claritin and Alavert about 5:30 ... - Baltimore Sun

You're not ill, it's wheezin' season  Mar 12, 2005
...released.". Klemawesch suggests over-the-counter decongestants and antihistamines like Claritin or Alavert to alleviate symptoms. ... - St. Petersburg Times,

2004 Spring Allergy Capitals Identified  Mar 10, 2005
..."When prevention is not enough, allergy sufferers have the option of non-drowsy, 24-hour allergy medication, such as Alavert™ and Claritin®, that are ... - allergies.about.com

Allergens In the air  Mar 1, 2005
...allergens. These include long-acting, over-the-counter medications such as Alavert and Claritin. Swim for better breathing. The ... - Press-Enterprise (subscription),


Other information


Indication
For the relief of symptoms of seasonal allergic rhinitis, pruritus, reduction in the number of hives in patients with chronic idiopathic urticaria.

Pharmacology
Desloratadine is a long-lasting antihistamine. Desloratadine is a second-generation H1-receptor antagonist which has a selective and peripheral H1-antagonist action. Histamine is a chemical that causes many of the signs that are part of allergic reactions, for example, swelling of tissues. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be "activated," releasing other chemicals which produce the effects that we associate with allergy. Desloratadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of cells by histamine. Unlike most other antihistamines, Desloratadine does not enter the brain from the blood and, therefore, does not cause drowsiness.

Mechanism Of Action
Like other H1-blockers, Desloratadine competes with free histamine for binding at H1-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscle. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.

Drug Category
Antihistamines; Antihistamines; ATC:R06AX27

Brand Names/Synonyms
Aerius; Alavert; Clarinex; Clarinex Reditabs; Claritin; Claritin Reditabs; Descarboethoxyloratadine; Descarboethoxyoratidine; Desloratadine; Desloratadine [Usan]; Desloratidine; Loratadine; Sch 34117

Dosage Forms
SYRUP; TABLET

Absorption
Not Available

Interactions
-->Interactions for Desloratadine:

In two controlled crossover clinical pharmacology studies in healthy male (n=12 in each study) a nd female (n=12 in each study) volunteers, desloratadine 7.5 mg (1.5 times the daily dose) once daily was coadministered with erythromycin 500 mg every 8 hours or ketoconazole 200 mg every 12 hours for 10 days. In three separate controlled, parallel group clinical pharmacology studies, desloratadine at the clinical dose of 5 mg has been coadministered with azithromycin 500 mg followed by 250 mg once daily for 4 days (n=18) or with fluoxetine 20 mg once daily for 7 days after a 23 day pretreatment period with fluoxetine (n=18) or with cimetidine 600 mg every 12 hours for 14 days (n=18) under steady state conditions to normal healthy male and female volunteers. Although increased plasma concentrations (C max and AUC 0-24 hrs) of desloratadine and 3-hydroxydesloratadine were observed , there were no clinically relevant changes in the safety profile of desloratadine, as assessed by electrocardiographic parameters (including the corrected QT interval), clinical laboratory tests, vital signs, and adverse events.

Table 1
Changes in Desloratadine and 3-Hydroxydesloratadine Pharmacokinetics in Healthy Male and Female Volunteers
 
Desloratadine 3-Hydroxydesloratadine
 
C max AUC
0-24 hrs
C max AUC
0-24 hrs
Erythromycin
(500 mg Q8h)
+24% +14% +43% +40%
Ketoconazole
(200 mg Q12h)
+45% +39% +43% +72%
Azithromycin
(500 mg day 1,
250 mg QD × 4 days)
+15% +5% +15% +4%
Fluoxetine
(20 mg QD)
+15% +0% +17% +13%
Cimetidine
(600 mg Q12h)
+12% +19% -11%  -3%


Chemical IUPAC Name
Not Available

Chemical Formula
C19H19ClN2

Half Life
50 hours

Drug Type
Approved Drug

# Accession No
APRD00324

CAS Registry Number
100643-71-8

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