Alamast: profile and news

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Allergy medications: Know your options Jun 25, 2005
Crolom) is available in eyedrop form, as are slightly different mast cell inhibitors, including lodoxamide (Alomide), pemirolast (Alamast) and nedocromil ... - MayoClinic.com

Other information

Indication
For the prevention of itching of the eyes caused by allergies such as hay fever, and allergic conjunctivitis

Pharmacology
Pemirolast is used for the prophylactic treatment of itching of the eye associated with allergic conjunctivitis. Pemirolast potassium is a mast cell stabilizer that inhibits the in vivo Type I immediate hypersensitivity reaction. Pemirolast inhibits the antigen-induced release of inflammatory mediators (e.g., histamine, leukotriene C4, D4, E4) from human mast cells. Allergic reactions lead to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H₁-receptors, produces pruritis, vasodilatation, Pemirolast is a histamine H1 antagonist. It competes with histamine for the normal H₁-receptor sites on effector cells of blood vessels. It provides effective, temporary relief of watery and itchy eyes.

Mechanism Of Action
Pemirolast binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Pemirolast has also been observed to block antigen-stimulated calcium ion influx into mast cells. Pemirolast inhibits the chemotaxis of eosinophils into ocular tissue, and prevents inflammatory mediator release from human eosinophils.

Drug Category
Anti-allergic Agents; Ophthalmics; Antipruritics; Histamine Antagonists

Brand Names/Synonyms
Alamast; Pemirolast; Pemirolast Potassium; Pemirolastum [Inn-Latin]; Pemiroplast Potassium

Dosage Forms
Ophthalmic Solution

Absorption
Not Available

Interactions
-->Interactions for Pemirolast:

No specific information available.

Chemical IUPAC Name
10-methyl-4-(2H-tetrazol-5-yl)-2,6-diazabicyclo[4.4.0]deca-1,3,7,9-tetraen-5-one

Chemical Formula
C10H8N6O

Half Life
4.5 hours (Ophthalmic)

Drug Type
Approved Drug

# Accession No
APRD00394

CAS Registry Number
100299-08-9