Aggrenox: profile and news

A Nation of Guinea Pigs Feb 28, 2006
18,500-person study. The drug regimen, known as Aggrenox, was being tested for its ability to forestall a second stroke. SP Kalantri ... - CorpWatch.org,

‘Nation of guinea pigs’? Mar 4, 2006
...prevention drug. The drug regimen, known as Aggrenox, was apparently tested for its ability to forestall a second stroke. There ... - Hindustan Times,

Harry Rush Jan 22, 2006
...to $329.79. Lipitor for cholesterol, $45; Niaspan for cholesterol, $161.20; Aggrenox to prevent another stroke, $123.59. Atenolol ... - Richmond Times Dispatch,

Most Extensive Thromboembolic Disease Clinical Trial Program ... Jan 29, 2006
Boehringer Ingelheim has a lot of experience in this area with our established products for prevention or emergency treatment of stroke, Aggrenox® and Actilyse ... - Medical News Today (press release),

Seniors pleasantly surprised by plan's low drug costs Jan 24, 2006
John, from Muskogee, Okla., who takes two drugs (Aggrenox and Synthroid), would save $300 a year by enrolling in his state's Part D plan. ... - NorthJersey.com,

New advances in the care of stroke patients Oct 10, 2005
Numerous blood thinners, called antiplatelet agents, have been used for years. They include aspirin, Plavix, and Aggrenox. These ... - Staten Island Advance, <**results**>

Strokes can be prevented if warning signs are heeded Jul 4, 2005
Treatment after ministrokes could include surgery to remove blockages, and drugs to reduce the tendency of blood to clot, such as Plavix and Aggrenox. ... - Naples Daily News (subscription),

NICE Recommends Aggrenox (dipyridamol) as First Line Treatment for ... Jun 6, 2005
...issued by the National Institute for Health and Clinical Excellence (NICE) in England and Wales has recommended the use of Aggrenox®/ Asasantin® retard ... - PharmaLive.com (press release),

Ministrokes deserve more attention from patients, doctors Jun 26, 2005
Treatment after ministrokes could include surgery to remove blockages and drugs such as Plavix and Aggrenox to reduce the tendency of blood to clot. ... - Pioneer Press,

Brain Attack A Look at Stroke Prevention and Treatment May 13, 2005
Antiplatelet drugs, such as aspirin, Plavix (clopidogrel), Ticlid (ticlopidine), and Aggrenox (aspirin and dipyridamole), prevent clotting by decreasing ... - FDA.gov

Stroke units offer support for patients, families Feb 28, 2005
The use of anti-platelet agents (blood thinners) such as aspirin, Coumadin, Plavix and Aggrenox has reduced the risk of secondary strokes in the patients. ... - Staten Island Advance,

Other information

Indication
For as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement and also used in prevention of angina

Pharmacology
Dipyridamole, a non-nitrate coronary vasodilator that also inhibits platelet aggregation, is combined with other anticoagulant drugs, such as warfarin, to prevent thrombosis in patients with valvular or vascular disorders. Dipyridamole is also used in myocardial perfusion imaging, as an antiplatelet agent, and in combination with aspirin for stroke prophylaxis.

Mechanism Of Action
Dipyridamole likely inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor of platelet function. This elevation in cAMP blocks the release of arachidonic acid from membrane phospholipids and reduces thromboxane A2 activity. Dipyridamole also directly stimulates the release of prostacyclin, which induces adenylate cyclase activity, thereby raising the intraplatelet concentration of cAMP and further inhibiting platelet aggregation.

Drug Category
Vasodilator Agents; Vasodilator Agents; ATC:B01AC07

Brand Names/Synonyms
Aggrenox; Agilease; Anginal; Apo-Dipyridamole Fc; Apo-Dipyridamole Sc; Apricor; Cardioflux; Cardoxil; Cardoxin; Chilcolan; Cleridium; Cleridium 150; Coribon; Coridil; Coronarine; Corosan; Coroxin; Curantyl; Dipiridamol; Dipyridamine; Dipyridamol; Dipyridamole; Dipyridamole, Pharma; Dipyridan; Dipyudamine; Dypyridamol; Gulliostin; Iv Persantine; Justpertin; Kurantil; Natyl; Novo-Dipiradol; Peridamol; Permiltin; Persantin; Persantine; Piroan; Prandiol; Prandiol 75; Protangix; RA 8; RA-8; Stenocardil; Stenocardiol; Stimolcardio; Usaf Ge-12

Dosage Forms
tablets

Absorption
70%

Interactions
Interactions for Dipyridamole:

No pharmacokinetic drug-drug interaction studies were conducted with PERSANTINE® (dipyridamole USP) Tablets. The following information was obtained from the literature.

Adenosine: Dipyridamole has been reported to increase the plasma levels and cardiovascular effects of adenosine. Adjustment of adenosine dosage may be necessary.

Cholinesterase Inhibitors: Dipyridamole may counteract the anticholinesterase effect of cholinesterase inhibitors, thereby potentially aggravating myasthenia gravis.

Chemical IUPAC Name
2-[[3-[bis(2-hydroxyethyl)amino]-5,10-bis(1-piperidyl)-2,4,7,9-tetrazabicyclo[4.4.0]deca-2,4,7,9,11-pentaen-8-yl]-(2-hydroxyethyl)amino]ethanol

Chemical Formula
C24H40N8O4

Half Life
40 minutes

Drug Type
Approved Drug

# Accession No
APRD00360

CAS Registry Number
58-32-2