Aggrastat: profile and news






Thrombolytic Treatment Before Stenting Linked to Increased ...  Feb 14, 2006
...in mortality for patients pre-treated with glycoprotein IIb/IIIa inhibitors such as ReoPro (abciximab), Integrilin (eptifibatide), and Aggrastat (tirofiban). ... - MedPage Today,

Merck Announces Strong Full-Year and Fourth-Quarter 2005 Earnings ...  Jan 31, 2006
Other reported products comprise: AGGRASTAT, ARCOXIA, CANCIDAS, COSOPT, CRIXIVAN, EMEND, INVANZ, MAXALT, PRIMAXIN, PROPECIA, PROSCAR, STOCRIN, TIMOPTIC ... - TMCnet

Stent patients go home sooner if wrist artery used  Nov 13, 2005
...and Sanofi-Aventis . Their drug ReoPro competes with Merck & Co.'s similar anti-clot medicine Aggrastat and Schering-Plough Corp.'s Integrilin. ... - Reuters AlertNet,

Merck Announces Initial Steps In Global Restructuring Program  Nov 28, 2005
SINGULAIR (Respiratory) $2.9 to $3.2 billion Other reported products* $5.9 to $6.2 billion * Other reported products comprise: AGGRASTAT, ARCOXIA, CANCIDAS ... - Business Wire (press release),

Guilford Pharmaceuticals Stockholders Vote to Approve MGI PHARMA ...  Sep 29, 2005
...markets two commercial products, Gliadel(R) wafer (polifeprosan 20 with carmustine implant), for the treatment of brain cancer, and Aggrastat(R) injection ... - PR Newswire (press release),

Guilford Pharmaceuticals Stockholders Vote to Approve MGI PHARMA ...  Sep 29, 2005
...two commercial products, Gliadel® wafer (polifeprosan 20 with carmustine implant), for the treatment of brain cancer, and Aggrastat® injection (tirofiban ... - Yahoo! News (press release)

Merck to invest $15 mn to beef up marketing  Sep 27, 2005
...product of Merck & Co in India. Aggrastat, a cardiovascular drug, is to be launched soon. Though these products are not covered ... - Business Standard,

ELISA II trial, better results with triple antiplatelet pre ...  Sep 10, 2005
...designed to compare dual antiplatelet, Aspirin and Clopidogrel 600 mg, with triple antiplatelet, Aspirin, Clopidogrel 300 mg and Tirofiban ( Aggrastat, a GP IIb ... - Xagena.it,

ESC: In High Risk Acute Coronary Syndrome, Three Drugs May Outdo ...  Sep 6, 2005
6-The addition of Aggrastat (tirofiban) to a standard regimen of aspirin and Plavix (clopidogrel) appears to benefit patients with non-ST segment elevation ... - MedPage Today,

MGI PHARMA and Guilford Pharmaceuticals Announce Expiration of the ...  Sep 1, 2005
...commercial products, Gliadel(R) wafer (polifeprosan 20 with carmustine implant), for the treatment of high grade malignant gliomas, and Aggrastat(R) injection ... - Genetic Engineering News,

Guilford Pharmaceuticals to Announce Second Quarter 2005 Financial ...  Aug 2, 2005
Presently, Guilford markets two commercial products, GLIADEL® Wafer, for the treatment of brain cancer, and AGGRASTAT® Injection, a glycoprotein GP IIb/IIIa ... - Yahoo News (press release)

Guilford Pharmaceuticals to Announce Second Quarter 2005 Financial ...  Aug 2, 2005
Presently, Guilford markets two commercial products, GLIADEL(R) Wafer, for the treatment of brain cancer, and AGGRASTAT(R) Injection, a glycoprotein GP IIb ... - PharmaLive.com (press release)

MSD Pharma commences Indian operations  Jul 22, 2005
Dr. Naveen Rao, Medical Director, MSD Pharmaceuticals India, said that the company would be launching two products Aggrastat and Zienam in the third quarter of ... - India Infoline.com

Merck plans major R&D investments on comeback  Jul 24, 2005
...would commence its marketing operations by launching two of its life-saving drugs — Zienam (a beta-lactam anti-biotic) and Aggrastat (a cardiovascular drug ... - Economic Times

MGI PHARMA to Acquire Guilford Pharmaceuticals  Jul 21, 2005
In addition, if Aggrastat(R) injection is not divested by Guilford prior to closing of this transaction, MGI PHARMA plans to continue these divestiture efforts ... - Business Wire (press release)

MGI Pharma to Buy Guilford Pharmaceuticals  Jul 21, 2005
Guilford's Aggrastat Injection, a heart attack treatment, hasn't lived up to its sales expectations and Guilford has been trying to unload it as part of a ... - RedNova.com

Merck re-enters India; product launches in pipeline  Jul 22, 2005
By August, the company intends to launch two of its life saving drugs, Zienam (a beta-lactam anti-biotic) and Aggrastat (a cardiovascular drug), he said. ... - Hindu

Merck returns to India  Jul 22, 2005
Rao said the company would initially market two products, Aggrastat aimed at patients with unstable angina and Zienam meant for treating serious infections in ... - Reuters

Merck returns to India  Jul 22, 2005
...stake. This time around MSD Pharma will make a start with two drugs, Aggrastat for unstable angina and Zienam, an antibiotoc. Both ... - Moneycontrol.com

Merck re-enters Indian market  Jul 22, 2005
...and conducive business environment in India, the company will first introduce Zienam (a broad spectrum beta-lactam anti-biotic) and Aggrastat (a cardiovascular ... - Hindu

Merck returns to India via own subsidiary  Jul 22, 2005
..."By August, MSD intends to launch two of its life saving drugs — Aggrastat (which prevents cardiac ischemic events) and Zienam (an antibiotic aimed at ... - Times of India

Merck re-enters India with $15 mn investment:-  Jul 22, 2005
The company will begin its operations by launching two of its products Aggrastat - a platelet aggregation inhibitor used to treat cardiac complications - and ... - Webindia123

Global pharmaceutical giant Merck & Co has announced its comeback ...  Jul 24, 2005
Tauro said here. Life saving drugs, Zienam (a beta-lactam anti-biotic) and Aggrastat (a cardiovascular drug), he said. Tauro said ... - India Daily

MGI Pharma aims to buy Guilford  Jul 22, 2005
...million owed to the Paul Royalty Fund. MGI plans to sell Aggrastat, a Guilford treatment for a heart illness, to pay the Paul fund. - Pioneer Press

Merck Announces Second-Quarter 2005 Earnings Per Share (EPS) of 33 ...  Jul 21, 2005
SINGULAIR (Respiratory) $2.9 to $3.2 billion Other reported products* $5.9 to $6.2 billion *Other reported products comprise: AGGRASTAT, ARCOXIA, CANCIDAS ... - Business Wire (press release) <**results**>

RN-Emerg - Emerg Nurses Reference Guide  Jun 26, 2005
Automatic med calculators for the following meds are included: Aggrastat, amiodarone, ventolin, bretylium, diltiazem, dobutamine, dopamine, epinephrine ... - Free-Press-Release.com (press release)


Other information


Indication
For treatment, in combination with heparin, of acute coronary syndrome, including patients who are to be managed medically and those undergoing PTCA or atherectomy.

Pharmacology
Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. When administered intravenously, tirofiban inhibits ex vivo platelet aggregation in a dose- and concentration-dependent manner. When given according to the recommended regimen, >90% inhibition is attained by the end of the 30-minute infusion. Tirofiban has been recently shown in patients with unstable angina to reduce ischemic events at 48 hours following infusion when compared to standard heparin therapy.

Mechanism Of Action
Tirofiban is a reversible antagonist of fibrinogen binding to the GP IIb/IIIa receptor, the major platelet surface receptor involved in platelet aggregation. Platelet aggregation inhibition is reversible following cessation of the infusion of Tirofiban.

Drug Category
Fibrinolytic Agents; Platelet Aggregation Inhibitors; ATC:B01AC17

Brand Names/Synonyms
AGG; Aggrastat; Tirofiban; Tirofiban [Ban:Inn]

Dosage Forms
LIQUID; SOLUTION

Absorption
Not Available

Interactions
Interactions for Tirofiban:

AGGRASTAT has been studied on a background of aspirin and heparin.

The use of AGGRASTAT, in combination with heparin and aspirin, has been associated with an increase in bleeding compared to heparin and aspirin alone (see



Chemical IUPAC Name
2-butylsulfonylamino-3-[4-[4-(4-piperidyl)butoxy]phenyl]-propanoic acid

Chemical Formula
C22H36N2O5S

Half Life
2 hours

Drug Type
Approved Drug

# Accession No
APRD00304

CAS Registry Number
144494-65-5

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