Adipex-P: profile and news

Lannett receives FDA approval for generic obesity drug Apr 22, 2005
Generic drug manufacturer Lannett Company has received approval from the FDA to market a copycat version of Gate Pharmaceuticals' obesity drug Adipex-P. ... - Pharmaceutical Business Review

Lannett Receives FDA Approval for Phentermine; Company to Launch ... Apr 21, 2005
Phentermine Hydrochloride is indicated for the short-term management of obesity and is the generic equivalent of Adipex-P(R), marketed by Gate Pharmaceuticals ... - Business Wire

Buy Discount Phentermine, Adipex, and Ionamin Online in the ... Apr 4, 2005
...political pressure even though their patients would benefit tremendously from taking Phentermine or one of its name brand counterparts like Adipex P or Ionamin ... - Khalsa News Network,

Other information

Indication
Indicated for the treatment and management of obesity.

Pharmacology
Phentermine is indicated in the management of exogenous obesity as a short term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction. Phentermine hydrochloride is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for.

Mechanism Of Action
Phentermine is an amphetamine that stimulates neurons to release or maintain high levels of a particular group of neurotransmitters known as catecholamines; these include dopamine and norepinephrine. High levels of these catecholamines tend to suppress hunger signals and appetite. Phentermine (through catecholamine elevation) may also indirectly affect leptin levels in the brain. It is theorized that phentermine can raise levels of leptin which signal satiety. It is also theorized that increased levels of the catecholamines are partially responsible for halting another chemical messenger known as neuropeptide Y. This peptide initiates eating, decreases energy expenditure, and increases fat storage.

Drug Category
Adrenergic Agents; Appetite Depressants; Central Nervous System Agents; Anorexigenic Agents; Stimulants; ATC:A08AA01; ATC:C01CA11

Brand Names/Synonyms
Adipex-P; Alpha,Alpha-Dimethylphenethylamine; Duromine; Fastin; Inoamin; Ionamin; Linyl; Lipopill; Lonamin; Mirapront; Normephentermine; Obenix; Obestin-30; Oby-Trim; Omnibex; Ona Mast; Ona-Mast; Phentercot; Phentermine; Phentermine Hcl; Phentermine Hydrochloride; Phentermine Resin 30; Phentride; Pre-Sate; Pro-Fast; Rcra Waste Number P046; Teramine; Tora; Uritone; Wilpo; Wyamine Sulfate; Zantryl

Dosage Forms
CAPSULE

Absorption
Phentermine is rapidly absorbed after oral ingestion.

Interactions
Interactions for Phentermine:

Concomitant use of alcohol with phentermine hydrochloride may result in an adverse drug interaction.

Chemical IUPAC Name
2-methyl-1-phenyl-propan-2-amine

Chemical Formula
C10H15N

Half Life
16 to 31 hours

Drug Type
Approved Drug

# Accession No
APRD00093

CAS Registry Number
122-09-8