Adalat: profile and news






Indigenous health group backs kava ban  07 Mar 2006
A national Aboriginal health group has welcomed moves by the federal Indigenous Affairs Minister to ban kava. Henry Councillor is ... - ABC Regional Online,

VANUATU: Fiji To Be Grilled By MSG Countries During Emergency ...  07 Mar 2006
...“Fiji has had problems with Vanuatu on kava exports. At the same time, Fiji has ongoing differences with Papua New Guinea on exports of corned beef to Fiji. ... - Pacific Magazine,

Police swoop on record NT kava haul  Mar 4, 2006
By REBEKAH CAVANAGH. NT POLICE have seized what is believed to be a record haul of kava in the Territory. About 350kg of kava -- with ... - NEWS.com.au,

Police make $450,000 kava bust  Mar 4, 2006
The kava was divided into 9,000 deal bags that police believe were going to be sold in remote Aboriginal communities. Detective ... - ABC Online,

Three arrested for importing Kava  Mar 3, 2006
A Man and a woman have been arrested in the Northern Territory for allegedly possessing 360kg of the drug kava. A 38-year-old man ... - Melbourne Herald Sun,

Warrior joins Kava session  Mar 3, 2006
Bati manager Rusiate Ratakele said Wiki's love for kava drove him to the camp where he conveyed some constructive tips to coach Jo Rabele. ... - Fiji Times,

Kava farmers seek State assistance  Mar 3, 2006
Fiji Kava Council chairman, Ratu Josateki Nawalowalo said they needed $2million to set up farmers and facilitate the necessary machinery and technology. ... - Fiji Times,

REGION: New Kava Toxicology Report May Help Lift Europe Ban  Feb 28, 2006
Kava producing countries in the Pacific will incur an accumulated loss of US$1.2-billion in revenue by the end of 2006 due to the kava ban imposed by European ... - Pacific Magazine,

Europe may lift kava ban: Council  Mar 1, 2006
THE ban on kava exports by Europe's leading herbal medicine markets may be lifted by the end of the year, said the International Kava Executive Council. ... - Fiji Times,

Stakeholders to combat kava ban  Feb 28, 2006
THE Pacific region has lost $US1.2billion ($F2.1billion) since the kava ban which was imposed by Germany six year ago. Chairman ... - Fiji Times,

Vanuatu opposition rallies over kava policy, prepares motion ...  Mar 1, 2006
...who was dumped as Agriculture minister this week, says a number of government backbenchers are dissatisfied with the government’s policy on kava exports and ... - Radio New Zealand International,

Vanuatu leaders in dispute over kava exports  Feb 26, 2006
A dispute has broken out within Vanuatu's government over the marketing and export of kava. A unilateral order has been made by ... - Radio New Zealand,

Pacific: Kava producers welcome anti-cancer findings  Feb 22, 2006
Pacific kava producers are ecstatic, after the findings of new scientific research suggested kava may prevent some types of cancer, including leukemia and ... - Port Vila Presse,

International kava body to meet in Suva  Feb 21, 2006
By The Independent. The International Kava Executive Council will meet in Suva at the end of the month to discuss the removal of the kava ban in Europe. ... - Port Vila Presse,

Vanuatu Commodities Marketing Board monopoly on kava detrimental ...  Feb 22, 2006
Barak Sope in a letter to the president of the chamber of commerce, Joseph Jacobe says that the recent VCMB board decision regarding the kava trade has the ... - Port Vila Presse,

Author Alex Kava can't handle gore  Feb 17, 2006
Author Alex Kava can capture the intrigue of a serial killer's mission in just a few words, but she says her subject matter makes her stomach turn. ... - Ninemsn,

Drama-faculty newcomer, a veteran of film and television, is ...  Mar 4, 2006
Caroline Kava has played a number of challenging roles in her career, but perhaps none has been more challenging than or as satisfying as her latest - as the ... - Winston-Salem Journal,

Kava council welcomes cancer cure news  Feb 14, 2006
The Fiji Kava Council (FKC) has welcomed a scientific finding describing kava as a cure for two types of cancer as a blessing and "Mana" for Pacific Island ... - fijilive.com,

Kava's book picked for reading program  Feb 15, 2006
Editor. There's probably not much of a mystery for Alex Kava fans as to why one her novels was chosen for One Book One Nebraska. ... - Columbus Telegram,

Study finds kava cures two types of cancer  Feb 14, 2006
A NEW research has found that kava (yaqona) is a cure for two types of cancer. ... Dr Tabudravu said the discovery could boost kava production and its export. ... - Fiji Times,

Research in Europe claims kava can cure some forms of cancer  Feb 14, 2006
New research in Scotland and Luxembourg has found that kava is a cure for two types of cancers. The Fiji Times reports that researchers ... - Radio New Zealand International,

FIJI: Concerns Over Tough Quality Control For Imported Kava  Feb 15, 2006
Pacific Beat/Radio Australia Online reports that Fiji's ongoing concerns over quality control of kava imported from neighbouring countries have prompted it to ... - Pacific Magazine,

Kava kava, echinacea, and ginseng, should they be FDA Approved?  Feb 18, 2006
Kava Kava should not be FDA approved. Kava Kava is believed to control anxiety, depression, alleviate symptoms of menopause and ... - ProgressiveU.org,

'Convince Europe to lift kava ban'  Feb 15, 2006
RESEARCHERS who discovered that kava is a cure for two types of cancer should convince Europe to lift its ban, says Agriculture Minister Ilaitia Tuisese. ... - Fiji Times,

Vanuatu PM Lini removes Fisheries and Quarantine from Minister ...  Feb 27, 2006
And the source went on to say that the ministry of agriculture had made known its view about giving the kava monopoly to Vanuatu Commodities Marketing Board ... - Port Vila Presse,

All natural, pure organic, 100-per-cent mayhem  Mar 5, 2006
Throw in all sorts of exotic sounding things, and don't forget trendy things like kava-kava and ginseng that have no place in a body-care product. ... - Ottawa Citizen,

FIJI: Study Finds Kava Prevents Two Types Of Cancer  Feb 14, 2006
The Fiji Times Online reports that a new research has found that kava (yaqona) is a cure for two types of cancer. Researchers at ... - Pacific Magazine,

Book Briefs | Mysteries  Feb 28, 2006
Ruiz. This is Kava's fifth novel involving FBI profiler Maggie O'Dell, who tries to solve not one but two serial killer cases. In ... - Miami Herald,

Citation process makes a mess of parking fines  Feb 27, 2006
They have the final say, so what's the point?". De Anza journalism instructor Brad Kava was ticketed for not having a permit, though he did have one. ... - La Voz Weekly,

Best-selling author plans stop in Blair  Feb 17, 2006
...murder of young boys in Nebraska, the suicide deaths of cult followers, or the decapitation of young women and the slaying of Catholic priests, Kava has done ... - Blair Enterprise Publishing,

Mystery author coming to town  Feb 5, 2006
WALLINGFORD — About a third of the way into Alex Kava’s new thriller “A Necessary Evil,� a character suggests that on the way from West Haven to ... - Record-Journal,

Windjammers earn solid times in state meet  Feb 24, 2006
Presque Isle 6. 200 medley relay — 9, Camden Hills (Jennifer Grinnell, Squibb, Sarah Doubleday, Amanda Kava), 2:12.25. In the ... - knox.VillageSoup.com,

Can a vaccine help smokers kick the habit?  Feb 10, 2006
Q: I have heard about the herbal supplement kava and that it can help people relax. ... Kava is now being used here in beverages, such as juices, teas and coffees. ... - Salem News,

Vanuatu Chamber of Commerce approves 10 Noble Kavas  Feb 5, 2006
The Vanuatu Chamber of Commerce (VCCI) has selected 10 out of a total of 82 varieties of kava for market following latest research done on Vanuatu kava by the ... - Port Vila Presse,

Eagle Family Foods looking to refinance debt  Mar 3, 2006
In addition to its Eagle and other brands of evaporated and sweetened condensed milk, it sells Cremora and other brands of nondairy creamer, Kava instant coffee ... - Columbus Business First,

Benzene Redux: This Time It's Soda  Mar 3, 2006
February 10, 1990:1. Ruth Kava, Ph.D., RD, is Director of Nutrition at the American Council on Science and Health (ACSH.org, HealthFactsAndFears.com). - American Council on Science and Health,

Local bands fighting the odds of making it big  Mar 1, 2006
By Brad Kava. Those ... miracle. Read Brad Kava's complete Pop Music column in the Eye entertainment guide inside tomorrow's Mercury News. - San Jose Mercury News,

Ministry concerned with Sanction Threats  Feb 20, 2006
PNG Trade and Industry Minister, Paul Tiensten has confirmed that he is contemplating sanctions, after a consignment of PNG Kava was rejected entry into Fiji ... - Fijivillage,

PNG May Impose Sanctions Against Fiji  Feb 20, 2006
...country. The dispute results from the decision to reject a consignment of PNG Kava as it did not meet quarantine standards. Earlier ... - Fijivillage,

Caviar, Cristal for Super Bowl crowd  Feb 4, 2006
It seems like every venue wants something different and to put their best foot forward," said Mark Kava, vice president of sales and operations at Chicago Beef ... - Daily Review Online,

Kailua debris dilemma not over  Feb 3, 2006
...from a Mainland owner. Michele Kava, with The Rock Man, said Martin's left more concrete than was agreed upon. Martin's got the ... - Honolulu Advertiser,

Islanders await their messiah to return with the Navy  Feb 4, 2006
...the natives on these isolated islands were farmers and fishermen who created a culture based on polygamy, ritual dancing and the drinking of kava, a powerfully ... - Fort Wayne Journal Gazette,

Westside emerges with 21-5A crown  Feb 3, 2006
The Cardinals even knocked the ball out of Kava's hands, but she retrieved it just short of the half-court stripe, found teammate Sydney Colson cutting to the ... - Houston Chronicle,

Happy Jon Frum Day to all  Feb 14, 2006
...seems the natives of these islands once were farmers and fishermen whose culture was based on polygamy, ritual dances and the consumption of kava, a moonshine ... - Enid News & Eagle,

Sleep treatments rise to the occasion  Feb 26, 2006
...hard evidence supports the use of other non-prescription options, including melatonin supplements and extracts of valerian, chamomile and kava kava, according ... - USA Today

Wedding Present has Bay Area engagement  Feb 22, 2006
By Brad Kava. Though ... com. Read Brad Kava's complete pop music column in the Eye entertainment guide inside tomorrow's Mercury News. - San Jose Mercury News,


Other information


Indication
For the management of vasospastic angina, chronic stable angina and hypertension

Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.

Mechanism Of Action
Nifedipine inhibits the influx of extracellular calcium through myocardial and vascular membrane pores by physically plugging the channel. The decrease in intracellular calcium inhibits the contractile processes of smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

Drug Category
Tocolytic Agents; Vasodilator Agents; Calcium Channel Blockers; Dihydropyridines; ATC:C08CA05

Brand Names/Synonyms
Adalat; Adalat 10; Adalat 20; Adalat 5; Adalat Cc; Adalat Cr; Adalat Crono; Adalat Ft; Adalat Gits; Adalat Gits 30; Adalat La; Adalat Lp; Adalat Oros; Adalat Pa; Adalat Retard; Adalate; Adapine; Adapress; Alat; Aldipin; Alfadal; Alonix; Alonix S; Alpha-Nifedipine Retard; Angipec; Anifed; Anpine; Apo-Nifed; Aprical; BAY 1040; Bay a 1040; Bay-a 1040; Bonacid; CCRIS 6074; Calcibloc; Calcigard; Calcilat; Camont; Cardifen; Cardilat; Cardilate; Cardionorm; Chronadalate; Chronadalate Lp; Citilat; Coracten; Coral; Cordafen; Cordaflex; Cordalat; Cordicant; Cordilan; Cordipin; Corinfar; Corotrend; Corynphar; Depin; Dignokonstant; Dilafed; Dilcor; Dipinkor; Duranifin; Ecodipi; Ecodipin; Ecodipin E; Fedcor; Fedcor Retard; Fenamon; Fenamon Sr; Fenihidin; Fenihidine; Glopir; Hadipin; Hexadilat; Introcar; Kordafen; Macorel; Megalat; Myogard; N1fedilat; Nedipin; Nicardia; Nifangin; Nifar; Nifdemin; Nifebene; Nifecard; Nifecor; Nifedepat; Nifedicor; Nifedin; Nifedine; Nifedipine; Nifedipine Retard; Nifedipres; Nifedirex Lp; Nifelan; Nifelat; Nifelat Q; Nifelate; Nifensar Xl; Nificard; Nifidine; Nifipen; Niphedipine; Orix; Oxcord; Pidilat; Procardia; Procardia Xl; Sepamit; Tibricol; Zenusin

Dosage Forms
CAPSULE; TABLET; TABLET (EXTENDED-RELEASE)

Absorption
rapidly and fully absorbed

Interactions
Interactions for Nifedipine:

Beta-adrenergic Blocking Agents: Experience in over 1400 patients in a non-comparative clinical trial has shown that concomitant administration of nifedipine and beta-blocking agents is usually well tolerated, but there have been occasional literature reports suggesting that the combination may increase the likelihood of congestive heart failure, severe hypotension or exacerbation of angina.

Long Acting Nitrates: Nifedipine may be safely co-administered with nitrates, but there have been no controlled studies to evaluate the antianginal effectiveness of this combination.

Digitalis: Immediate Release Capsules: Since there have been isolated reports of patients with elevated digoxin levels, and there is a possible interaction between digoxin and nifedipine, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing nifedipine to avoid possible over- or under-digitalization. Extended Release Tablets: Administration of nifedipine with digoxin increased digoxin levels in 9 of 12 normal volunteers. The average increase was 45%. Another investigator found no increase in digoxin levels in 13 patients with coronary artery disease. In an uncontrolled study of over 200 patients with congestive heart failure during which digoxin blood levels were not measured, digitalis toxicity was not observed. Since there have been isolated reports of patients with elevated digoxin levels, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing nifedipine to avoid possible over- or under-digitalization.

Quinidine: Immediate Release Capsules: There have been rare reports of an interaction between quinidine and nifedipine (with a decreased plasma level of quinidine).

Coumarin Anticoagulants: There have been rare reports of increased prothrombin time in patients taking coumarin anticoagulants to whom nifedipine was administered. However, the relationship to nifedipine therapy is uncertain.

Cimetidine: A study in 6 healthy volunteers has shown a significant increase in peak nifedipine plasma levels (80%) and area-under-the-curve (74%) after a 1 week course of cimetidine at 1000 mg per day and nifedipine at 40 mg per day. Ranitidine produced smaller, non-significant increases. The effect may be mediated by the known inhibition of cimetidine on hepatic cytochrome P-450, the enzyme system probably responsible for the first-pass metabolism of nifedipine. If nifedipine therapy is initiated in a patient currently receiving cimetidine, cautious titration is advised.



Chemical IUPAC Name
dimethyl2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Formula
C17H18N2O6

Half Life
2 hours

Drug Type
Approved Drug

# Accession No
APRD00590

CAS Registry Number
21829-25-4

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