Acyclovir: profile and news
Deconstructing Myogen's market cap 07 Mar 2006
They found it superior to PAH market-leader Actelion's Tracleer (bosentan), which generated revenue for Actelion of $350 million in the first nine months of ... - Nature.com (subscription),
Pfizer launches Revatio in UK for lung disease 07 Mar 2006
Switzerland's Actelion currently makes the leading product for the condition, but its Tracleer medicine faces growing competition from Revatio and other rivals ... - Reuters.uk,
Actelion dips as Glaxo bolsters rival drug 07 Mar 2006
...will be the third drug to market to treat pulmonary arterial hypertension, a rare form of lung disease whose treatment is dominated by Actelion's Tracleer. ... - Reuters
FDA MedWatch - Tracleer (Bosentan): Recommended Dosage Adjustment ... Mar 2, 2006
BETHESDA, MD -- March 2, 2006 -- Actelion and FDA notified healthcare professionals of changes to the Tracleer (bosentan) prescribing information based on ... - DG News
Actelion 2005 profit rises 44 pct, Tracleer shines Feb 22, 2006
...rose 44 percent to 125.5 million Swiss francs ($95.87 million) in 2005, at the lower end of market expectations, as sales of its key Tracleer drug continued to ... - Reuters
UPDATE 2-Actelion 2005 profit rises 44 pct, Tracleer shines Feb 22, 2006
Actelion (ATLN.S: Quote, Profile, Research) rose 44 percent in 2005, at the lower end of market expectations, as sales of its key Tracleer drug continued to ... - Reuters
FDA and Actelion Pharmaceuticals Issue ‘Reminder’ of ... Mar 3, 2006
The notification underscored the need to continue monthly liver function monitoring for the duration of Tracleer treatment and the need to adhere to the ... - Newsinferno.com,
UPDATE 1-New liver damage info added to Actelion drug label Mar 2, 2006
2 (Reuters) - New information about rare cases of liver damage has been added to the label of Actelion's (ATLN.S: Quote, Profile, Research) Tracleer lung drug ... - Reuters
Actelion "Dear Doctor" Letter No Problem -GS Mar 3, 2006
1118 GMT [Dow Jones] Actelion's (ATLN.EB) "dear doctor" letter highlighting the case of a severe liver failure probably related to its drug Tracleer isn't an ... - New Ratings
(PZ) Actelion Announces Full Year 2005 Financial Results Feb 22, 2006
Executive Officer commented: "In 2005, our educational efforts resulted in a rapidly expanding PAH market, with consequently outstanding Tracleer(r) sales ... - Houston Chronicle,
Swiss pharma Actelion's profit rises 5%, sales gain 44% Feb 23, 2006
...based in Allschwil, Switzerland, said sales rose to CHF186.5 million from CHF130 million the previous year, driven by demand for its flagship drug Tracleer. ... - MarketWatch
JP Morgan Starts Actelion At Overweight Feb 28, 2006
...consider the company to be truly innovative, meaning it would be valued at biotech multiples, or whether they think its core product, Tracleer, was just a ... - New Ratings
Actelion Rebounds From Thu 'Over-Reaction' Mar 3, 2006
0857 GMT [Dow Jones]--Actelion (ATLN.EB) +5.1% at CHF113.6, grabbing back ground lost Thursday after updating Tracleer label. Market ... - New Ratings
UPDATE 3-Actelion 05 profit rises, outlook disappoints Feb 23, 2006
Actelion, which generates the lion's share of its revenues from sales of Tracleer, a drug that treats pulmonary arterial hypertension (PAH), said total ... - Reuters
European Technology Stocks Fall; ASML Slides, Vodafone Advances Mar 3, 2006
Actelion Ltd., a Swiss biotechnology company, increased 4.5 percent to 113 Swiss francs on optimism that sales of the company's Tracleer medicine won't be hurt ... - Bloomberg
European Stocks Climb; Adecco, BP, Publicis Shares Pace Gains Mar 3, 2006
...company, climbed 5.8 percent to 114.4 Swiss francs, the biggest gain in the Stoxx 600, on optimism that sales of the company's Tracleer medicine won't be hurt ... - Bloomberg
Actelion FY sales beat consensus but earnings miss Feb 22, 2006
Sales of the Swiss company's biggest product, pulmonary arterial hypertension drug Tracleer, were better than expected, up 41 pct to 633.2 mln sfr against ... - Forbes
Credit Suisse Cuts Actelion Target To CHF140 Feb 24, 2006
Higher spending is a sign the company will further leverage its flagship drug Tracleer's considerable leading position, with the rival drug Thelin from ... - New Ratings
WestLB Lifts Actelion's Target Feb 24, 2006
Adds the analyst conference confirmed views that Tracleer will continue to perform well in '06, sees more than CHF1B in group sales by '09, despite increasing ... - New Ratings
Lehman Lifts Actelion Target To CHF142 Feb 24, 2006
1628 GMT [Dow Jones]--Lehman Brothers lifts Actelion target to CHF142 from CHF135 after raising estimates for sales of company's main drug, Tracleer, in wake ... - New Ratings
Actelion Top-Line Growth Surprises Feb 23, 2006
0749 GMT [Dow Jones] Actelion's (ATLN.EB) full year '05 sales surprise with better-than-expected growth, especially for its flagship drug Tracleer, says analyst ... - New Ratings
Actelion Shr Price Reaction Overdone -ZKB Mar 2, 2006
ATLN.EB) share price reaction, closing -5.4% at CHF108.10, was overdone after US FDA asked for a labeling change of its flagship drug Tracleer to include info ... - New Ratings
WestLB Cuts Actelion To Hold Vs Buy >ATLN.EB Feb 23, 2006
In addition, WestLB argues that newsflow on potential competition for Actelion's flagship drug, Tracleer, is becoming more-and-more visible, in turn pressuring ... - New Ratings
Stakeholder Perspectives: Pulmonary Arterial Hypertension - A ... Jan 31, 2006
Actelion's Tracleer, the first oral therapy approved by the FDA in 2001, will come under significant competitive pressure over the next three years. ... - Pharmaceutical Business Review
Stakeholder Perspectives: Pulmonary Arterial Hypertension - A ... Jan 31, 2006
Actelion's Tracleer, the first oral therapy approved by the FDA in 2001, will come under significant competitive pressure over the next three years. ... - Pharmaceutical Business Review
Bear Stearns Resumes Actelion At Peer Perform Jan 27, 2006
Earnings growth until '08 looks secure, says Bear Stearns, with Myogen's (MYOG) Ambrisentan looking a serious competitor to Actelion's Tracleer from then on. ... - New Ratings
Roche, Actelion To Benefit From Lupus Jan 12, 2006
For Actelion, increasing the penetration rate of Tracleer 1% "to mimic the impact a larger PAH patient population" would already increase the value of the ... - New Ratings
Other information
Indication
For the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox
Pharmacology
Acyclovir is a synthetic deoxyguanosine analog and it is the prototype antiviral agent that is activated by viral thymidine kinase. The selective activity of acyclovir is due to its affinity for the thymidine kinase enzyme encoded by HSV and VZV.
Mechanism Of Action
Viral (HSV-1, HSV-2 and VZV) thymidine kinase converts acyclovir to the acyclovir monophosphate, which is then converted to the diphosphate by cellular guanylate kinase, and finally to the triphosphate by phosphoglycerate kinase, phosphoenolpyruvate carboxykinase, and pyruvate kinase. Acyclovir triphosphate competitively inhibits viral DNA polymerase and competes with the natural deoxyguanosine triphosphate, for incorporation into viral DNA. Once incorporated, acyclovir triphosphate inhibits DNA synthesis by acting as a chain terminator.
Drug Category
Antivirals; Nucleosides and Nucleotides (08:18.32); ATC:J05AB
Brand Names/Synonyms
AC2; Aciclovier; Aciclovir; Acycloguanosine; Acyclovir; Acyclovir Sodium; Alti-Acyclovir; Avirax; BW-248U; Valtrex; Vipral; Virorax; Wellcome-248u; Zovirax; Zovirax Wellstat Pac; Zovirax Zostab Pac
Dosage Forms
Intravenous Infusion; Capsules; Tablets; Suspension; Topical Cream; Topical Ointment
Absorption
Oral _ Bioavailability 10 to 20%
Interactions
Co-administration of probenecid with acyclovir has been shown to increase the mean half-life and the
area under the concentration-time curve. Urinary excretion and renal clearance were correspondingly reduced.
The clinical effects of this combination have not been studied.
Chemical IUPAC Name
2-amino-9-(2-hydroxyethoxymethyl)-3H-purin-6-one
Chemical Formula
C8H11N5O3
Half Life
2.5-3.3 hours
Drug Type
Approved Drug
# Accession No
APRD00567
CAS Registry Number
59277-89-3