Actos: profile and news






Local Schools Battle Prescription Pill Abuse  Mar 2, 2006
Now it's their medicine cabinets.". The drugs of choice? Percocet, Lortab and Xanax -- to name a few. "This is very strong stuff," says Officer Jamei Hamrick. ... - State Journal,

Hustonville woman charged with using teens to sell pills  Feb 24, 2006
According to police, the two high school students said that Stevenson supplied them with Lortab, Xanax and Valium to sell. During ... - Danville Advocate,

State medical board monitors Danville doctor  Feb 19, 2006
That lawsuit, which alleges Enlow caused or contributed to Wesley Ray's death by continuing to prescribe OxyContin and Lortab for him even though the doctor ... - Danville Advocate,

Man pleads guilty in drug ring case  Mar 4, 2006
15 indicted people, most of whom are members of the Westry family, sold drugs like crack cocaine, as well as OxyContin, Dilaudid, Lortab, methadone, morphine ... - Mobile Register,

Police Log for March 03, 2006  Mar 3, 2006
...the 300 block of Heltonville Road. 2:59 pm Theft of 14 Lortab pills from Hamilton Court Apartments. 12:53 am Officers assisted Dunn ... - Times-Mail (subscription),

Traffic stop yields pair of drug charges  Feb 21, 2006
...and after arresting Daniel for driving on a suspended license, the officer found a bag containing 25 rocks of crack cocaine, 10 doses of Lortab, a prescription ... - Athens Banner-Herald (subscription),

Woman with painted face and loud muffler robs drug store  Feb 22, 2006
The woman walked straight to the pharmacy counter in the rear of the store, produced a gun and demanded Lortab and OxyContin, a report said. ... - Kentucky.com,

A Day At The Doctor's Office  Feb 20, 2006
All medications are written by US Physicians and filled by US Pharmacies. Such medications as Hydrocodone, Vicodin, Lortab, Xanax are available. ... - DailyIndia.com,

Lawyers now leery of malpractice suits  Feb 4, 2006
Oxycontin. When Medicaid stopped covering that drug, Joey was switched to methadone, along with Soma and Lortab for breakthrough pain. ... - Gainesville Times,

Stonewall woman accused of providing drugs that led to man's death  Feb 24, 2006
...the additional counts, with most of those centering on allegations Hill improperly distributed controlled substances such as Lortab, methadone, oxycodone and ... - Shreveport Times,

Drug dealer sentenced in federal court  Mar 2, 2006
...seized approximately 112 grams of crystal methamphetamine, an estimated 40 grams of marijuana, and a large number of pills including Valium, Xanax and Lortab. ... - Kingsport Times News,

Woman accused of impersonating nurse practitioner to get ...  Feb 12, 2006
Police nabbed her as she was waiting for the prescription to be filled. Jones said Hosse was trying to get Lortab, a painkiller. ... - Poughkeepsie Journal,

Teen charged with rape  Feb 12, 2006
Whitaker was also found with several Lortab pills, needles, Brillo pads and crack pipes, according to his citation. Bond was set at 10 percent of $25,000. ... - Central Kentucky News Journal,

Doctor headed back to court over drugs  Feb 22, 2006
...program. He said he consumed painkiller Lortab between Dec. 28, 2004, and Jan. 1, 2005, without a valid prescription. On Jan. 24 ... - Shreveport Times,

Drug-addicted doctor sent back to prison for 2 years  Feb 23, 2006
Since he was released from prison in December 2003, Greer admitted consuming the painkiller Lortab between Dec. 28, 2004, and Jan. 1, 2005. ... - Shreveport Times,

Area News Briefs February 16, 2006: Daily Star publisher hit by ...  Feb 16, 2006
Joseph Cole, of 33 1/3 Fairview St., was charged with fourth-degree criminal sale of a controlled substance for allegedly selling about 20 Lortab tablets to ... - Oneonta Daily Star,

Painted lady robs Danville drug store for pills  Feb 21, 2006
She then produced a handgun and demanded Lortab and OxyContin, fleeing with an unknown number of the prescription pills in a red or maroon vehicle, possibly a ... - Danville Advocate,

Cases of TennCare Fraud leads to physicians’ arrest  Feb 21, 2006
February 12, 2003, a total of 565 days, Respondent [Ladd] prescribed for a patient approximately 1,235 Oxycontin, 120 Mscontin, 145 vicodin/lortab and 1,125 ... - Macon County Times,

Doctor denies drug, fraud allegations  Feb 24, 2006
Other charges accuse Hill of improperly distributed prescription drugs such as Lortab, methadone, oxycodone and Duragesic that were not for "legitimate medical ... - KTBS,

Knoxville woman charged with TennCare fraud  Feb 2, 2006
An indictment accuses Hill of knowingly trying to use her TennCare benefits to pay for a fraudulent prescription for the painkiller Lortab, a brand version of ... - WATE.com,

Members of prescription drug ring sentenced  Feb 2, 2006
Mr. Sullivan illegally sold Oxycontin, Lortab and other prescription medications over a four-year period in Greenville and Pickens counties, authorities said. ... - Anderson Independent Mail (subscription),

For the Record  Feb 12, 2006
...police spokeswoman Robin Snyder. She said officers seized crack, methamphetamine, marijuana and Lortab. Police on Thursday night ... - Salt Lake Tribune,

Jury urges 45 years in fatal wreck  Feb 16, 2006
Prosecutors said that Thomas C. Berryman, 37, was preoccupied with a package of Lortab prescription pain pills and driving at speeds of nearly 100 mph when he ... - Kentucky.com,

Murder trial set to begin  Feb 13, 2006
When Berryman was searched following his arrest at the Clark County Sheriff's Office, he allegedly had some Lortab pills in his pocket. ... - Winchester Sun,

For the Record  Feb 11, 2006
...police spokeswoman Robin Snyder. She said officers seized crack, methamphetamine, marijuana and Lortab.hill. Taylorsville police have ... - Salt Lake Tribune,

Wise County authorities rounding up drug suspects  Feb 8, 2006
Offenses range from distribution of cocaine and marijuana to distribution of prescription narcotics such as OxyContin, Ritalin and Lortab. ... - Kingsport Times News,

Two Hilton Head men arrested; cocaine, marijuana, pills found  Feb 16, 2006
Officers from the task force seized 25 grams of cocaine, 24 grams of marijuana, $283 in cash, Lortab prescription pain killers, scanners and two handguns from ... - Hilton Head Island Packet,

Prescription drug death toll rising, again  Feb 5, 2006
Xanax. The result may be a mix far more deadly than benzodiazepines combined with other drugs, such as OxyContin or Lortab. That's ... - Roanoke Times,

TFS mired in shakeup, controversy  Feb 10, 2006
31 with creating a hazardous condition in connection with a bag of marijuana and 10 Lortab pills found Jan. 26 in a vehicle on campus. ... - Northeast Georgian,

St Landry drug bust  Feb 14, 2006
A sheriff's spokesman says after getting permission to search Sellers' Mercedes, the deputy found about 10 thousand dollars worth of Lortab, Xanax, Valium and ... - KATC,

Lincoln Grand Jury indicts nine  Feb 5, 2006
She is accused of trying to pass a forged prescription for Lortab on Jan. 6 at Stanford Drug Store. Detective Allen was the grand jury witness. ... - Danville Advocate,

Across the area  Feb 10, 2006
...front window broken. Among the items taken were a bottle of generic Lortab and a bottle of Adderall, worth $356 total. Officials at ... - Augusta Chronicle (subscription),

News briefs: Feb. 3  Feb 2, 2006
Thursday. An indictment against Sharon Hill, 33, accuses her of knowingly trying to obtain the painkiller Lortab (hydrocodone). ... - Knoxville News Sentinel (subscription),

Knox woman arrested on scrip fraud  Feb 2, 2006
...today. An indictment against Sharon Hill, 33, accuses her of knowingly trying to obtain the painkiller Lortab (hydrocodone). The ... - Knoxville News Sentinel (subscription),


Other information


Indication
Treatment of Type II diabetes mellitus

Pharmacology
Pioglitazone, a member of the drug group known as the thiazolidinediones or "insulin sensitizers", is not chemically or functionally related to the alpha-glucosidase inhibitors, the biguanides, or the sulfonylureas. Pioglitazone targets insulin resistance and, hence, is used alone or in combination with insulin, metformin, or asulfonylurea as an antidiabetic agent.

Mechanism Of Action
Pioglitazone acts as an agonist at peroxisome proliferator activated receptors (PPAR) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPAR-gamma receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization. In this way, pioglitazone enhances tissue sensitivity to insulin.

Drug Category
Hypoglycemic Agents; Thazolidinediones; ATC:A10BG03

Brand Names/Synonyms
AD-4833; Actos; Actost; CHEMBANK3906; Pioglitazona [Inn-Spanish]; Pioglitazone; Pioglitazone Hydrochloride; Pioglitazone [Ban:Inn]; Pioglitazonum [Inn-Latin]

Dosage Forms
Oral tablets

Absorption
Following oral administration, in the fasting state, pioglitazone is first measurable in serum within 30 minutes, with peak concentrations observed within 2 hours. Food slightly delays the time to peak serum concentration to 3 to 4 hours, but does not alter the extent of absorption.

Interactions
-->Interactions for Pioglitazone:

In vivo drug-drug interaction studies have suggested that pioglitazone may be a weak inducer of CYP 450 isoform 3A4 substrate.



Chemical IUPAC Name
5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]thiazolidine-2,4-dione

Chemical Formula
C19H20N2O3S

Half Life
3-7 hours

Drug Type
Approved Drug

# Accession No
APRD00653

CAS Registry Number
111025-46-8

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