ADRIAMYCIN_PFS: profile and news

Other information

Indication
For the Treatment of Koposi's sarcome connected to AIDS

Pharmacology
Doxorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Doxorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Doxorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.

Mechanism Of Action
Doxorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Doxorubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.

Drug Category
Antibiotics; Antineoplastic Agents; ATC:L01DB01

Brand Names/Synonyms
ADM; Adriablastin; Adriamycin; Adriamycin Pfs; Adriamycin Rdf; Adriamycin Semiquinone; Adriblastin; Adriblastina; CCRIS 739; Caelyx;; DM2; Doxil; Doxo; Doxorubicin; Doxorubicin Hcl; Doxorubicin Hydrochloride; Doxorubicin [Usan:Ban:Inn]; Doxorubicina [Inn-Spanish]; Doxorubicine [Inn-French]; Doxorubicinum [Inn-Latin]; FI 106; FI-106; HSDB 3070; Rdf Rubex; Rubex

Dosage Forms
POWDER FOR SOLUTION

Absorption
Not Available

Interactions
-->Interactions for Doxorubicin:

No formal drug interaction studies have been conducted with DOXIL^® . Until specific compatibility data are available, it is not recommended that DOXIL^® be mixed with other drugs. DOXIL^® may interact with drugs known to interact with the conventional formulation of doxorubicin HCl.

Chemical IUPAC Name
10-(4-amino-5-hydroxy-6-methyl-oxan-2-yl)oxy-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione

Chemical Formula
C27H29NO11

Half Life
55 hours

Drug Type
Approved Drug

# Accession No
APRD00185

CAS Registry Number
23214-92-8